Skip to main content
Log in

Electrical stimulation of auricular acupressure for dry eye: A randomized controlled-clinical trial

  • Original Article
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objective

To evaluate the clinical efficacy of electrical stimulation (ES) of auricular acupressure on reducing the ocular symptoms and signs before and after treatment for dry eye.

Methods

The inclusion criteria were the tear film break-up time (TFBUT) below 5 s and a Schirmer test-I below 5 mm in dry eyes with ocular symptoms for at least 6 months. Subjects were randomized into a treatment group (50 cases) with continuous low frequency ES under auricular acupressure at acupoints and a no ES under auricular acupressure (no-ES, control group, 50 cases) on the same acupoints. Auricular acupressure were stimulated with ES at 4 master points of both ears, which were performed twice a week for 4 weeks at each point for 30 s. The ocular symptoms, the TFBUT, and Schirmer test-I were evaluated before and after this procedure.

Results

There were significantly better scores in TFBUT (P=0.032), the Schirmer test-I (P=0.044) and ocular symptoms (P=0.029) at 3 months post-treatment in the treatment group than in the control group. The total effective rate in the treatment group was accomplished in 41 (82%) of the 50 cases of dry eye.

Conclusions

Auricular acupressure with ES at auricular acupoint improves ocular symptoms and signs of dry eye for a period of at least 3 months.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Kavoussi B, Ross BE. The neuroimmune basis of antiinflammatory acupuncture. Integr Cancer Ther 2007;6:251–257.

    Article  CAS  PubMed  Google Scholar 

  2. Uchida S, Hotta H. Acupuncture affects regional blood flow in various organs. Evid Based Complement Alternat Med 2008;5:145–151.

    Article  PubMed  Google Scholar 

  3. Gong L, Sun X. Treatment of intractable dry eyes: tear secretion increase and morphological changes of the lacrimal gland of rabbit after acupuncture. Acupunct Electrother Res 2007;32:223–233.

    Article  PubMed  Google Scholar 

  4. Greif R, Laciny S, Mokhtarani M, Doufas AG, Bakhshandeh M, Dorfer L, et al. Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement. Anesthesiology 2002;96:306–312.

    Article  PubMed  Google Scholar 

  5. Tolksdorf W, Ewen T, Kattermann R, Klose R, Lutz H. Electrostimulation anaesthesia and neurolept anaesthesia for cholecystectomy. A comparative study. Anaesthesist 1980;29:459–463.

    CAS  PubMed  Google Scholar 

  6. Fischer M, Just OH, Maric D. Electrostimulation anaesthesia for surgery of the limbs. Prakt Anaesth 1979;14:8–13.

    CAS  PubMed  Google Scholar 

  7. Han JS, Terenius L. Neurochemical basis of acupuncture analgesia. Annu Rev Pharmacol Toxicol 1982;22:193–220.

    Article  CAS  PubMed  Google Scholar 

  8. Tang NM, Dong HW, Wang XM, Tsui ZC, Han JS. Cholecystokinin antisense RNA increases the analgesic effect induced by electroacupuncture or low dose morphine: conversion of low responder rats into high responders. Pain 1997;71:71–80.

    Article  CAS  PubMed  Google Scholar 

  9. Dawidson I, Angmar-Månsson B, Blom M, Theodorsson E, Lundeberg T. Sensory stimulation (acupuncture) increases the release of vasoactive intestinal polypeptide in the saliva of xerostomia sufferers. Neuropeptides 1998;32:543–548

    Article  CAS  PubMed  Google Scholar 

  10. Mayer DJ. Biological mechanism of acupuncture. Prog Brain Res 2000;122:457–477.

    Article  CAS  PubMed  Google Scholar 

  11. Bai H, Yu P, Yu M. Effect of electroacupuncture on sex hormone levels in patients with Sjogren's syndrome. Acupunct Res (Chin) 2007;32:203–206.

    Google Scholar 

  12. The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007). Ocul Surf 2007;5:75–92.

  13. Liu XQ, Zhu HY, Ruan WJ. Clinical study on combined acupuncture and Chinese medicinal fumigation for dry eye syndrome. J Acupunct Tunia Sci 2013;11:79–83.

    Article  Google Scholar 

  14. Burstein NL. The effects of topical drugs and preservatives on the tears and corneal epithelium in dry eye. Trans Ophthalmol Soc U K 1985;104:402–409.

    PubMed  Google Scholar 

  15. Burstein NL. Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. Surv Ophthalmol 1980;25:15–30.

    Article  CAS  PubMed  Google Scholar 

  16. Diestelhorst M, Grunthal S, Suverkrup R. Dry drops: a new preservatives-free drug delivery system. Graefes Arch Clin Exp Ophthalmol 1990;237:394–398.

    Article  Google Scholar 

  17. Murube J, Murube E. Treatment of dry eye by blocking the lacrimal canaliculi. Surv Ophthalmol 1996;40:463–480.

    Article  CAS  PubMed  Google Scholar 

  18. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999;19:201–211.

