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Registre observationnel de l’efficacité et de la tolérance de la capsaïcine 8 % (Qutenza®) dans les douleurs neuropathiques périphériques localisées pharmacorésistantes

Observational register of efficiency and tolerance of capsaicin 8% (Qutenza®) in refractory peripheral localized neuropathic pain

  • Article Original / Original Article
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Douleur et Analgésie

Résumé

Les douleurs neuropathiques localisées peuvent bénéficier d’un traitement par la capsaïcine 8 % après échec des thérapeutiques de première intention. L’objectif de l’étude était d’évaluer dans une population de patients pharmacorésistants, adressés sur 16 mois en CETD, l’efficacité du Qutenza®, sa tolérance, et d’identifier les facteurs prédictifs de réponse. Parmi les 61 patients analysés, 39 % étaient soulagés d’au moins 30 % à deux mois. Les signes cutanés observés ont toujours été transitoires. Le seul facteur prédictif négatif retrouvé était une allodynie sévère au froid.

Abstract

Localized neuropathic pain may benefit from treatment with capsaicin 8% after failure of first-line therapy. The objective of the study was to evaluate in a population of drug-resistant patients, treated in a pain center for 16 months, the efficiency of Qutenza®, its tolerability and to identify predictors of favorable outcome. Of the 61 patients analyzed, the 30% reponder rate at two months was 39%. Cutaneous signs observed were always transient. The only negative predictive factor we observed was a preexisting severe cold allodynia.

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Authors and Affiliations

  1. Centre d’évaluation et de traitement de la douleur du CHU de Saint-Étienne, F-42055, Saint-Étienne cedex 2, France

    V. Beauvieux, M. -L. Navez, B. Manissol, C. Miallon, B. Pandraux & C. Créac’h

  2. Université Jean-Monnet, F-42023, Saint-Étienne, France

    C. Créac’h

Authors
  1. V. Beauvieux
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  2. M. -L. Navez
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  3. B. Manissol
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  4. C. Miallon
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  5. B. Pandraux
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  6. C. Créac’h
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Correspondence to V. Beauvieux.

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Beauvieux, V., Navez, M.L., Manissol, B. et al. Registre observationnel de l’efficacité et de la tolérance de la capsaïcine 8 % (Qutenza®) dans les douleurs neuropathiques périphériques localisées pharmacorésistantes. Douleur analg 27, 110–117 (2014). https://doi.org/10.1007/s11724-014-0367-y

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  • DOI: https://doi.org/10.1007/s11724-014-0367-y

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