Skip to main content

Advertisement

Log in

Stemming the Alzheimer tsunami: introduction to the special issue on reserve and resilience in Alzheimer’s disease

  • SI: Resilience/Reserve in AD
  • Published:
Brain Imaging and Behavior Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Alzheimer’s Association. (2016). 2016 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia, 12(4), 459–509.

    Article  Google Scholar 

  • Arenaza-Urquijo, E. M., de Flores, R., Gonneaud, J., Wirth, M., Ourry, V., Callewaert, W., et al. (2016). Distinct effects of late adulthood cognitive and physical activities on gray matter volume. Brain Imaging and Behavior. doi:10.1007/s11682-016-9617-3.

    PubMed  Google Scholar 

  • Boller, B., Mellah, S., Ducharme-Laliberte, G., & Belleville, S. (2016). Relationships between years of education, regional grey matter volumes, and working memory-related brain activity in healthy older adults. Brain Imaging and Behavior. doi:10.1007/s11682-016-9621-7.

    PubMed  Google Scholar 

  • Braak, H., & Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica, 82, 239–259.

    Article  CAS  PubMed  Google Scholar 

  • Dubal, D. B., Zhu, L., Sanchez, P. E., Worden, X., Broestl, L., Johnson, E., et al. (2015). Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. Journal of Neuroscience, 35(6), 2358–2371.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Franzmeier, N., Caballero, M. A., Taylor, A. N., Simon-Vermot, L., Buerger, K., Ertl-Wagner, B., et al. (2016). Resting-state global functional connectivity as a biomarker of cognitive reserve in mild cognitive impairment. Brain Imaging and Behavior. doi:10.1007/s11682-016-9599-1.

    PubMed  Google Scholar 

  • Gamazon, E. R., Wheeler, H. E., Shah, K. P., Mozaffari, S. V., Aquino-Michaels, K., Carroll, R. J., et al. (2015). A gene-based association method for mapping traits using reference transcriptome data. Nature Genetics, 47(9), 1091–1098. doi:10.1038/ng.3367.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hohman, T. J., Dumitrescu, L., Cox, N. J., Jefferson, A. L., & Alzheimer’s Neuroimaging, I. (2016). Genetic resilience to amyloid related cognitive decline. Brain Imaging and Behavior. doi:10.1007/s11682-016-9615-5.

    Google Scholar 

  • Kramer, A. F., Bherer, L., Colcombe, S. J., Dong, W., & Greenough, W. T. (2004). Environmental influences on cognitive and brain plasticity during aging. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 59(9), M940–M957.

    Article  Google Scholar 

  • Lambert, J. C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013). Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nature Genetics, 45(12), 1452–1458. doi:10.1038/ng.2802.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Okonkwo, O. C. (2014). At the crossroads of preclinical AD and normal brain ageing. Lancet Neurology, 13(10), 965–966. doi:10.1016/S1474-4422(14)70207-8.

    Article  PubMed  Google Scholar 

  • Okonkwo, O. C., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D., Cook, D., et al. (2014). Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology, 83(19), 1753–1760. doi:10.1212/WNL.0000000000000964.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pettigrew, C., Soldan, A., Zhu, Y., Wang, M. C., Brown, T., Miller, M., et al. (2016). Cognitive reserve and cortical thickness in preclinical Alzheimer’s disease. Brain Imaging and Behavior. doi:10.1007/s11682-016-9581-y.

    PubMed  Google Scholar 

  • Rentz, D. M., Mormino, E. C., Papp, K. V., Betensky, R. A., Sperling, R. A., & Johnson, K. A. (2016). Cognitive resilience in clinical and preclinical Alzheimer’s disease: the Association of Amyloid and Tau Burden on cognitive performance. Brain Imaging and Behavior. doi:10.1007/s11682-016-9640-4.

    PubMed  Google Scholar 

  • Selkoe, D. J. (2013). The therapeutics of Alzheimer’s disease: where we stand and where we are heading. Annals of Neurology, 74(3), 328–336. doi:10.1002/Ana.24001.

    Article  CAS  PubMed  Google Scholar 

  • Stern, Y. (2012). Cognitive reserve in ageing and Alzheimer’s disease. Lancet Neurology, 11(11), 1006–1012. doi:10.1016/S1474-4422(12)70191-6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stern, Y. (2016). An approach to studying the neural correlates of reserve. Brain Imaging and Behavior. doi:10.1007/s11682-016-9566-x.

    Google Scholar 

  • Suo, C., Gates, N., Fiatarone Singh, M., Saigal, N., Wilson, G. C., Meiklejohn, J., et al. (2016). Midlife managerial experience is linked to late life hippocampal morphology and function. Brain Imaging and Behavior. doi:10.1007/s11682-016-9649-8.

    PubMed  Google Scholar 

  • Vaque-Alcazar, L., Sala-Llonch, R., Valls-Pedret, C., Vidal-Pineiro, D., Fernandez-Cabello, S., Bargallo, N., et al. (2016). Differential age-related gray and white matter impact mediates educational influence on elders’ cognition. Brain Imaging and Behavior. doi:10.1007/s11682-016-9584-8.

    PubMed  Google Scholar 

  • Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Machulda, M., Lowe, V. J., et al. (2016). Effect of intellectual enrichment on AD biomarker trajectories: longitudinal imaging study. Neurology, 86(12), 1128–1135. doi:10.1212/WNL.0000000000002490.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yokoyama, J. S., Marx, G., Brown, J. A., Bonham, L. W., Wang, D., Coppola, G., et al. (2016). Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. Brain Imaging and Behavior. doi:10.1007/s11682-016-9598-2.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Ozioma C. Okonkwo or Prashanthi Vemuri.

Ethics declarations

Funding

This work was supported by National Institutes of Health grants K23 AG045957 (OCO), R21 AG051858 (OCO), R00 AG37573 (PV), R01 NS097495 (PV), and P50 AG016574/P1 (PV).

Conflict of interest

The authors report no conflicts of interest.

Additional information

Ozioma Okonkwo & Prashanthi Vemuri are Guest Editors for the Special Issue on Reserve and Resilience in Alzheimer’s disease.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Okonkwo, O.C., Vemuri, P. Stemming the Alzheimer tsunami: introduction to the special issue on reserve and resilience in Alzheimer’s disease. Brain Imaging and Behavior 11, 301–303 (2017). https://doi.org/10.1007/s11682-017-9677-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11682-017-9677-z

Keywords

Navigation