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Octreotide Does Not Prevent Pancreatic Fistula Following Pancreatoduodenectomy in Patients with Soft Pancreas and Non-dilated Duct: A Prospective Randomized Controlled Trial

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Whether octreotide prevents pancreatic fistula following pancreatoduodenectomy is controversial and it is believed to be beneficial in soft glands and normal-sized ducts. The aim of this study is to assess the potential value of octreotide in reducing the incidence of pancreatic fistula, postoperative complications, morbidity and hospital stay in patients with soft pancreas and non-dilated ducts.

Methods

A total of 109 patients undergoing elective pancreatoduodenectomy with soft pancreas and non-dilated duct were randomized to octreotide group versus no octreotide—the control group. Surgical steps were standardized and incidences of pancreatic fistula, complications, death and hospital stay were assessed.

Results

There were 55 patients in octreotide group and 54 in the control group. Demographic features and pancreatic duct diameter of the groups were comparable. The rates of clinically significant pancreatic fistulae (grades B and C) were 10.9 and 18.5 % (p = ns), and morbidity was 18 and 29.6 % (p = ns), respectively. Patients who received octreotide resumed oral diet early and had a shorter hospital stay.

Conclusion

This study demonstrated no statistical difference in pancreatic fistulae with the use of octreotide, though there was a trend towards fewer incidences of pancreatic fistulae, morbidity and shorter hospital stay.

ClinicalTrials.gov Identifier: NCT01301222

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The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of GI Surgery, PVS Memorial Hospital, Kaloor, Kochi, Kerala, India, 682017

    Prakash Kurumboor, Kamalesh Nadothottam Palaniswami, K. Pramil, Deepak George, Shaji Ponnambathayil, Deepak Varma & Sylesh Aikot

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  1. Prakash Kurumboor
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  2. Kamalesh Nadothottam Palaniswami
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  3. K. Pramil
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  5. Shaji Ponnambathayil
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Correspondence to Prakash Kurumboor.

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Kurumboor, P., Palaniswami, K.N., Pramil, K. et al. Octreotide Does Not Prevent Pancreatic Fistula Following Pancreatoduodenectomy in Patients with Soft Pancreas and Non-dilated Duct: A Prospective Randomized Controlled Trial. J Gastrointest Surg 19, 2038–2044 (2015). https://doi.org/10.1007/s11605-015-2925-x

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