Skip to main content
SpringerLink
Log in

Effects of Surgery on Peripheral N-Terminal Propeptide of Type III Procollagen in Patients with Crohn’s Disease

  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Aim

This study investigates the effects of surgery on collagen turnover in patients affected by Crohn’s disease (CD).

Methods

Fifteen patients affected by active CD, assessed according to the Crohn’s disease activity index, and confirmed by histology, with different pharmacological treatments, were enrolled in the study. N-Terminal propeptide of type III collagen was assessed on peripheral blood before and 6 months after surgery, as an index of collagen turnover. A control group of 15 healthy age- and sex-matched subjects was also studied.

Results

In CD patients peripheral N-terminal propeptide of type III collagen serum levels were significantly higher than in controls before surgery (5.0 ± 1.8 vs 2.7 ± 0.7 μg/l, respectively; p = 0.0001). Six months after these values were significantly reduced (from 5.0 ± 1.8 to 3.1 ± 0.8 μg/l; p = 0.003). Independently on the pretreatment regimen and the duration of the disease, an improvement in the patients’ symptoms was observed.

Conclusions

The surgical resection of the affected intestinal segment in CD patients seems to be able to break down the collagen synthesis processes. Peripheral N-terminal propeptide of type III collagen could be seen as an additive marker to clinical and endoscopic observations after surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

Similar content being viewed by others

References

  1. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998;115(1):182–205.

    Article  PubMed  CAS  Google Scholar 

  2. Knigge KL. Inflammatory bowel disease. Clin Cornerstone 2002;4(4):49–60.

    Article  PubMed  Google Scholar 

  3. Zheng CQ, Hu GZ, Zeng ZS, Lin LJ, Gu GG. Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning. World J Gastroenterol 2003;9(8):1646–56.

    PubMed  CAS  Google Scholar 

  4. Tamboli CP, Cortot A, Colombel JF. What are the major arguments in favour of the genetic susceptibility for inflammatory bowel disease? Eur J Gastoenterol Hepatol 2003;15(6):587–92.

    Article  CAS  Google Scholar 

  5. Hugot JP. Genetic origin of IBD. Inflamm Bowel Dis 2004;10(S1):S11–5.

    Article  PubMed  Google Scholar 

  6. Devani M, Cugno M, Vecchi M, Ferrero S, Di Berardino F, Avesani EC, de Franchis R, Colman RW. Kallikrein–kinin system activation in Crohn’s disease: differences in intestinal and systemic markers. Am J Gastroenterol 2002;97(8):2026–32.

    Article  PubMed  CAS  Google Scholar 

  7. Krishnan A, Korzenik JR. Inflammatory bowel disease and environmental influences. Gastroenterol Clin North Am 2002;31(1):21–39.

    Article  PubMed  Google Scholar 

  8. Isaacs KL, Lewis JD, Sandborn WJ, Sands BE, Targan SR. State of the art: IBD therapy and clinical trials in IBD. Inflamm Bowel Dis 2005;11(Suppl 1):S3–12.

    Article  PubMed  Google Scholar 

  9. Halfvarson J, Jess T, Magnuson A, Montgomery SM, Orholm M, Tysk C, Binder V, Jarnerot G. Environmental factors in inflammatory bowel disease: a co-twin control study of a Swedish–Danish twin population. Inflamm Bowel Dis 2006;12(10):925–33.

    Article  PubMed  Google Scholar 

  10. Ciulla M, Cioffi U, De Simone M, Contessini-Avesani E. TGF-beta1 and collagen metabolism in IBD patients. Med Sci Monit 2002;8(12):LE55–6.

    PubMed  Google Scholar 

  11. Hendrickson BA, Gokhale R, Cho JH. Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev 2002;15(1):79–94.

    Article  PubMed  Google Scholar 

  12. Chutkan RK. Inflammatory bowel disease. Prim Care 2001;28(3):539–56.

    PubMed  CAS  Google Scholar 

  13. Pucilowska JB, McNaughton KK, Mohapatra NK, Hoyt EC, Zimmermann EM, Sartor RB, Lund PK. IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn’s disease. Am J Physiol Gastrointest Liver Physiol 2000;279(6):G1307–22.

