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Genetic Risk Score Does Not Predict the Outcome of Obesity Surgery

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Abstract

Background

We evaluated the benefit of using combined genetic risk score (GRS) of known single nucleotide polymorphisms (SNPs) for body mass index (BMI) and waist/hip ratio (WHR) in the prediction of weight loss and weight regain after obesity surgery.

Methods

A total of 163 consecutive morbidly obese individuals undergoing Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) in a single bariatric center in Finland were recruited. Fasting blood samples were drawn after 12 h of fasting before and 1 year after bariatric operation. Data for weight regain and medication were collected with a questionnaire after 3.1 ± 2.7 years (mean ± SD) follow-up. Nonalcoholic steatohepatitis (NASH) was diagnosed with liver histology. Twenty BMI- and 13 WHR-related SNPs were genotyped. Linear regression was used to identify factors predicting weight loss and weight regain.

Results

Lower baseline BMI predicted greater decline in BMI (p = 0.0005) and excess weight loss (EWL) (p = 0.009). In the multiple linear regression analysis age and BMI, explained the variance of EWL during the first year while GRS, sex, fasting plasma glucose, serum insulin and NASH diagnosis did not have any effect. None of the baseline clinical variables explained BMI regain. The combined GRS did not associate with weight or BMI at baseline, with 1-year changes or with weight regain between 1 year and an average of 3.1 years follow-up.

Conclusions

In our study, we found that the genotype risk score does not predict weight loss after obesity surgery while lower baseline BMI predicted the greater weight loss.

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Acknowledgments

We thank Päivi Turunen, Tiina Sistonen and Matti Laitinen for their careful work in patient recruitment and laboratory analyses.

Conflict of interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Surgery, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

    P. Käkelä, I. Ilves, S. Venesmaa, M. Pääkkönen & H. Paajanen

  2. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

    T. Jääskeläinen, H. Gylling, M. Uusitupa & J. Pihlajamäki

  3. Department of Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland

    J. Torpström & J. Pihlajamäki

  4. Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland

    H. Gylling

  5. Research Unit, Kuopio University Hospital, Kuopio, Finland

    M. Uusitupa

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  1. P. Käkelä
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  2. T. Jääskeläinen
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  3. J. Torpström
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  4. I. Ilves
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  7. H. Gylling
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  9. M. Uusitupa
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  10. J. Pihlajamäki
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Corresponding author

Correspondence to J. Pihlajamäki.

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Käkelä, P., Jääskeläinen, T., Torpström, J. et al. Genetic Risk Score Does Not Predict the Outcome of Obesity Surgery. OBES SURG 24, 128–133 (2014). https://doi.org/10.1007/s11695-013-1080-2

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