Abstract
Purpose
It is generally assumed that vascular tracer activity is negligible in the quantification of regional cerebral blood flow (rCBF) with H2 15O and positron emission tomography (PET) under normal conditions. We attempted to surpass the assumption of abnormal vascular conditions where the vascular tracer activity is significant by introducing the vascular component into the model.
Materials and methods
H2 15O-dynamic and C15O PET scans were performed in an arteriovenous fistula (AVF) patient. Time–activity curves of regions of interest (ROIs) were analyzed with nonlinear least-square approximation to estimate the rCBF and fractional arterial blood volume (va) simultaneously with the proposed model and the standard model.
Results
The proposed model curve showed a fit to the time–activity curve of H2 15O at an ROI containing an enlarged vascular space induced by the AVF. The relation between the estimated va and CBV obtained with C15O-PET revealed that the ratio of va to CBV was approximately 0.23. The estimated rCBF with the proposed model in nonlesion ROIs corresponded to those of the standard model, with the estimated Vd 0.94 ml/ml.
Conclusion
The results supported the hypothesis that the blood volume-corrected model is applicable to the quantification of rCBF in a region with abnormal vascular structure. Furthermore, one of the advantages of the model is the feasibility of simultaneous estimation of the rCBF and arterial blood volume with dynamic-H2 15O PET scans.
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References
P Herscovitch J Markham ME Raichle (1983) ArticleTitleBrain blood flow measured with intravenous H2 15O. I. Theory and error analysis J Nucl Med 24 782–9 Occurrence Handle6604139 Occurrence Handle1:STN:280:BiyB1MzlvFM%3D
ME Raichle WRW Martin P Herscovitch MA Mintum J Markham (1983) ArticleTitleBrain blood flow measured with intravenous H2 15O. II. Implementation and validation J Nucl Med 24 790–8 Occurrence Handle6604140 Occurrence Handle1:STN:280:BiyB1MzlvFw%3D
SS Kety CE Schmidt (1948) ArticleTitleThe nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values J Clin Invest 27 476–83 Occurrence Handle16695568 Occurrence Handle1:STN:280:DC%2BD28zhtVGmtQ%3D%3D Occurrence Handle10.1172/JCI101994
SS Kety (1960) Blood-tissue exchange and its application to measurement of blood flow Methods on medical research Year Book Chicago 223–7
A Gjedde (1988) Concluding remarks M Tomita T Sawada H Naritomi W-D Heiss (Eds) Cerebral hyperemia and ischemia: from the standpoint of cerebral blood volume Excerpta Medica Elsevier Science Amsterdam 277–80
S Ohta E Meyer H Fujita DC Reutens A Evans A Gjedde (1996) ArticleTitleCerebral [15O]water clearance In humans determined by PET. I. Theory and normal values J Cereb Blood Flow Metab 16 765–80 Occurrence Handle8784222 Occurrence Handle1:STN:280:BymA2sfmsF0%3D Occurrence Handle10.1097/00004647-199609000-00002
H Ito I Kanno H Iida J Hatazawa E Shimisegawa H Tamura et al. (2001) ArticleTitleArterial fraction of cerebral blood volume in humans measured by positron emission tomography Ann Nucl Med 15 111–6 Occurrence Handle11448068 Occurrence Handle1:STN:280:DC%2BD38%2FitVagsw%3D%3D
P Herscovitch ME Raichle (1985) ArticleTitleWhat is the correct value for the brain-blood partition coefficient for water? J Cereb Blood Flow Metab 5 65–9 Occurrence Handle3871783 Occurrence Handle1:STN:280:BiqC3s7jvFI%3D
WH Press BP Flannery SA Teukolsky WT Vetterling (1989) Integration of ordinary differential equations Numerical recipes in PASCAL Cambridge University Press Cambridge 599–632