    PubMed  CAS  Google Scholar 

  14. Kjeldsen J, Schaffalitzky de Muckadell OB, Junker P. Seromarkers of collagen I and III metabolism in active Crohn’s disease. Relation to disease activity and response to therapy. Gut 1995;37(6):805–10.

    PubMed  CAS  Google Scholar 

  15. Kjeldsen J, Rasmussen M, Schaffalitzky de Muckadell OB, Kronborg O, Junker P. Collagen metabolites in the peripheral and splanchnic circulation of patients with Crohn disease. Scand J Gastroenterol 2001;36(11):1193–7.

    Article  PubMed  CAS  Google Scholar 

  16. Silvennoinen J, Risteli L, Karttunen T, Risteli J. Increased degradation of type I collagen in patients with inflammatory bowel disease. Gut 1996;38(2):223–8.

    PubMed  CAS  Google Scholar 

  17. Stallmach A, Schuppan D, Riese HH, Matthes H, Riecken EO. Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn’s disease. Gastroenterology 1992;102(6):1920–9.

    PubMed  CAS  Google Scholar 

  18. Hahn EG, Schuppan D. Ethanol and fibrinogenesis in the liver. In Seitz HK, Kommerell B, ed. Alcohol-related disease in gastroenterology. Berlin: Springer-Verlag, 1985, pp 124–53.

    Google Scholar 

  19. Uscanga L, Kennedy RH, Choux R, Druguet M, Grimaud JA, Sarles H. Sequential connective matrix changes in experimental acute pancreatitis. An immunohistochemical and biochemical assessment in the rat. Int J Pancreatol 1987;2(1):33–45.

    PubMed  CAS  Google Scholar 

  20. Cantin AM, Boileau R, Begin R. Increased procollagen III aminoterminal peptide-related antigens and fibroblast growth signals in the lungs of patients with idiopathic pulmonary fibrosis. Am Rev Respir Dis 1988;137(3):572–8.

    PubMed  CAS  Google Scholar 

  21. Querejeta R, Varo N, Lopez B, Larman M, Artinano E, Etayo JC, Martinez Ubago JL, Gutierrez-Stampa M, Emparanza JI, Gil MJ, Monreal I, Mindan JP, Diez J. Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease. Circulation 2000;101(14):1729–35.

    PubMed  CAS  Google Scholar 

  22. Sartorio A, Arosio M, Conti A, Ferrero S, Porretti S, Faglia G. Long-term monitoring of rec-GH treatment by serial determination of serum aminoterminal propeptide of type III procollagen in children and adults with GH deficiency. J Endocrinol Invest 1999;22(3):169–75.

    PubMed  CAS  Google Scholar 

  23. De Simone M, Cioffi U, Contessini-Avesani E, Oreggia B, Paliotti R, Pierini A, Bolla G, Oggiano E, Ferrero S, Magrini F, Ciulla MM. Elevated serum procollagen type III peptide in splanchnic and peripheral circulation of patients with inflammatory bowel disease submitted to surgery. BMC Gastroenterol 2004;4(4):29.

    Article  PubMed  Google Scholar 

  24. Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn’s disease activity index. National Cooperative Crohn’s Disease Study. Gastroenterology 1976;70(3):439–44.

    PubMed  CAS  Google Scholar 

  25. Longobardi T, Jacobs P, Bernstein CN. Work losses related to inflammatory bowel disease in the United States: results from the National Health Interview Survey. Am J Gastroenterol 2003;98(5):1064–72.

    PubMed  Google Scholar 

  26. Stange EF, Travis SP, Vermeire S, Beglinger C, Kupcinkas L, Geboes K, Barakauskiene A, Villanacci V, Von Herbay A, Warren BF, Gasche C, Tilg H, Schreiber SW, Scholmerich J, Reinisch W, European Crohn’s and Colitis Organisation. European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. Gut 2006;55(1):i1–15.

