Abstract
Purpose
The aim of this study was to compare age-related bone losses and correlations among several bone mass measurements and to evaluate diagnostic agreement among them using the Japanese and WHO criteria for osteoporosis.
Materials and methods
A total of 846 women (mean ± SD: age 54 ± 9 years) were evaluated. Bone mineral densities of the lumbar spine, femoral neck, and calcaneus were measured by dual X-ray absorptiometry and distal radius by peripheral computed tomography. Quantitative ultrasonography (QUS) parameters of the calcaneus were also measured. The age-related bone losses after 50 years of age and correlations among bone mass results were evaluated using linear regression analysis. Diagnostic agreement was evaluated by kappa statistics.
Results
The annual losses ranged from 1.0% to 1.6%. The correlation coefficients ranged from 0.54 to 0.78. The kappa scores ranged from 0.52 to 0.30 for all subjects using the Japanese criteria and from 0.38 to 0.15 using the WHO criteria.
Conclusion
Bone mass measurements including QUS on various skeletal sites documented age-related changes similarly, and their bone masses correlated moderately. The diagnostic agreements among them were fair to poor. To screen out women with a risk of osteoporosis, it is important to choose which technique to use and which skeletal site to measure.
Similar content being viewed by others
References
JA Kanis LJ Melton SuffixIII CC Christiansen CC Johnston N Khaltaer (1994) ArticleTitleThe diagnosis of osteoporosis J Bone Miner Res 9 1137–41 Occurrence Handle7976495 Occurrence Handle1:STN:280:DyaK2M%2FmslSisA%3D%3D
HK Genant K Engelke T Fuerst CC Gluer S Grampp ST Harris et al. (1996) ArticleTitleNon-invasive assessment of bone mineral and structure: state of the art J Bone Miner Res 11 707–70 Occurrence Handle8725168 Occurrence Handle1:STN:280:DyaK28zmtl2gtA%3D%3D Occurrence Handle10.1002/jbmr.5650110602
InstitutionalAuthorNameOsteoporosis Diagnostic Criteria Review Committee, Japanese Society for Bone and Mineral Research (1996) ArticleTitleDiagnostic criteria for primary osteoporosis: year 1996 revision Osteoporos Jpn 4 644–52
InstitutionalAuthorNameOsteoporosis Diagnostic Criteria Review Committee, Japanese Society for Bone and Mineral Research (2001) ArticleTitleDiagnostic criteria for primary osteoporosis: year 2000 revision J Bone Miner Metab 19 331–7 Occurrence Handle10.1007/s007740170001
S Grampp HK Genant A Mathur P Lang M Jergas M Takada et al. (1997) ArticleTitleComparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification J Bone Miner Rees 12 697–711 Occurrence Handle10.1359/jbmr.1997.12.5.697 Occurrence Handle1:STN:280:DyaK2s3ovFCgsg%3D%3D
Y Lu HK Genant J Shepherd S Zhao A Mathur TP Fuerst et al. (2001) ArticleTitleClassification of osteoporosis based on bone mineral densities J Bone Miner Res 16 901–10 Occurrence Handle11341335 Occurrence Handle10.1359/jbmr.2001.16.5.901 Occurrence Handle1:STN:280:DC%2BD38%2FgvFaksA%3D%3D
ED Williams TJ Daymond (2003) ArticleTitleEvaluation of calcaneus bone densitometry against hip and spine for diagnosis of osteoporosis Br J Radiol 76 123–8 Occurrence Handle12642281 Occurrence Handle10.1259/bjr/56105358 Occurrence Handle1:STN:280:DC%2BD3s7islKktg%3D%3D
S Grampp CB Henk TP Fuerst Y Lu TR Bader F Kainberger et al. (1999) ArticleTitleDiagnostic agreement of quantitative sonography of the calcaneus with dual X-ray absorptiometry of the spine and femur AJR Am J Roentgenol 173 329–33 Occurrence Handle10430129 Occurrence Handle1:STN:280:DyaK1MzlslWqug%3D%3D
