Skip to main content

Advertisement

SpringerLink
Log in

Détermination de HER2 dans les adénocarcinomes pour établir le pronostic et prédire la réponse aux traitements

Impact of HER2 status to define prognosis and to predict treatment efficacy in adenocarcinomas

  • Mise au Point
  • Published:
Bio tribune magazine

Résumé

Les avancées enregis trées depuis la caractérisation des cibles jusqu’à l’utilisation des thérapies ciblées sont un modèle de développement de l’innovation en cancérologie. La surexpression de HER2 est considérée de façon très hétérogène selon le type de cancer au plan du pronostic et pour prédire la réponse à une thérapie ciblée. Dans le cancer du sein, la surexpression de HER2 a d’abord été considérée comme un facteur pronostique avant de révolutionner la stratégie thérapeutique de 20 % des patients. Dans les autres localisations, de nombreuses publications rappor tent un intérêt pronostique de HER2, avec cependant un impact moindre en termes de prédiction de réponse au trastuzumab que dans le cancer du sein.

Abstract

The significant advances registered from targets definition to the use of targeted therapies are a model of innovative development in Oncology. HER2 overexpression has first been reported as progno stic factor before its consideration as a main parameter to predict treatment efficacy. In breast cancer HER2 determination is considered as a revolution for therapeutic strategy of about 15 to 20% of the patients. On the other hand, while HER2 is considered as a prognostic factor for many other cancers, its ability to predict efficacy of trastuzumab is much lower than in breast cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Références

  1. Aigner A, Hsieh SS, Malerczyk C, Czubayko F (2000) Reversal of HER2 over-expression renders human ovarian cancer cells highly resistant to taxol. Toxicology; 144: 221–228

    Article  CAS  PubMed  Google Scholar 

  2. Bianco R, Shin I, Ritter CA, et al. (2003) Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine-kinase inhibitors. Oncogene; 22: 2812–2822

    Article  CAS  PubMed  Google Scholar 

  3. Bookman MA, Darcy KM, Clarke-Pearson D, et al. (2003) Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology Group. J Clin Oncol; 21: 283–290

    Article  CAS  PubMed  Google Scholar 

  4. Bunn PA Jr, Helfrich B, Soriano AF, et al. (2001) Expression of HER2/neu in human lung cancer cell lines by immunohistochemistry and fluorescence in situ hybridization and its relationship to in vitro cytotoxicity by trastuzumab and chemotherapeutic agents. Clin Cancer Res; 7: 3239–3250

    CAS  PubMed  Google Scholar 

  5. Carter P, Presta L, Gorman CM, et al. (1992) Humanization of an antip185HER2 antibody for human cancer therapy. Proc Natl Acad Sci U S A; 89: 4285–4289

    Article  CAS  PubMed  Google Scholar 

  6. Dahabreh IJ, Linardou H, Siannis F, et al. (2008) Trastuzumab in the adjuvant treatment of early-stage breast cancer: a systematic review and meta-analysis of randomized controlled trials. Oncologist; 13: 620–630

    Article  CAS  PubMed  Google Scholar 

  7. Dimova I, Zaharieva B, Raitcheva S, et al. (2006) Tissue microarray analysis of EGFR and erbB2 copy number changes in ovarian tumors. Int J Gynecol Cancer; 16: 145–151

    Article  CAS  PubMed  Google Scholar 

  8. Downward J, Yarden Y, Mayes E, et al. (1984) Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature; 307: 521–527

    Article  CAS  PubMed  Google Scholar 

  9. El-Sahwi K, Bellone S, Cocco E, et al. (2010) In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma. Br J Cancer; 102: 134–143

    Article  CAS  PubMed  Google Scholar 

  10. Fisher BJ, Perera FE, Cooke AL, et al. (1998) Long-term follow-up of axillary node-positive breast cancer patients receiving adjuvant tamoxifen alone: patterns of recurrence. Int J Radiat Oncol Biol Phys; 42:117–123

    CAS  PubMed  Google Scholar 

  11. Fleming GF, Sill MW, Darcy KM, et al. (2010) Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol; 116: 15–20

    Article  CAS  PubMed  Google Scholar 

  12. Gatzemeier U, Groth G, Butts C, et al. (2004) Randomized phase II trial of gemcitabine/cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol; 15: 3–4

    Article  Google Scholar 

  13. Gieseg MA, de Bock C, Ferguson LR et al. (2001) Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine-kinase inhibitor CI-1033. Anticancer Drugs; 12: 683–690

    Article  CAS  PubMed  Google Scholar 

  14. Goldhirsch A, Wood WC, Gelber RD, et al. (2007) Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer. Ann Oncol; 18: 1133–1144

    Article  CAS  PubMed  Google Scholar 

  15. Grabsch H, Sivakumar S, Gray S, et al. (2010) HER2 expression in gastric cancer: rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series. Cell Oncol; 32: 57–65

    PubMed  Google Scholar 

  16. Gravalos C, Jimeno A (2008) HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol; 19: 1523–1529

    Article  CAS  PubMed  Google Scholar 

  17. Gusterson BA, Gelber RD, Goldhirsch A, et al. (1992) Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. J Clin Oncol; 10: 1049–1056

