Skip to main content

Advertisement

Log in

Evolution of Surgical Treatment for Rectal Cancer: a Review

  • Review Article
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Surgery that produces an optimal total mesorectal excision (TME) resection specimen remains the cornerstone of curative rectal cancer management. In the modern era, despite the results of recent randomised trials, laparoscopic TME is a crucial technique in the TME surgery armamentarium. Laparoscopic surgery offers the benefit of magnified views that aid sharp and precise dissection. However operating in the confines of a narrow pelvis, particularly when the mesorectum is bulky, requires significant technical skill. This is compounded by limited angulation of laparoscopic instruments and staplers. The final challenge is to preserve the integrity of the mesorectum during delivery of the specimen. The principles of TME surgery, on which Bill Heald founded the Basingstoke Colorectal unit, can equally be applied to laparoscopic, transanal and robotic TME, but great care must be taken to preserve the key principle—that no steps are taken that have the potential to shed tumour cells or compromise the quality of the mesorectal specimen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Mayo CH. Evolution in the treatment of cancer of the rectum. J Am Med Assoc. 1903;XL(17):1127–9.

    Article  Google Scholar 

  2. Monson JR, Weiser MR, Buie WD, Chang GJ, Rafferty JF, Buie WD, et al. Practice parameters for the management of rectal cancer (revised). Dis Colon Rectum. 2013;56(5):535–50.

    Article  CAS  PubMed  Google Scholar 

  3. Martling AL, Holm T, Rutqvist LE, Moran BJ, Heald RJ, Cedemark B. Effect of a surgical training programme on outcome of rectal cancer in the County of Stockholm. Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project. Lancet. 2000;356(9224):93–6.

    Article  CAS  PubMed  Google Scholar 

  4. Quirke P, Steele R, Monson J, Grieve R, Khanna S, Couture J, et al. Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet. 2009;373(9666):821–8.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Heald RJ. A new approach to rectal cancer. Br J Hosp Med. 1979;22(3):277–81.

    CAS  PubMed  Google Scholar 

  6. Heald R. Chapter 1: The evolution of a concept: the total mesorectal excision story. In: Moran B, Heald RJ, editors. Manual of total mesorectal excision: CRC Press; 2013. p. 1–30.

  7. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery—the clue to pelvic recurrence? Br J Surg. 1982;69(10):613–6.

    Article  CAS  PubMed  Google Scholar 

  8. Heald RJ. The ‘Holy Plane’ of rectal surgery. J R Soc Med. 1988;81(9):503–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;1(8496):1479–82.

    Article  CAS  PubMed  Google Scholar 

  10. MacFarlane JK, Ryall RD, Heald RJ. Mesorectal excision for rectal cancer. Lancet. 1993;341(8843):457–60.

    Article  CAS  PubMed  Google Scholar 

  11. Moran B. Chapter 7: total mesorectal excision for rectal cancer. In: Moran B, Heald RJ, editors. Manual of Total Mesorectal Excision: CRC Press; 2013. p. 103–23.

  12. Moran BJ. Stapling instruments for intestinal anastomosis in colorectal surgery. Br J Surg. 1996;83(7):902–9.

    Article  CAS  PubMed  Google Scholar 

  13. Vignali A, Fazio VW, Lavery IC, Milsom JW, Church JM, Hull TL, et al. Factors associated with the occurrence of leaks in stapled rectal anastomoses: a review of 1,014 patients. J Am Coll Surg. 1997;185(2):105–13.

    Article  CAS  PubMed  Google Scholar 

  14. Matthiessen P, Hallbook O, Rutegard J, Simert G, Sjodahl R. Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg. 2007;246(2):207–14.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Peeters KC, Tollenaar RA, Marijnen CA, Klein Kranenbarg E, Steup WH, Wiggers T, et al. Risk factors for anastomotic failure after total mesorectal excision of rectal cancer. Br J Surg. 2005;92(2):211–6.

    Article  CAS  PubMed  Google Scholar 

  16. McDermott FD, Heeney A, Kelly ME, Steele RJ, Carlson GL, Winter DC. Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg. 2015;102(5):462–79.

    Article  CAS  PubMed  Google Scholar 

  17. Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg. 1994;81(8):1224–6.

    Article  CAS  PubMed  Google Scholar 

  18. Battersby NJ HP, Moran B, Mercury II Study Group. A colo-anal anastomosis for an adenocarcinoma within 3 cm of the anal verge is associated with a high leak rate: experience from the MERCURY II low rectal cancer study. Abstract ESCP Meeting Belgrade. Colorectal Disease. 2013;15:13–26.

