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Modulating nitric oxide levels in dorsal root ganglion neurons of rat with low-level laser therapy

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Abstract

Nitric oxide (NO) and nitric oxide synthase (NOS) have an important role in pain signaling transmission in animal models. Low-level laser therapy (LLLT) is known to have an analgesic effect, but the mechanism is unclear. The aim of the study is to investigate the influence of LLLT on NO release and NOS synthesis in dorsal root ganglion (DRG) neurons, in order to find whether LLLI can ameliorate pain through modulating NO production at the cellular level. The results show that in stress conditions, the laser irradiation at 658 nm can modulate NO production in DRG neurons with soma diameter of about 20 μm in a short time after illumination, and affect NOS synthesis in a dose-dependent manner. It is demonstrated that LLLT might treat pain by altering NO release directly and indirectly in DRG neurons.

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References

  1. Wei Gong, Yimei Huang and Shusen Xie, Chinese Optics Letters 7, 512 (2009).

    Article  Google Scholar 

  2. Hui Ma, Ying-xin Li, Hong-li Chen, Mei-ling Kang, Cheng-Yi Liu and Rui Duan, International Journal of Photoenergy 2012, 838496 (2012).

    Google Scholar 

  3. W. J. Xuan, F. Vatansever, L. Y. Huang, Q. H. Wu, Y. Xuan, T. H. Dai, T. Ando, T. Xu, Y. Y. Huang and M. R. Hamblin, PLoS ONE 8, e53454 (2013).

    Article  ADS  Google Scholar 

  4. W. L. He, C. J. Li, Z. P. Liu, J. F. Sun, Z. A. Hu, X. Yin and S. J. Zou, Lasers in Medical Science 28, 1581 (2013).

    Article  Google Scholar 

  5. M. L. Maia, L. R. Bonjardim, Jde S. Quintans, M. A. Ribeiro, L. G. Maia and P. C. Conti, Journal of Applied Oral Science 20, 594 (2012).

    Article  Google Scholar 

  6. G. Jamtvedt, K. T. Dahm, A. Christie, R. H. Moe, E. Haavardsholm, I. Holm and K. B. Hagen, Physical Therapy 88, 123 (2008).

    Article  Google Scholar 

  7. A. C. Alves, P. T. de Carvalho, M. Parente, M. Xavier, L. Frigo, F. Aimbire, E. C. Leal Junior and R. Albertini, Lasers in Medical Science 28, 529 (2013).

    Article  Google Scholar 

  8. J. D. Kingsley, T. Demchak and R. Mathis, Frontiers in Physiology 5, 306 (2014).

    Article  Google Scholar 

  9. C. Kudoh, K. Inomata, K. Okajima, M. Motegi and T. Ohshiro, Laser Therapy 1, 3 (1988).

    Google Scholar 

  10. R. T. Chow, M. A. David and P. J. Armati, Journal of the Peripheral Nervous System 12, 28 (2007).

    Article  Google Scholar 

  11. A. Miclescu and T. Gordh, Acta Anaesthesiologica Scandinavica 53, 1107 (2009).

    Article  Google Scholar 

  12. Y. Iwakiri, A. Satoh, S. Chatterjee, D. K. Toomre, C. M. Chalouni, D. Fulton, R. J. Groszmann, V. H. Shah and W. C. Sessa, Proceedings of the National Academy of Sciences of the United States of America 103, 19777 (2006).

    Article  ADS  Google Scholar 

  13. K. J. Bradley and P. M. Headley, Nitric Oxide Synthase Inhibitors and the Role of Nitric Oxide in Nociception. C. Bountra, R. Munglani and W. K. Schmidt, eds. Pain: Current Understanding, Emerging Therapies and Novel Approaches to Drug Discovery, Informa Health Care Pub-lisher, London, 637 (2003).

    Google Scholar 

  14. M. Chacur, R. J. Matos, A. S. Alves, A. C. Rodrigues, V. Gutierrez, Y. Cury and L. R. Britto, Brazilian Journal of Medical and Biological Research 43, 367 (2010).

