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Selective intraarterial chemoradiation therapy for oropharyngeal carcinoma with high-dose cisplatin

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

Cisplatin has shown a high tumor response rate among head and neck carcinomas, and the tumor response is related to the cisplatin dosage. The purpose of this study was to evaluate the efficacy and toxicity of selective intraarterial chemoradiation therapy for oropharyngeal carcinomas with high-dose cisplatin.

Materials and methods

This retrospective study consisted of 21 patients with oropharyngeal carcinoma, stages II-IVB, in whom intraarterial chemoradiation therapy was performed between 2000 and 2008. All patients were given two courses of selective intraarterial infusions of cisplatin (300 mg/m2), systemic chemotherapy with 5-fluorouracil, and simultaneous radiation therapy (58–61 Gy/30 fractions), with a 1-week rest period.

Results

The 2-year overall survival rate of the 15 patients who completed the therapeutic regimen was 71.3%. The 2-year locoregional control rate and disease-free survival rate were 95.0% and 67.7%, respectively.

Conclusion

Selective intraarterial high-dose cisplatin chemotherapy with concomitant radiation therapy shows results similar to those of original methods in terms of survival and locoregional control with a reduction in the number of procedure times.

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References

  1. Hart AA, Mak-Kregar S, Hilgers FJ, Levendag PC, Manni JJ, Spoelstra HA, et al. The importance of correct stage grouping in oncology: results of a nationwide study of oropharyngeal carcinoma in The Netherlands. Cancer 1995;75:2656–2662.

    Article  PubMed  CAS  Google Scholar 

  2. Laramore GE, Scott CB, al-Sarraf M, Haselow RE, Ervin TJ, Wheeler R, et al. Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup Study 0034. Int J Radiat Oncol Biol Phys 1992;23:705–713.

    Article  PubMed  CAS  Google Scholar 

  3. Marcial VA, Pajak TF. Radiation therapy alone or in combination with surgery in head and neck cancer. Cancer 1985;55:2259–2265.

    Article  PubMed  CAS  Google Scholar 

  4. Licitra L, Bernier J, Grandi C, Merlano M, Bruzzi P, Lefebvre JL. Cancer of the oropharynx. Crit Rev Oncol Hematol 2002;41:107–122.

    Article  PubMed  Google Scholar 

  5. Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004;350:1945–1952.

    Article  PubMed  CAS  Google Scholar 

  6. Taylor SG, Murthy AK, Caldarelli DD, Showel JL, Kiel K, Griem KL, et al. Combined simultaneous cisplatin/fluorouracil chemotherapy and split course radiation in head and neck cancer. J Clin Oncol 1989;7:846–856.

    PubMed  Google Scholar 

  7. Murthy AK, Taylor SG, Showel J, Caldarelli DD, Hutchinson JC Jr, Holinger LD, et al. Treatment of advanced head and neck cancer with concomitant radiation and chemotherapy. Int J Radiat Oncol Biol Phys 1987;13:1807–1813.

    Article  PubMed  CAS  Google Scholar 

  8. Adelstein DJ, Sharan VM, Earle AS, Shah AC, Vlastou C, Haria CD, et al. Long-term results after chemoradiotherapy for locally confined squamous-cell head and neck cancer. Am J Clin Oncol 1990;13:440–447.

    Article  PubMed  CAS  Google Scholar 

  9. Rooney M, Kish J, Jacobs J, Kinzie J, Weaver A, Crissman J, et al. Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-hour 5-FU infusion and cisplatin. Cancer 1985;55:1123–1128.

    Article  PubMed  CAS  Google Scholar 

  10. Dreyfuss AI, Clark JR, Wright JE, Norris CM Jr, Busse PM, Lucarini JW, et al. Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Ann Intern Med 1990;112:167–172.

    PubMed  CAS  Google Scholar 

  11. Robbins KT, Hoffman RM. “Decadose” effects of cisplatin on squamous cell carcinoma of the upper aerodigestive tract. I. Histoculture experiments. Laryngoscope 1996;106:32–36.

    Article  PubMed  CAS  Google Scholar 

  12. Robbins KT, Storniolo AM, Hryniuk WM, Howell SB. “Decadose” effects of cisplatin on squamous cell carcinoma of the upper aerodigestive tract. II. Clinical studies. Laryngoscope 1996;106:37–42.

    Article  PubMed  CAS  Google Scholar 

  13. Robbins KT, Kumar P, Wong FS, Hartsell WF, Flick P, Palmer R, et al. Targeted chemoradiation for advanced head and neck cancer: analysis of 213 patients. Head Neck 2000;22:687–693.