WH Press BP Flannery SA Teukolsky WT Vetterling (1989) Modeling of data Numerical recipes in PASCAL Cambridge University Press Cambridge 547–98
H Iida S Miura I Kanno M Murakami K Takahashi K Uemura et al. (1989) ArticleTitleDesign and evaluation of HEADTOME-IV, a whole-body positron emission tomography IEEE Trans Nucl Sci 37 1006–10 Occurrence Handle10.1109/23.34594
H Iida I Kanno A Inugami S Miura M Murakami K Takahashi et al. (1987) ArticleTitleContinuous-monitoring detector-system of arterial H2 15O concentration for positron-emission tomography: construction of the system and correction for the dispersion and the time-shift Jpn J Nucl Med 24 1587–94 Occurrence Handle1:STN:280:BieC2Mrpslc%3D
H Akaike (1974) ArticleTitleA new look at the statistical model identification IEEE Trans Automat Conntr AC 19 716–23 Occurrence Handle10.1109/TAC.1974.1100705
H Iida S Higano N Tomura F Shidano I Kanno S Miura et al. (1988) ArticleTitleEvaluation of regional differences of tracer appearance time in cerebral tissues using [15O] water and dynamic positron emission tomography J Cereb Blood Flow Metab 8 285–8 Occurrence Handle3257762 Occurrence Handle1:STN:280:BieC3sblsVQ%3D
JO Eichling ME Raichle RL Grubb MM Ter-Pogossian (1974) ArticleTitleEvidence of the limitation of water as a freely diffusible water in brain of the rhesus monkey Circ Res 35 358–64 Occurrence Handle4419687 Occurrence Handle1:STN:280:CSqD38zisFQ%3D
P Herscovitch ME Raichle MR Kilbourn MJ Welch (1987) ArticleTitlePositron emission tomographic measurement of cerebral blood flow and permeability-surface area product of water using [15O] water and [11C] butanol J Cereb Blood Flow Metab 7 527–42 Occurrence Handle3498732 Occurrence Handle1:STN:280:BieD3cjpvF0%3D
EM Renkin (1959) ArticleTitleTransport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles Am J Physiol 197 1205–10 Occurrence Handle14437359 Occurrence Handle1:CAS:528:DyaF3cXksFKqug%3D%3D
C Crone (1963) ArticleTitleThe permeability of capillaries in various organs as determined by use of indicator diffusion method Acta Physiol Scand 58 292–305 Occurrence Handle14078649 Occurrence Handle1:STN:280:CCuD3snivFQ%3D Occurrence Handle10.1111/j.1748-1716.1963.tb02652.x
H Iida I Kanno S Miura M Murakami K Takahashi K Uemura (1986) ArticleTitleError analysis of a quantitative measurement using H2 15O autoradiography and positron emission tomography, with respect to the dispersion of the input function J Cereb Blood Flow Metab 6 536–45 Occurrence Handle3489723 Occurrence Handle1:STN:280:BiiD3cfntlI%3D
J Van den Hoff W Burchert W MÜller-Schauenburg GJ Meyer H Hundeshagen (1993) ArticleTitleAccurate local blood flow measurements with dynamic PET: fast determination of input function delay and dispersion by multilinear minimization J Nucl Med 34 1770–7 Occurrence Handle8410297 Occurrence Handle1:STN:280:ByuD3MrktlE%3D
H Okazawa Y Yonekura N Sadato H Lyshkow S Nishizawa R Asato et al. (1996) ArticleTitleDelayed data acquisition for optimal PET activation studies with oxygen-15-water in cerebral arteriovenous malformation J Nucl Med 36 2149–53
K Chen EM Reiman M Lawson L Yun A Bandy A Palant (1996) ArticleTitleMethods for the correction of vascular artifacts in PET O-15 water brain-mapping studies IEEE Trans Nucl Sci 43 3308–14 Occurrence Handle10.1109/23.552742
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Seki, C., Momose, T., Kojima, Y. et al. Proposal of blood volume-corrected model for quantification of regional cerebral blood flow with H2 15O-PET and its application to AVF. Radiat Med 24, 260–268 (2006). https://doi.org/10.1007/s11604-005-1547-8
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DOI: https://doi.org/10.1007/s11604-005-1547-8