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Modification of EEG functional connectivity and EEG power spectra in overweight and obese patients with food addiction: An eLORETA study

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Abstract

We evaluated the modifications of electroencephalographic (EEG) power spectra and EEG connectivity in overweight and obese patients with elevated food addiction (FA) symptoms. Fourteen overweight and obese patients (3 men and 11 women) with three or more FA symptoms and fourteen overweight and obese patients (3 men and 11 women) with two or less FA symptoms were included in the study. EEG was recorded during three different conditions: 1) five minutes resting state (RS), 2) five minutes resting state after a single taste of a chocolate milkshake (ML-RS), and 3) five minutes resting state after a single taste of control neutral solution (N-RS). EEG analyses were conducted by means of the exact Low Resolution Electric Tomography software (eLORETA). Significant modification was observed only in the ML-RS condition. Compared to controls, patients with three or more FA symptoms showed an increase of delta power in the right middle frontal gyrus (Brodmann Area [BA] 8) and in the right precentral gyrus (BA 9), and theta power in the right insula (BA 13) and in the right inferior frontal gyrus (BA 47). Furthermore, compared to controls, patients with three or more FA symptoms showed an increase of functional connectivity in fronto-parietal areas in both the theta and alpha band. The increase of functional connectivity was also positively associated with the number of FA symptoms. Taken together, our results show that FA has similar neurophysiological correlates of other forms of substance-related and addictive disorders suggesting similar psychopathological mechanisms.

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Notes

  1. Due to the novelty of this study, a power analysis to determine the necessary number of subjects to include in our sample for detecting an effect of a given size was performed on the first ten patients recruited (five with three o more FA symptoms and five with two or less FA symptoms). The power analysis indicated that a sample of twenty-four patients (12 vs. 12) would have been necessary in order to have a satisfying statistical power (1 – beta = 0.80) given a probability level of 0.05.

  2. Five items of the original version (items #10, #11, #22, #24, and #25) with low item-total correlations, and three item (items #17, #18, and #23) not scored also in the original version of the scale were removed. A new item parcel was created from items #1 and #2, because they were almost perfectly correlated (r = 0.99).

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Acknowlegdments

Conflict of interest

Claudio Imperatori, Mariantonietta Fabbricatore, Marco Innamorati, Benedetto Farina, Maria Isabella Quintiliani, Dorian A. Lamis, Edoardo Mazzucchi, Anna Contardi, Catello Vollono, and Giacomo Della Marca declare that they have no conflicts of interest.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Human Sciences, European University of Rome, Via degli Aldobrandeschi 190, 00163, Rome, Italy

    Claudio Imperatori, Mariantonietta Fabbricatore, Marco Innamorati, Benedetto Farina, Maria Isabella Quintiliani & Anna Contardi

  2. Institute of Neurology, Catholic University, Rome, Italy

    Edoardo Mazzucchi, Catello Vollono & Giacomo Della Marca

  3. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA

    Dorian A. Lamis

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  1. Claudio Imperatori
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  2. Mariantonietta Fabbricatore
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  3. Marco Innamorati
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  10. Giacomo Della Marca
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Correspondence to Claudio Imperatori.

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Imperatori, C., Fabbricatore, M., Innamorati, M. et al. Modification of EEG functional connectivity and EEG power spectra in overweight and obese patients with food addiction: An eLORETA study. Brain Imaging and Behavior 9, 703–716 (2015). https://doi.org/10.1007/s11682-014-9324-x

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