  19. F D McDermott SA, J Smith, R J C Steele, G L Carlson, D C Winter. Prevention, diagnosis and management of colorectal anastomotic leakage. Association of Surgeons of Great Britain and Ireland [Internet]. 2016 18/2/17. Available from: http://www.acpgbi.org.uk/search-results/?for=leak.

  20. Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, et al. Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery. 2010;147(3):339–51.

    Article  PubMed  Google Scholar 

  21. Bretagnol F, Panis Y, Rullier E, Rouanet P, Berdah S, Dousset B, et al. Rectal cancer surgery with or without bowel preparation: the French GRECCAR III multicenter single-blinded randomized trial. Ann Surg. 2010;252(5):863–8.

    Article  PubMed  Google Scholar 

  22. Veenhof AA, van der Peet DL, Meijerink WJ, Cuesta MA. Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg. 2008;247(4):718–9; author reply 9-20.

    Article  PubMed  Google Scholar 

  23. Cecil TD, Taffinder N, Gudgeon AM. A personal view on laparoscopic rectal cancer surgery. Colorectal Dis. 2006;8 Suppl 3:30–2.

    Article  PubMed  Google Scholar 

  24. Bagshaw PF, Allardyce RA, Frampton CM, Frizelle FA, Hewett PJ, McMurrick PJ, et al. Long-term outcomes of the australasian randomized clinical trial comparing laparoscopic and conventional open surgical treatments for colon cancer: the Australasian Laparoscopic Colon Cancer Study trial. Ann Surg. 2012;256(6):915–9.

    Article  PubMed  Google Scholar 

  25. Fleshman J, Sargent DJ, Green E, Anvari M, Stryker SJ, Beart RW, Jr., et al. Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial. Ann Surg. 2007;246(4):655–62; discussion 62-4.

    Article  PubMed  Google Scholar 

  26. Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365(9472):1718–26.

    Article  PubMed  Google Scholar 

  27. Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, et al. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol. 2005;6(7):477–84.

    Article  PubMed  Google Scholar 

  28. Stevenson AR, Solomon MJ, Lumley JW, Hewett P, Clouston AD, Gebski VJ, et al. Effect of laparoscopic-assisted resection vs open resection on pathological outcomes in rectal cancer: the ALaCaRT randomized clinical trial. JAMA. 2015;314(13):1356–63.

    Article  CAS  PubMed  Google Scholar 

  29. Fleshman J, Branda M, Sargent DJ, Boller AM, George V, Abbas M, et al. Effect of laparoscopic-assisted resection vs open resection of stage II or III rectal cancer on pathologic outcomes: the ACOSOG Z6051 randomized clinical trial. Jama. 2015;314(13):1346–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Green BL, Marshall HC, Collinson F, Quirke P, Guillou P, Jayne DG, et al. Long-term follow-up of the Medical Research Council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer. Br J Surg. 2013;100(1):75–82.

    Article  CAS  PubMed  Google Scholar 

  31. Bonjer HJ, Deijen CL, Abis GA, Cuesta MA, van der Pas MH, de Lange-de Klerk ES, et al. A randomized trial of laparoscopic versus open surgery for rectal cancer. N Engl J Med. 2015;372(14):1324–32.

    Article  CAS  PubMed  Google Scholar 

  32. Kang SB, Park JW, Jeong SY, Nam BH, Choi HS, Kim DW, et al. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol. 2010;11(7):637–45.

    Article  PubMed  Google Scholar 

  33. Jeong SY, Park JW, Nam BH, Kim S, Kang SB, Lim SB, et al. Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial. Lancet Oncol. 2014;15(7):767–74.

    Article  PubMed  Google Scholar 

  34. Arezzo A, Passera R, Salvai A, Arolfo S, Allaix ME, Schwarzer G, et al. Laparoscopy for rectal cancer is oncologically adequate: a systematic review and meta-analysis of the literature. Surg Endosc. 2015;29(2):334–48.

    Article  PubMed  Google Scholar 

  35. Qu H, Liu Y, Bi DS. Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: a systematic review and meta-analysis. Surg Endosc. 2015;29(12):3608–17.

    Article  PubMed  Google Scholar 

  36. Lu ZR, Rajendran N, Lynch AC, Heriot AG, Warrier SK. Anastomotic leaks after restorative resections for rectal cancer compromise cancer outcomes and survival. Dis Colon Rectum. 2016;59(3):236–44.

    Article  PubMed  Google Scholar 

  37. Mirnezami A, Mirnezami R, Chandrakumaran K, Sasapu K, Sagar P, Finan P. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg. 2011;253(5):890–9.

