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New targets for modifying mast cell activation in asthma

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Abstract

Mast cells play a central role in innate immunity and in orchestrating the asthmatic response. Current medication relies on β-agonists to relieve bronchoconstriction and steroids to reduce inflammation. However, recently drugs such as leukotriene-receptor antagonists and anti-immunoglobulin E have come on to the market. In this paper, a number of potential targets for modifying mast cell activation in asthma are reviewed. Some are already under study, including clinical trials (eg, tryptase inhibitors); others are more speculative (eg, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity). In each case, where data are available, the action of the agents on human lung mast cells is described.

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Authors and Affiliations

  1. Respiratory Research Group, School of Medicine and Dentistry, The Queen’s University of Belfast, Institute of Clinical Science, Grosvenor Road, BT12 6BJ, Belfast, UK

    Madeleine Ennis BSc, PhD

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  1. Madeleine Ennis BSc, PhD
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Correspondence to Madeleine Ennis BSc, PhD.

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Ennis, M. New targets for modifying mast cell activation in asthma. Curr Allergy Asthma Rep 6, 247–251 (2006). https://doi.org/10.1007/s11882-006-0042-3

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  • DOI: https://doi.org/10.1007/s11882-006-0042-3

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