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Clinical Presentations and Surgical Approach of Acute Intussusception Caused by Peutz–Jeghers Syndrome in Adults

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

Peutz–Jeghers syndrome is a rare autosomal dominantly inherited disease characterized by mucocutaneous pigmentations and gastrointestinal polyps. The polyps are located predominantly in the small intestine and usually cause intussusceptions. Adult intussusception caused by Peutz–Jeghers syndrome occurs very rarely. The purpose of this study was to analyze the clinical characteristics, preoperative diagnosis, and surgical management of Peutz–Jeghers syndrome associated with acute intussusception in adult patients.

Discussion

Consecutive patients with the postoperative diagnosis of acute intussusception caused by Peutz–Jeghers syndrome from 1995 to 2010 were reviewed retrospectively for this study. Data concerning clinical considerations, morphological examinations, and surgical procedure were analyzed. Different clinical manifestations were presented in patients with intussusception due to Peutz–Jeghers syndrome. Computed tomography associated or not with ultrasonography may be the most accurate examination for acute intussusceptions caused by Peutz–Jeghers syndrome. Surgical intervention is the first choice regimen in acute intussusceptions caused by Peutz–Jeghers syndrome. Prophylaxis and polypectomy of the entire small bowel is a worthy way in Peutz–Jeghers syndrome patients to reduce the frequency of laparotomies.

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Acknowledgment

The authors thank Zhang Zhang (Department of Pathology, West China Hospital, Sichuan University) for excellent technical support in pathology.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu, 610041, China

    Hong Wang & Xiao-Ting Wu

  2. Department of Geraeology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No. 1 Keyuan 4 Road, Gaopeng Street, High-Technological Development Zone, Chengdu, 610041, China

    Hong Wang & Xiu-Jie Wang

  3. Department of Medical Oncology, State Key Laboratory of Biotherapy and Cancer Center, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University, Chengdu, China

    Ting Luo

  4. Department of Internal Medicine, People’s Hospital of Anshun City, Anshun, China

    Wen-Qu Liu

  5. Department of Digestion Internal Medicine, the First Affiliated Hospital of Guiyang Medical College, Guiyang, China

    Yan Huang

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  1. Hong Wang
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  2. Ting Luo
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  3. Wen-Qu Liu
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  4. Yan Huang
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Correspondence to Xiao-Ting Wu or Xiu-Jie Wang.

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The author Ting Luo contributed equally to the work.

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Wang, H., Luo, T., Liu, WQ. et al. Clinical Presentations and Surgical Approach of Acute Intussusception Caused by Peutz–Jeghers Syndrome in Adults. J Gastrointest Surg 15, 2218–2225 (2011). https://doi.org/10.1007/s11605-011-1724-2

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  • DOI: https://doi.org/10.1007/s11605-011-1724-2

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