    Article  PubMed  Google Scholar 

  38. Moran BJ, Docherty A, Finnis D. Novel stapling technique to facilitate low anterior resection for rectal cancer. Br J Surg. 1994;81(8):1230.

    Article  CAS  PubMed  Google Scholar 

  39. Zhou C, Ren Y, Li J, Li X, He J, Liu P. Systematic review and meta-analysis of rectal washout on risk of local recurrence for cancer. J Surg Res. 2014;189(1):7–16.

    Article  PubMed  Google Scholar 

  40. Colombo PE, Bertrand MM, Alline M, Boulay E, Mourregot A, Carrere S, et al. Robotic versus laparoscopic total mesorectal excision (TME) for sphincter-saving surgery: is there any difference in the transanal TME rectal approach?: a single-center series of 120 consecutive patients. Ann Surg Oncol. 2016;23(5):1594–600.

    Article  PubMed  Google Scholar 

  41. Ahmed J, Kuzu MA, Figueiredo N, Khan J, Parvaiz A. Three-step standardized approach for complete mobilization of the splenic flexure during robotic rectal cancer surgery. Colorectal Dis. 2016;18(5):O171–4.

    Article  CAS  PubMed  Google Scholar 

  42. Speicher PJ, Englum BR, Ganapathi AM, Nussbaum DP, Mantyh CR, Migaly J. Robotic low anterior resection for rectal cancer: a national perspective on short-term oncologic outcomes. Ann Surg. 2015;262(6):1040–5.

    Article  PubMed  Google Scholar 

  43. Lin S, Jiang HG, Chen ZH, Zhou SY, Liu XS, Yu JR. Meta-analysis of robotic and laparoscopic surgery for treatment of rectal cancer. World J Gastroenterol. 2011;17(47):5214–20.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Memon S, Heriot AG, Murphy DG, Bressel M, Lynch AC. Robotic versus laparoscopic proctectomy for rectal cancer: a meta-analysis. Ann Surg Oncol. 2012;19(7):2095–101.

    Article  PubMed  Google Scholar 

  45. Xiong B, Ma L, Zhang C, Cheng Y. Robotic versus laparoscopic total mesorectal excision for rectal cancer: a meta-analysis. J Surg Res. 2014;188(2):404–14.

    Article  PubMed  Google Scholar 

  46. Poon JT, Law WL. Laparoscopic resection for rectal cancer: a review. Ann Surg Oncol. 2009;16(11):3038–47.

    Article  PubMed  Google Scholar 

  47. Biffi R, Luca F, Bianchi PP, Cenciarelli S, Petz W, Monsellato I, et al. Dealing with robot-assisted surgery for rectal cancer: current status and perspectives. World J Gastroenterol. 2016;22(2):546–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Jayne DG. ACPGBI plenary research session: ROLARR trial: health economics data. Colorectal Disease. 2016;18.

  49. Heald RJ. A new solution to some old problems: transanal TME. Tech Coloproctol. 2013;17(3):257–8.

    Article  CAS  PubMed  Google Scholar 

  50. Atallah S, Martin-Perez B, Albert M, deBeche-Adams T, Nassif G, Hunter L, et al. Transanal minimally invasive surgery for total mesorectal excision (TAMIS-TME): results and experience with the first 20 patients undergoing curative-intent rectal cancer surgery at a single institution. Tech Coloproctol. 2014;18(5):473–80.

    Article  CAS  PubMed  Google Scholar 

  51. de Lacy AM, Rattner DW, Adelsdorfer C, Tasende MM, Fernandez M, Delgado S, et al. Transanal natural orifice transluminal endoscopic surgery (NOTES) rectal resection: “down-to-up” total mesorectal excision (TME)—short-term outcomes in the first 20 cases. Surg Endosc. 2013;27(9):3165–72.

    Article  PubMed  Google Scholar 

  52. Denost Q, Adam JP, Rullier A, Buscail E, Laurent C, Rullier E. Perineal transanal approach: a new standard for laparoscopic sphincter-saving resection in low rectal cancer, a randomized trial. Ann Surg. 2014;260(6):993–9.

    Article  PubMed  Google Scholar 

  53. Atallah S. Transanal total mesorectal excision: full steam ahead. Tech Coloproctol. 2015;19(2):57–61.

    Article  CAS  PubMed  Google Scholar 

  54. Buchs NC, Nicholson GA, Ris F, Mortensen NJ, Hompes R. Transanal total mesorectal excision: a valid option for rectal cancer? World J Gastroenterol. 2015;21(41):11700–8.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Simillis C, Hompes R, Penna M, Rasheed S, Tekkis PP. A systematic review of transanal total mesorectal excision: is this the future of rectal cancer surgery? Colorectal Dis. 2016;18(1):19–36.

