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Effectiveness of Bufei Yishen Granule (补肺益肾颗粒) combined with acupoint sticking therapy on quality of life in patients with stable chronic obstructive pulmonary disease

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Abstract

Objective

To evaluate the efficacy of Bufei Yishen Granule (补肺益肾颗粒, BFYSG) combined with Shufei Tie (舒肺贴) acupoint sticking therapy on quality of life of patients with stable chronic obstructive pulmonary disease (COPD).

Methods

A multi-center, double-blinded, double-dummy and randomized controlled method was adopted in this trial. A total of 244 patients were randomly assigned to a trial group and a control group according to the random number, each with 122 patients; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent form. In the trial group, patients were treated with BFYSG combined with “Shufei Tie” acupoint sticking therapy and sustained-release theophylline dummy, and in the control group patients were treated with oral sustained-release theophylline and BFYSG dummy combined with “Shufei Tie” acupoint sticking therapy dummy. The therapeutic course for two groups was 4 months and the follow-up was 6 months. The frequency and duration of acute exacerbation calculated by adding up each frequency and duration of acute exacerbation in treatment and follow-up time respectively, the quality of life measured by the World Health Organization Quality of Life (WHOQOL)-BREF scale and adult COPD quality of life (COPD-QOL) scale were observed.

Results

Among the 244 enrolled patients, 234 were screened for full analysis set (FAS); 221 were screened for per-protocol analysis set (PPS). After 4-month treatment and 6-month follow-up there were differences between the trial group and the control group in frequency of acute exacerbation (FAS: P=0.013; PPS: P=0.046); duration of acute exacerbation (FAS: P=0.005; PPS: P=0.006); scores of physiological, psychological and environment aspects of the WHOQOL-BREF questionnaire (FAS: P=0.002, P=0.006, P=0.000; PPS: P=0.00, P=0.001, P=0.000); scores of daily living ability, social activity, depression symptoms aspects of the COPD-QOL questionnaire (FAS: P=0.000, P=0.000, P=0.006; PPS: P=0.002, P=0.001, P=0.001).

Conclusion

BFYSG combined with acupoint sticking therapy could improve the quality of life of patients with stable COPD.

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Authors and Affiliations

  1. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China

    Yang Xie  (谢 洋)

  2. The Geriatric Department, Henan University of Traditional Chinese Medicine, Zhengzhou, 450008, China

    Yang Xie  (谢 洋) & Jian-sheng Li  (李建生)

  3. Department of Respiratory, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China

    Xue-qing Yu  (余学庆) & Su-yun Li  (李素云)

  4. Department of Respiratory, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, Hefei, 230031, China

    Nian-zhi Zhang  (张念志) & Ze-geng Li  (李泽庚)

  5. Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450008, China

    Su-ju Shao  (邵素菊)

  6. Department of Respiratory, the Second People’s Hospital of Jiaozuo City, Jiaozuo, Henan, 454001, China

    Lian-xiang Guo  (郭莲香)

  7. Department of Respiratory, Kaifeng Hospital of Traditional Chinese Medicine, Kaifeng, Henan, 475001, China

    Lin Zhu  (朱 琳)

  8. Department of Respiratory, Huaihe Hospital of Henan University, Kaifeng, Henan, 475000, China

    Yi-jie Zhang  (张祎捷)

Authors
  1. Yang Xie  (谢 洋)
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  2. Jian-sheng Li  (李建生)
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  3. Xue-qing Yu  (余学庆)
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  5. Nian-zhi Zhang  (张念志)
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  6. Ze-geng Li  (李泽庚)
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  7. Su-ju Shao  (邵素菊)
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  8. Lian-xiang Guo  (郭莲香)
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  9. Lin Zhu  (朱 琳)
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  10. Yi-jie Zhang  (张祎捷)
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Corresponding author

Correspondence to Jian-sheng Li  (李建生).

Additional information

Supported by the Specific Research in Traditional Chinese Medicine Industry of State Administration of Traditional Chinese Medicine (No. 200707018)

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Xie, Y., Li, Js., Yu, Xq. et al. Effectiveness of Bufei Yishen Granule (补肺益肾颗粒) combined with acupoint sticking therapy on quality of life in patients with stable chronic obstructive pulmonary disease. Chin. J. Integr. Med. 19, 260–268 (2013). https://doi.org/10.1007/s11655-013-1438-2

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  • DOI: https://doi.org/10.1007/s11655-013-1438-2

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