Skip to main content
SpringerLink
Log in

Will We Be Able to Desensitize Food Allergies by Either Injection or Oral Immunotherapy?

  • Invited Commentary
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2010;125:S116–S125.

    Article  PubMed  Google Scholar 

  2. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638–46.

    Article  PubMed  Google Scholar 

  3. Macdougall CF, Cant AJ, Colver AF. How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child. 2002;86:236–239.

    Article  CAS  Google Scholar 

  4. Savage JH, Matsui EC, Skripak JM, Wood RA. The natural history of egg allergy. J Allergy Clin Immunol. 2007;120:1413–7.

    Article  PubMed  CAS  Google Scholar 

  5. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow’s milk allergy. J Allergy Clin Immunol. 2007;120:1172–1177.

    Article  PubMed  CAS  Google Scholar 

  6. Fleischer DM. The natural history of peanut and tree nut allergy. Curr Allergy Asthma Rep. 2007;7:175–81.

    Article  PubMed  CAS  Google Scholar 

  7. Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102:e6.

    Article  PubMed  CAS  Google Scholar 

  8. Freeman J. Rush inoculation, with a special reference to hay fever treatment. Lancet. 1930;1:744–747.

    Article  Google Scholar 

  9. Golden DB, Valentine MD, Kagey-Sobotka A, Lichtenstein LM. Regimens of Hymenoptera venom immunotherapy. Ann Intern Med. 1980;92:620–624.

    PubMed  CAS  Google Scholar 

  10. Hunt KJ, Valentine MD, Sobotka AK, Benton AW, Amodio FJ, Lichtenstein LM. A controlled trial of immunotherapy in insect hypersensitivity. N Engl J Med. 1978;299:157–161.

    Article  PubMed  CAS  Google Scholar 

  11. Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol. 1997;99:744–751.

    Article  PubMed  CAS  Google Scholar 

  12. Enrique E, Pineda F, Malek T, et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J Allergy Clin Immunol. 2005;116:1073–1079.

    Article  PubMed  CAS  Google Scholar 

  13. Mempel M, Rakoski J, Ring J, Ollert M. Severe anaphylaxis to kiwi fruit: immunologic changes related to successful sublingual allergen immunotherapy. J Allergy Clin Immunol. 2003;111:1406–1409.

    Article  PubMed  Google Scholar 

  14. Kerzl R, Simonowa A, Ring J, Ollert M, Mempel M. Life-threatening anaphylaxis to kiwi fruit: protective sublingual allergen immunotherapy effect persists even after discontinuation. J Allergy Clin Immunol. 2007;119:507–508.

    Article  PubMed  Google Scholar 

  15. Kim EH, Bird JA, Kulis M, et al. Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization. J Allergy Clin Immunol. 2011;127:640–646

    Google Scholar 

  16. Patriarca G, Nucera E, Roncallo C, et al. Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther. 2003;17:459–465.

    Article  PubMed  CAS  Google Scholar 

  17. Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG. A protocol for oral desensitization in children with IgE-mediated cow’s milk allergy. Allergy. 2004;59:980–987.

    Article  PubMed  CAS  Google Scholar 

  18. Buchanan A, Green TD, Jones SM, et al. Egg oral immunotherapy for egg-allergic children. J Allergy Clin Immunol. 2007;119:199–205.

    Article  PubMed  CAS  Google Scholar 

  19. Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow’s milk-induced reactions. J Allergy Clin Immunol. 2008;121:343–347.

    Article  PubMed  CAS  Google Scholar 

  20. Skripak JM, Nash SD, Rowley H, et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow’s milk allergy. J Allergy Clin Immunol. 2008;122:1154–1160.

    Article  PubMed  CAS  Google Scholar 

  21. Narisety SD, Skripak JM, Steele P, et al. Open-label maintenance after milk oral immunotherapy for IgE-mediated cow’s milk allergy. J Allergy Clin Immunol. 2009;124:610–612.

    Article  PubMed  CAS  Google Scholar 

  22. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203–1207.

    Article  PubMed  Google Scholar 

  23. Clark AT, Islam S, King Y, et al. Successful oral tolerance induction in severe peanut allergy. Allergy. 2009;64:1218–1220.

    Article  PubMed  CAS  Google Scholar 

  24. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol. 2009;124:292–300.

    Article  PubMed  CAS  Google Scholar 

  25. Hoffman AM, Scurlock AM, Jones SM, et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol. 2009;124:286–291.

    Article  Google Scholar 

  26. Varshney P, Steele PH, Vickery BP, et al. Adverse reactions during peanut oral immunotherapy home dosing. J Allergy Clin Immunol. 2009;124:1351–1352.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Dr. Firszt has served on boards for the American Board of Pediatrics and the American Board of Allergy and Immunology.

Dr. Burks has received grant support from the Food Allergy and Anaphylaxis Network, the National Institutes of Health, and the Wallace Research Foundation; has served on boards for the American Academy of Allergy Asthma and Immunology, Food Allergy and Anaphylaxis Network, US Food and Drug Administration, Journal of Allergy and Clinical Immunology, and National Institutes of Health HAI; and has received other support from the Food Allergy Research Project Fund, Food Allergy and Anaphylaxis Network, National Institutes of Health, and the Wallace Research Foundation.

Disclosure

Dr. Burks has served as a consultant for ActoGeniX NV, Dannon Co. Probiotics, Intelliject, McNeil Nutritionals, Novartis, Nutricia, Pfizer, and Schering-Plough Corp. and owns stock/stock options in Allertein Therapeutics and MastCell.

Dr. Firszt reported no potential conflicts of interest relevant to this article.

Author information

Authors and Affiliations

  1. Division of Pediatric Allergy and Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Rafael Firszt & A. Wesley Burks

Authors
  1. Rafael Firszt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Wesley Burks
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Wesley Burks.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Firszt, R., Burks, A.W. Will We Be Able to Desensitize Food Allergies by Either Injection or Oral Immunotherapy?. Curr Allergy Asthma Rep 11, 273–276 (2011). https://doi.org/10.1007/s11882-011-0191-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11882-011-0191-x

Keywords

Search

Navigation