    CAS  PubMed  Google Scholar 

  18. Han H, Landreneau RJ, Santucci TS, et al. (2002) Prognostic value of immunohistochemical expressions of p53, HER2/neu, and bcl-2 in stage I non-small-cell lung cancer. Hum Pathol; 33: 105–110

    Article  CAS  PubMed  Google Scholar 

  19. Hansel DE, Ashfaq R, Rahman A, et al. (2005) A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase II alpha and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening and treatment. Am J Clin Pathol; 123: 28–35

    Article  CAS  PubMed  Google Scholar 

  20. Hayashi M, Inokuchi M, Takagi Y, et al. (2008) High expression of HER3 is associated with a decreased survival in gastric cancer. Clin Cancer Res; 14: 7843–7849

    Article  CAS  PubMed  Google Scholar 

  21. Hortobagyi G (2005) Trastuzumab in the treatment of breast cancer. N Engl J Med; 353: 1734–1736

    Article  CAS  PubMed  Google Scholar 

  22. Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al. (2006) Trastuzumab in combination with docetaxel or vinorelbine as adjuvat treatment of breast cancer: the FinHer trial. N Engl J Med; 354: 809–820

    Article  CAS  PubMed  Google Scholar 

  23. Jørgensen JT (2010) Targeted HER2 treatment in advanced gastric cancer. Oncology; 78: 26–33

    Article  PubMed  Google Scholar 

  24. Junker K, Stachetzki U, Rademacher D, et al. (2005) HER2/neu expression and amplification in non-small cell lung cancer prior to and after neoadjuvant therapy. Lung Cancer; 48: 59–67

    Article  PubMed  Google Scholar 

  25. Konecny GE, Santos L, Winterhoff B, et al. (2009) HER2 gene amplification and EGFR expression in a large cohort of surgically staged patients with nonendometrioid (type II) endometrial cancer. Br J Cancer; 100: 89–95

    Article  CAS  PubMed  Google Scholar 

  26. Langer CJ, Stephenson P, Thor A, et al. (2004) Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? Focus on Eastern Cooperative Oncology Group study 2598. J Clin Oncol; 22: 1171–1173

    Article  Google Scholar 

  27. Larbouret C, Robert B, Teulon I, et al. (2007) Combined anti-EGFR and antiHER2 monoclonal antibodies: preclinical efficacy in the treatment of pancreatic cancer. Med Sci (Paris); 23: 800–803

    Google Scholar 

  28. Marty M, Cognetti F, Maraninchi D, et al. (2005) Efficacy and safety of trastuzumab combined with docetaxel in patients with HER2-positive metastatic breast cancer given as first-line treatment: results of a randomized phase II trial (M77001). J Clin Oncol; 23: 4265–4274

    Article  CAS  PubMed  Google Scholar 

  29. Matsui Y, Inomata M, Tojigamori M, et al. (2005) Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model. Int J Oncol; 27: 681–685

    CAS  PubMed  Google Scholar 

  30. Meert AP, Martin B, Paesmans M, et al. (2003) The role of HER2/neu expression on the survival of patients with lung cancer: A systematic review of the literature. Br J Cancer; 89: 959–965

    Article  CAS  PubMed  Google Scholar 

  31. Mehta K, Haffty BG (1996) Long-term outcome in patients with four or more positive lymph nodes treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys; 35: 679–685

    Article  CAS  PubMed  Google Scholar 

  32. Meza-Junco J, Au HJ, Sawyer MB (2009) Trastuzumab for gastric cancer. Expert Opin Biol Ther; 9: 1543–1551

    Article  CAS  PubMed  Google Scholar 

  33. Mulligan AM, Pinnaduwage D, Bull SB, et al. (2008) Prognostic effect of basal-like breast cancers is time dependent: evidence from tissue microarray studies on a lymph node-negative cohort. Clin Cancer Res; 14: 4168–4174

    Article  CAS  PubMed  Google Scholar 

  34. Namer M, Gligorov J, Luporsi E, et al. (2007) Recommandations pour la pratique clinique de Saint Paul de Vence. Oncologie; 9: 593–644

    Article  Google Scholar 

  35. Perou CM, Sorlie T, Eisen MB, et al. (2000) Molecular portraits of human breast tumours. Nature; 406: 747–752

    Article  CAS  PubMed  Google Scholar 

  36. Piccart-Gebhart M, Procter M, Leyland-Jones B, et al. (2005) Trastuzumab after adjuvant chemotherapy for HER2-positive breast cancer. N Engl J Med; 353: 1659–1672

    Article  CAS  PubMed  Google Scholar 

  37. Pils D, Pinter A, Reibenwein J, et al. (2007) In ovarian cancer the prognostic influence of HER2/neu is not dependent on the CXCR4/SDF-1 signalling pathway. Br J Cancer; 96: 485–491

    Article  CAS  PubMed  Google Scholar 

  38. Ravdin PM, Siminoff LA, Davis GJ, et al. (2001) Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. J Clin Oncol; 19: 980–991

