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Surgical Resection and Multidisciplinary Care for Primary and Metastatic Pancreatic Islet Cell Carcinomas

  • 2010 SSAT Poster Presentation
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

The role of multidisciplinary management of islet cell cancers (ICC) has not been fully investigated in a population-based setting.

Methods

The Los Angeles County Cancer Surveillance Program was assessed for patients with ICC between the years 1982 to 2006. Patients were stratified by treatment received and clinicopathologic characteristics and survival were compared.

Results

We identified 236 patients with ICC; 86 patients underwent curative-intent surgery with median survival for local, regional, and distant disease of 17.3, 12.2, and 4.0 years, respectively. In comparison, 102 patients underwent medical management alone; survival was significantly shorter when compared to the surgical cohort for local, regional, and distant disease (p < 0.05). To determine whether adjuvant chemotherapy was associated with improved survival, we compared patients who underwent surgery alone compared to patients who underwent surgery followed by adjuvant chemotherapy. Although patients with metastatic disease had 3-year longer survival with adjuvant chemotherapy, these improvements in survival were not statistically significant.

Conclusion

Surgical resection was associated with improved survival compared to medical management for any extent of disease in patients with ICC. Furthermore, adjuvant chemotherapy was not associated with survival but does warrant further examination in patients with metastatic disease.

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Acknowledgments

The authors acknowledge Nicola Solomon, Ph.D., for editorial assistance and critical review of the manuscript.

Financial Support

None.

This work was presented at the 51st Annual Meeting of The Society for Surgery of the Alimentary Tract; New Orleans, LA, 2010.

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Authors and Affiliations

  1. Department of Oncologic Surgery, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010, USA

    Shaun McKenzie, Wendy Lee, Brian Mailey, Alessio Pigazzi, Joshua Ellenhorn & Joseph Kim

  2. Michael E. Debakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA

    Avo Artinyan

Authors
  1. Shaun McKenzie
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  2. Wendy Lee
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  3. Avo Artinyan
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  4. Brian Mailey
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  7. Joseph Kim
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Correspondence to Joseph Kim.

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McKenzie, S., Lee, W., Artinyan, A. et al. Surgical Resection and Multidisciplinary Care for Primary and Metastatic Pancreatic Islet Cell Carcinomas. J Gastrointest Surg 14, 1796–1803 (2010). https://doi.org/10.1007/s11605-010-1225-8

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  • DOI: https://doi.org/10.1007/s11605-010-1225-8

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