    Article  CAS  PubMed  Google Scholar 

  19. Nelson JD, Friedlaender M, Yeatts RP, Yee R, McDermott M, Orlin S, et al. Oral pilocarpine for symptomatic relief of keratoconjunctivitis sicca in patients with Sjogren's syndrome. The MGI PHARMA Sjogren's Syndrome Study Group. Adv Exp Med Biol 1998;438:979–983.

    CAS  Google Scholar 

  20. Lee MS, Shin BC, Choi TY, Ernst E. Acupuncture for treating dry eye: a systemic review. Acta Ophthalmol 2011;89:101–106.

    Article  PubMed  Google Scholar 

  21. Wang ZL, He HQ, Huang D, Shi CG. Effect of integral syndrome differentiation acupuncture on the tear film stability in the patient of xerophthalmia. Chin Acupunct (Chin) 2005;25:460–463.

    CAS  Google Scholar 

  22. Stux G, Pomeranz B, eds. Basics of acupuncture. 4th ed. Berlin: Springer; 1998.

    Book  Google Scholar 

  23. Tseng KL, Liu HJ, Tso KY, Woung LC, Su YC, Lin JG. A clinical study of acupuncture and SSP (silver spike point) electro-therapy for dry eye syndrome. Am J Chin Med 2006;34:197–206.

    Article  PubMed  Google Scholar 

  24. Kim TH, Kang JW, Kim KH, Kang KW, Shin MS, Jung SY, et al. Acupuncture for the treatment of dry eye: a multicenter randomised controlled trial with active comparison intervention (artificial teardrops). PLoS One 2012;7:36638.

    Article  Google Scholar 

  25. Yang W, Zhang YC, Liu D, Sun H, Chen LQ. Clinical observation on the method for nourishing blood and moisturizing eye on xerophthalmia. Chin Acupunct (Chin) 2006;26:571–573.

    Google Scholar 

  26. Goertz CM, Niemtzow R, Burns SM, Fritts MJ, Crawford CC, Jonas WB. Auricular acupuncture in the treatment of acute pain syndromes: A pilot study. Mil Med 2006;171:1010–1014.

    Article  PubMed  Google Scholar 

  27. Shin MS, Kim JI, Lee MS, Kim KH, Choi JY, Kang KW, et al. Acupuncture for treating dry eye: a randomized placebocontrolled trial. Acta Ophthalmol 2010;88:328–333.

    Article  Google Scholar 

  28. Park JE, Lee MS, Choi JY, Kim BY, Choi SM. Adverse events associated with acupuncture: a prospective survey. J Altern Complement Med 2010;16:959–963.

    Article  PubMed  Google Scholar 

  29. Zhao L, Zhang FW, Li Y, Wu X, Zheng H, Cheng LH, et al. Adverse events associated with acupuncture: three multicentre randomized controlled trials of 1968 cases in China. Trials 2011;24;12–87.

    CAS  Google Scholar 

  30. Witt CM, Pach D, Reinhold T, Wruck K, Brinkhaus B, Mank S, et al. Treatment of the adverse effects from acupuncture and their economic impact: a prospective study in 73,406 patients with low back or neck pain. Eur J Pain 2011;15:193–197.

    Article  PubMed  Google Scholar 

  31. Lemp MA, Bron AJ, Baudouin C, Benítez Del, Castillo JM, Geffen D, et al. Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol 2011;151:792–798.

    Article  PubMed  Google Scholar 

  32. Riederer P, Tenk H, Werner H, Bischko J, Rett A, Krisper H. Manipulation of neurotransmitters by acupuncture (a preliminary communication). J Neural Transm 1975;37:81–94.

    Article  CAS  PubMed  Google Scholar 

  33. Reichmanis M, Marino AA, Becker RO. Electrical correlates of acupuncture points. IEEE Trans Biomed Eng 1975;22: 533–535.

    Article  CAS  PubMed  Google Scholar 

  34. Oke SL, Tracey KJ. The inflammatory reflex and the role of complementary and alternative medical therapies. Ann N Y Acad Sci 2009;1172:172–180.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Nepp J, Jandrasits K, Schauersberger J, Schild G, Wedrich A, Sabine GL, et al. Is acupuncture an useful tool for paintreatment in ophthalmology? Acupunct Electrother Res 2002;27:171–182.

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

The authors would like to thank Prof. Byung Mann Cho, Department of Preventive Medicine, Pusan National University School of Medicine for statistical analysis.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jong Soo Lee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, J.S., Hwang, S.H., Shin, B.C. et al. Electrical stimulation of auricular acupressure for dry eye: A randomized controlled-clinical trial. Chin. J. Integr. Med. 23, 822–828 (2017). https://doi.org/10.1007/s11655-016-2449-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-016-2449-6

Keywords

Navigation