    CAS  PubMed  Google Scholar 

  39. Romond EH, Perez EA, Bryant J, et al. (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2positive breast cancer. N Engl J Med; 353: 1673–1684

    Article  CAS  PubMed  Google Scholar 

  40. Santin AD, Bellone S, Roman JJ, et al. (2008) Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu. Int J Gynaecol Obstet.; 102(2): 128–131 [Epub 2008 Jun 16]

    Article  CAS  PubMed  Google Scholar 

  41. Schmoor C, Sauerbrei W, Bastert G, et al. (2001) Long-term prognosis of breast cancer patients with 10 or more positive lymph nodes treated with CMF. Eur J Cancer; 37: 1123–1131

    Article  CAS  PubMed  Google Scholar 

  42. Serrano-Olvera A, Duenas-Gonzalez A, Gallardo-Rincon D, et al. (2006) Prognostic, predictive and therapeutic implications of HER2 in invasive epithelial ovarian cancer. Cancer Treat Rev; 32: 180–190

    Article  CAS  PubMed  Google Scholar 

  43. Sharif S, Ramanathan RK, Potter D, et al. (2008) HER2 gene amplification and chromosome 17 copy number do not predict survival of patients with resected pancreatic adenocarcinoma. Dig Dis Sci; 53: 3026–3032

    Article  CAS  PubMed  Google Scholar 

  44. Slamon D (2005) Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study. Breast Cancer Res Treat; 91: 1 [abstract]

    Article  Google Scholar 

  45. Slamon DJ, Clark GM, Wong SG, et al. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER2/neu oncogene. Science; 235: 177–182

    Article  CAS  PubMed  Google Scholar 

  46. Slamon DJ, Leyland-Jones B, Shak S, et al. (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med; 344: 783–792

    Article  CAS  PubMed  Google Scholar 

  47. Soerjomataram I, Louwman MW, Ribot JG, et al. (2008) An overview of prognostic factors for long-term survivors of breast cancer. Breast Cancer Res Treat; 107: 309–330

    Article  CAS  PubMed  Google Scholar 

  48. Stoecklein NH, Luebke AM, Erbersdobler A, et al. (2004) Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma. J Clin Oncol; 22: 4737–4745

    Article  CAS  PubMed  Google Scholar 

  49. Tsai CM, Chang KT, Perng RP, et al. (1993) Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER2/neu gene expression but not with ras gene mutations. J Natl Cancer Inst; 85: 897–901

    Article  CAS  PubMed  Google Scholar 

  50. Tuefferd M, Couturier J, Penault-Llorca F, et al. (2007) HER2 status in ovarian carcinomas: a multicenter GINECO study of 320 patients. PLoS One 2: e1138

    Article  PubMed  Google Scholar 

  51. Verri E, Guglielmini P, Puntoni M, et al. (2005) HER2/neu oncoprotein overexpression in epithelial ovarian cancer: evaluation of its prevalence and prognostic significance. Clinical study. Oncology; 68: 154–161

    Article  CAS  PubMed  Google Scholar 

  52. Wainberg ZA, Anghel A, Desai AJ, et al. (2010) Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin Cancer Res; 16(5): 1509–1519

    Article  CAS  PubMed  Google Scholar 

  53. Wolff AC, Hammond ME, Schwartz JN, et al. (2007) American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol; 25: 118–145

    Article  CAS  PubMed  Google Scholar 

  54. Wright C, Nicholson S, Angus B, et al. (1992) Relationship between cerbB-2 protein product expression and response to endocrine therapy in advanced breast cancer. Br J Cancer; 65: 118–121

    CAS  PubMed  Google Scholar 

  55. Yu GZ, Chen Y, Wang JJ (2009) Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance. J Cancer Res Clin Oncol; 135: 1331–139

    Article  CAS  PubMed  Google Scholar 

  56. Zhang XL, Yang YS, Xu DP, et al. (2009) Comparative study on overexpression of HER2/neu and HER3 in gastric cancer. World J Surg; 33: 2112–2118

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service d’oncologie-radiothérapie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, F-94000, Créteil, France

    P. Maroun, J. Ohnona, C. Murariu & Y. Belkacémi

  2. Faculté de médecine de Créteil, université de Parix-XII, 8, avenue du Général-Sarrail, F-94010, Créteil cedex, France

    P. Maroun, J. Ohnona, C. Murariu & Y. Belkacémi

  3. ervice d’oncologie médicale, hôpital Tenon, AP-HP, Cancer-Est, université de Paris-VI, 4, rue de la Chine, F-75020, Paris, France

    J. Gligorov

Authors
  1. P. Maroun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Gligorov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Ohnona
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Murariu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y. Belkacémi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y. Belkacémi.

Additional information

Association de radiothérapie et d’oncologie de la Méditerranée (Arome; www.aromecancer.org)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maroun, P., Gligorov, J., Ohnona, J. et al. Détermination de HER2 dans les adénocarcinomes pour établir le pronostic et prédire la réponse aux traitements. Bio trib. mag. 36, 30–35 (2010). https://doi.org/10.1007/s11834-010-0027-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11834-010-0027-3

Mots clés

Keywords

Search

Navigation