    Article  CAS  PubMed  Google Scholar 

  56. Lacy AM, Tasende MM, Delgado S, Fernandez-Hevia M, Jimenez M, De Lacy B, et al. Transanal total mesorectal excision for rectal cancer: outcomes after 140 patients. J Am Coll Surg. 2015;221(2):415–23.

    Article  PubMed  Google Scholar 

  57. Deijen CL, Velthuis S, Tsai A, Mavroveli S, de Lange-de Klerk ES, Sietses C, et al. COLOR III: a multicentre randomised clinical trial comparing transanal TME versus laparoscopic TME for mid and low rectal cancer. Surg Endosc. 2015.

  58. Hompes R, Arnold S, Warusavitarne J. Towards the safe introduction of transanal total mesorectal excision: the role of a clinical registry. Colorectal Dis. 2014;16(7):498–501.

    Article  CAS  PubMed  Google Scholar 

  59. Fernandez-Hevia M, Delgado S, Castells A, Tasende M, Momblan D, Diaz del Gobbo G, et al. Transanal total mesorectal excision in rectal cancer: short-term outcomes in comparison with laparoscopic surgery. Ann Surg. 2015;261(2):221–7.

    Article  PubMed  Google Scholar 

  60. Coleman M, Rockall T. [Teaching of laparoscopic surgery colorectal. The Lapco model]. Cir Esp. 2013;91(5):279–80.

    Article  PubMed  Google Scholar 

  61. Coleman MG, Hanna GB, Kennedy R, National Training Programme L. The national training programme for laparoscopic colorectal surgery in England: a new training paradigm. Colorectal Dis. 2011;13(6):614–6.

    Article  CAS  PubMed  Google Scholar 

  62. Mackenzie H, Cuming T, Miskovic D, Wyles SM, Langsford L, Anderson J, et al. Design, delivery, and validation of a trainer curriculum for the national laparoscopic colorectal training program in England. Ann Surg. 2015;261(1):149–56.

    Article  PubMed  Google Scholar 

  63. Daniels IR, Fisher SE, Heald RJ, Moran BJ. Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence. Colorectal Dis. 2007;9(4):290–301.

    Article  CAS  PubMed  Google Scholar 

  64. Martling A, Cedermark B, Johansson H, Rutqvist LE, Holm T. The surgeon as a prognostic factor after the introduction of total mesorectal excision in the treatment of rectal cancer. Br J Surg. 2002;89(8):1008–13.

    Article  CAS  PubMed  Google Scholar 

  65. Wibe A, Moller B, Norstein J, Carlsen E, Wiig JN, Heald RJ, et al. A national strategic change in treatment policy for rectal cancer—implementation of total mesorectal excision as routine treatment in Norway. A national audit. Dis Colon Rectum. 2002;45(7):857–66.

    Article  PubMed  Google Scholar 

  66. Kapiteijn E, Putter H, van de Velde CJ. Impact of the introduction and training of total mesorectal excision on recurrence and survival in rectal cancer in The Netherlands. Br J Surg. 2002;89(9):1142–9.

    Article  CAS  PubMed  Google Scholar 

  67. Nielsen LB, Wille-Jorgensen P. National and international guidelines for rectal cancer. Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014;16(11):854–65.

    Article  CAS  Google Scholar 

  68. Moran BJ, Holm T, Brannagan G, Chave H, Quirke P, West N, et al. The English national low rectal cancer development programme: key messages and future perspectives. Colorectal Dis. 2014;16(3):173–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tom Cecil.

Ethics declarations

Grant Assistance

Not applicable.

Confirmation of Authorship

This is to confirm that Sanjeev Dayal, Nick Battersby and Tom Cecil meet the following guidelines as per the International Committee of Medical Journal Editors (ICMJE) for authorship of this article:

  1. 1.

    Substantial contributions to the conception and design of the work, analysis and interpretation of data both from personal experience and literature

  2. 2.

    Drafting the work or revising it critically for important intellectual content

  3. 3.

    Final approval of the version to be published

  4. 4.

    Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dayal, S., Battersby, N. & Cecil, T. Evolution of Surgical Treatment for Rectal Cancer: a Review. J Gastrointest Surg 21, 1166–1173 (2017). https://doi.org/10.1007/s11605-017-3427-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-017-3427-9

Keywords

Navigation