    Article  PubMed  Google Scholar 

  27. Russell RK, Satsangi J. IBD: a family affair. Best Pract Res Clin Gastroenterol 2004;18(3):525–39.

    Article  PubMed  CAS  Google Scholar 

  28. Marks DJ, Harbord MW, MacAllister R, Rahman FZ, Young J, Al-Lazikani B, Lees W, Novelli M, Bloom S, Segal AW. Defective acute inflammation in Crohn’s disease: a clinical investigation. Lancet 2006;367(9511):668–78.

    Article  PubMed  CAS  Google Scholar 

  29. Caprilli R, Gassull MA, Escher JC, Moser G, Munkholm P, Forbes A, Hommes DW, Lochs H, Angelucci E, Cocco A, Vucelic B, Hildebrand H, Kolacek S, Riis L, Lukas M, de Franchis R, Hamilton M, Jantschek G, Michetti P, O’Morain C, Anwar MM, Freitas JL, Mouzas IA, Baert F, Mitchell R, Hawkey CJ; European Crohn’s and Colitis Organisation. European evidence based consensus on the diagnosis and management of Crohn’s disease: special situations. Gut 2006;55(1):i36–58.

    Article  PubMed  Google Scholar 

  30. Dubinsky MC, Seidman EG. Diagnostic markers of inflammatory bowel disease. Curr Opin Gastroenterol 2000;16(4):337–42.

    Article  PubMed  CAS  Google Scholar 

  31. Colombel JF, Solem CA, Sandborn WJ, Booya F, Loftus EV Jr, Harmsen WS, Zinsmeister AR, Bodily KD, Fletcher JG. Quantitative measurement and visual assessment of ileal Crohn’s disease activity by computed tomography enterography: correlation with endoscopic severity and C reactive protein. Gut 2006;55(11):1561–7.

    Article  PubMed  CAS  Google Scholar 

  32. Cioffi U, Ciulla MM, De Simone M, Paliotti R, Pierini A, Magrini F, Botti F, Contessini-Avesani E. Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol. BMC Public Health 2002;10(2):9.

    Article  Google Scholar 

  33. Sartorio A, Conti A, Ferrero S, Giambona S, Re T, Passini E, Ambrosi B. Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing’s syndrome and in patients with adrenal incidentaloma. Eur J Endocrinol 1998;138(2):146–52.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy

    Matilde De Simone, Ugo Cioffi, Luca Poggi, Barbara Oreggia, Fiorenzo Botti, Alberto Carrara & Ettore Contessini-Avesani

  2. Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy

    Michele M. Ciulla & Roberta Paliotti

  3. Divisione Malattie Metaboliche III, Istituto Auxologico Italiano, IRCCS, Milano e Piancavallo (VB), Milan, Italy

    Fiorenza Agosti & Alessandro Sartorio

  4. Laboratorio Sperimentale di Ricerche Auxo-Endocrinologiche (LSRE), Istituto Auxologico Italiano, IRCCS, Milano e Piancavallo (VB), Milan, Italy

    Fiorenza Agosti & Alessandro Sartorio

Authors
  1. Matilde De Simone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michele M. Ciulla
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ugo Cioffi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Luca Poggi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Barbara Oreggia
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Roberta Paliotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Fiorenzo Botti
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alberto Carrara
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Fiorenza Agosti
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Alessandro Sartorio
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Ettore Contessini-Avesani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matilde De Simone.

Rights and permissions

Reprints and permissions

About this article

Cite this article

De Simone, M., Ciulla, M.M., Cioffi, U. et al. Effects of Surgery on Peripheral N-Terminal Propeptide of Type III Procollagen in Patients with Crohn’s Disease. J Gastrointest Surg 11, 1361–1364 (2007). https://doi.org/10.1007/s11605-007-0233-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-007-0233-9

Keywords

Search

Navigation