CR Krestan S Grampp A Resch-Holeczke CB Henk H Imhof H Resch (2001) ArticleTitleDiagnostic disagreement of imaging quantitative sonography of the calcaneus with dual X-ray absorptiometry of the spine and femur AJR Am J Roentgenol 177 213–6 Occurrence Handle11418431 Occurrence Handle1:STN:280:DC%2BD3Mzlslemuw%3D%3D
FM Lomoschitz S Grampp CB Henk KF Linnau CR Kresta H Resch et al. (2003) ArticleTitleComparison of imaging-guided and non-imaging-guided quantitative sonography of the calcaneus with dual X-ray absorptiometry of the spine and femur AJR Am J Roentgenol 180 1111–6 Occurrence Handle12646464 Occurrence Handle1:STN:280:DC%2BD3s7jtF2itw%3D%3D
K Kim SuffixII IK Han H Kim NH Cho (2001) ArticleTitleHow reliable is the ultrasound densitometer for community screening to diagnose osteoporosis in spine, femur, and forearm? J Clin Densitom 4 159–65 Occurrence Handle11486785 Occurrence Handle10.1385/JCD:4:2:159 Occurrence Handle1:STN:280:DC%2BD3MvktVOhtA%3D%3D
FE Alenfeld K Engelke D Schmidt M Brezger E Diessel D Felsenberg (2002) ArticleTitleDiagnostic agreement of two calcaneal ultrasound devices: the Sahara bone sonometer and the Achilles+ Br J Radiol 75 895–902 Occurrence Handle12466255 Occurrence Handle1:STN:280:DC%2BD38jgsVOqsg%3D%3D
D Hans AM Schott MC Chapuy M Benamar PD Kotzki C Cormier et al. (1996) ArticleTitleUltrasound measurements on the os calcis in a prospective multicenter study Calcif Tissue Int 55 94–9 Occurrence Handle10.1007/BF00297182
K Yamazaki K Kushida A Ohmura M Sano T Inoue (1997) ArticleTitleUltrasound bone densitometry of the os calcis in Japanese women Osteoporos Int 4 220–5 Occurrence Handle10.1007/BF01623242
S Sakata K Kushida K Yamazaki T Inoue (1997) ArticleTitleEstablishment of diagnostic threshold for the calcaneal quantitative ultrasound from the population based data Nippon Kotsutaisya Gakkaizasshi 15 28s
I Yamamoto R Matsushita Y Yamamura T Ota Y Kigami I Yuu et al. (1996) ArticleTitleBone mineral measurement of os calcis with dual x-ray absorptiometry: determination of normal ranges in Japanese adults J Jpn Soc Bone Morphom 6 279–85
Y Hamanaka I Yamamoto M Takada R Matsushita T Ota I Yuh et al. (1999) ArticleTitleComparison of bone mineral density at various skeletal sites with quantitative ultrasound parameters of the calcaneus for assessment of vertebral fractures J Bone Miner Metab 17 195–200 Occurrence Handle10757679 Occurrence Handle10.1007/s007740050084 Occurrence Handle1:STN:280:DC%2BD3c3hvVKhug%3D%3D
PD Miller FN Christopher LG Jankowski L Lenchik (2002) ArticleTitleWhat are the standards by which bone mass measurements at peripheral skeletal sites should be used in the diagnosis of osteoporosis? J Clin Densitom 5 s39–4 Occurrence Handle12464710 Occurrence Handle10.1385/JCD:5:3S:S39
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Imashuku, Y., Takada, M. & Murata, K. Comparisons of bone mass measurements on various skeletal sites including quantitative ultrasonography of the calcaneus for assessing age-related losses, their correlations, and diagnostic agreement using the Japanese and WHO criteria for osteoporosis. Radiat Med 25, 148–154 (2007). https://doi.org/10.1007/s11604-006-0117-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11604-006-0117-z