    Article  PubMed  CAS  Google Scholar 

  14. Robbins KT, Fontanesi J, Wong FS, Vicario D, Seagren S, Kumar P, et al. A novel organ preservation protocol for advanced carcinoma of the larynx and pharynx. Arch Otolaryngol Head Neck Surg 1996;122:853–857.

    PubMed  CAS  Google Scholar 

  15. Robbins KT, Storniolo AM, Kerber C, Vicario D, Seagren S, Shea M, et al. Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer. J Clin Oncol 1994;12:2113–2120.

    PubMed  CAS  Google Scholar 

  16. Korogi Y, Hirai T, Nishimura R, Hamatake S, Sakamoto Y, Murakami R, et al. Superselective intraarterial infusion of cisplatin for squamous cell carcinoma of the mouth: preliminary clinical experience. AJR Am J Roentgenol 1995;165:1269–1272.

    PubMed  CAS  Google Scholar 

  17. Ishii A, Korogi Y, Nishimura R, Kawanaka K, Yamura M, Ikushima I, et al. Intraarterial infusion chemotherapy for head and neck cancers: evaluation of tumor perfusion with intraarterial CT during carotid arteriography. Radiat Med 2004;22:254–259.

    PubMed  Google Scholar 

  18. Robbins KT, Storniolo AM, Kerber C, Seagren S, Berson A, Howell SB. Rapid superselective high-dose cisplatin infusion for advanced head and neck malignancies. Head Neck 1992;14:364–371.

    Article  PubMed  CAS  Google Scholar 

  19. Robbins KT, Samant S, Vieira F, Kumar P. Presurgical cytoreduction of oral cancer using intra-arterial cisplatin and limited concomitant radiation therapy (Neo-RADPLAT). Arch Otolaryngol Head Neck Surg 2004;130:28–32.

    Article  PubMed  Google Scholar 

  20. Robbins KT, Vicario D, Seagren S, Weisman R, Pellitteri P, Kerber C, et al. A targeted supradose cisplatin chemoradiation protocol for advanced head and neck cancer. Am J Surg 1994;168:419–422.

    Article  PubMed  CAS  Google Scholar 

  21. Robbins KT, Kumar P, Regine WF, Wong FS, Weir AB 3rd, Flick P, et al. Efficacy of targeted supradose cisplatin and concomitant radiation therapy for advanced head and neck cancer: the Memphis experience. Int J Radiat Oncol Biol Phys 1997;38:263–271.

    Article  PubMed  CAS  Google Scholar 

  22. Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P, et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advancedstage oropharynx carcinoma. J Natl Cancer Inst 1999;91:2081–2086.

    Article  PubMed  CAS  Google Scholar 

  23. Barkati M, Fortin B, Soulieres D, Clavel S, Despres P, Charpentier D, et al. Concurrent chemoradiation with carboplatin-5-fluorouracil versus cisplatin in locally advanced oropharyngeal cancers: is more always better? Int J Radiat Oncol Biol Phys 76:410–416.

  24. Rasch CR, Hauptmann M, Schornagel J, Wijers O, Buter J, Gregor T, et al. Intra-arterial versus intravenous chemoradiation for advanced head and neck cancer: results of a randomized phase 3 trial. Cancer 116:2159–2165.

  25. Kakeda S, Korogi Y, Miyaguni Y, Moriya J, Ohnari N, Oda N, et al. A cone-beam volume CT using a 3D angiography system with a flat panel detector of direct conversion type: usefulness for superselective intra-arterial chemotherapy for head and neck tumors. AJNR Am J Neuroradiol 2007;28:1783–1788.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Ryota Nishio, Kazuhiro Saito, Naoto Kanesaka, Ryuji Mikami, Daisuke Hasegawa & Koichi Tokuuye

  2. Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan

    Hiroyuki Ito, Tomoyuki Yoshida, Koichi Kitamura, Akira Shimizu & Mamoru Suzuki

Authors
  1. Ryota Nishio
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  2. Kazuhiro Saito
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  3. Hiroyuki Ito
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  4. Tomoyuki Yoshida
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  5. Koichi Kitamura
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  6. Akira Shimizu
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  7. Naoto Kanesaka
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  8. Ryuji Mikami
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  9. Daisuke Hasegawa
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  10. Mamoru Suzuki
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  11. Koichi Tokuuye
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Corresponding author

Correspondence to Kazuhiro Saito.

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Cite this article

Nishio, R., Saito, K., Ito, H. et al. Selective intraarterial chemoradiation therapy for oropharyngeal carcinoma with high-dose cisplatin. Jpn J Radiol 29, 570–575 (2011). https://doi.org/10.1007/s11604-011-0599-1

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  • DOI: https://doi.org/10.1007/s11604-011-0599-1

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