    Article  Google Scholar 

  15. T. Sugiyama, M. Shinoda, T. Watase, K. Honda, R. Ito, K. Kaji, K. Urata, J. Lee, K. Ohara, O. Takahashi, S. Echizenya and K. Iwata, Journal of Dental Research 92, 1113 (2013).

    Article  Google Scholar 

  16. J. Mrowiec, A. Sieron, A. Plech, G. Cieslar, T. Biniszkiewicz and R. Brus, Proc. SPIE 3198, 83 (1997).

    Article  ADS  Google Scholar 

  17. F. J. Cidral-Filho, L. Mazzardo-Martins, D. F. Martins and A. R. S. Santos, Lasers in Medical Science 29, 695 (2014).

    Article  Google Scholar 

  18. U. H. Mitchell and G. L. Mack, American Journal of Physical Medicine & Rehabilitation 92, 151 (2013).

    Article  Google Scholar 

  19. Y. Moriyama, J. Nguyen, M. Akens, E. H. Moriyama and L. Lilge, Lasers in Surgery and Medicine 41, 227 (2009).

    Article  Google Scholar 

  20. L. Q. Zheng, J. X. Chen, Y. M. Huang, Y. H. Wang, H. Q. Yang, Y. D. Zhang and S. S. Xie, Lasers in Medical Science 29, 1209 (2014).

    Article  Google Scholar 

  21. Y. M. Huang, Y. H. Wang, X. Q. Shen, Y. H. Wang, L. Q. Zheng, H. Li and S. S. Xie, Chinese Optics Letters 10, S11701 (2012).

    Article  Google Scholar 

  22. L. Q. Zheng, C. M. Qiu, Y. H. Wang, Y. X. Zeng, H. Q. Yang, Y. D. Zhang and S. S. Xie, Proc. SPIE 9268, 926801 (2014).

    Article  Google Scholar 

  23. H. Q. Yang, Y. H. Wang, J. X. Chen, X. G. Chen, Y. M. Huang, H. Li, S. S. Xie and L. Q. Zheng, International Journal of Photoenergy 2012, 290796 (2012).

    Google Scholar 

  24. R. Ankri, H. Friedman, N. Savion, S. Kotev-Emeth, H. Breitbart and R. Lubart, Lasers in Surgery and Medicine 42, 348 (2010).

    Article  Google Scholar 

  25. Gayle M. Passmore, Journal of Pharmacological and Toxicological Methods 51, 201 (2005).

    Article  Google Scholar 

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Authors and Affiliations

  1. Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou, 350007, China

    Li-qin Zheng  (郑莉琴), Yu-hua Wang  (王瑜华), Yi-peng He  (何逸鹏), Jie Zhou  (周杰), Hong-qin Yang  (杨洪钦) & Shu-sen Xie  (谢树森)

  2. Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China

    Li-qin Zheng  (郑莉琴) & Yan-ding Zhang  (张彦定)

Authors
  1. Li-qin Zheng  (郑莉琴)
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  2. Yu-hua Wang  (王瑜华)
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  3. Yi-peng He  (何逸鹏)
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  4. Jie Zhou  (周杰)
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  5. Hong-qin Yang  (杨洪钦)
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  6. Yan-ding Zhang  (张彦定)
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  7. Shu-sen Xie  (谢树森)
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Corresponding author

Correspondence to Yan-ding Zhang  (张彦定).

Additional information

This work has been supported by the National Key Basic Research Program of China (No.2015CB352006), the National Natural Science Foundation of China (No.61335011), the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT1115), the Fujian Province Educational Project B (No.JB14023), and the Program for Youth of the Fujian Provincial Health and Family Planning Commission (No.2014-1-2).

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Zheng, Lq., Wang, Yh., He, Yp. et al. Modulating nitric oxide levels in dorsal root ganglion neurons of rat with low-level laser therapy. Optoelectron. Lett. 11, 233–236 (2015). https://doi.org/10.1007/s11801-015-5032-z

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  • DOI: https://doi.org/10.1007/s11801-015-5032-z

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