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Nomograms for Predicting Cancer-Specific Survival of Patients with Gingiva Squamous Cell Carcinoma: A Population-Based Study

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Abstract

Objective

The use of the traditional American Joint Committee on Cancer (AJCC) staging system alone has limitations in predicting the survival of gingiva squamous cell carcinoma (GSCC) patients. We aimed to establish a comprehensive prognostic nomogram with a prognostic value similar to the AJCC system.

Methods

Patients were identified from SEER database. Variables were selected by a backward stepwise selection method in a Cox regression model. A nomogram was used to predict cancer-specific survival rates for 3, 5 and 10 years in patients with GSCC. Several basic features of model validation were used to evaluate the performance of the survival model: consistency index (C-index), receiver operating characteristic (ROC) curve, calibration chart, net weight classification improvement (NRI), comprehensive discriminant improvement (IDI) and decision curve analysis (DCA).

Results

Multivariate analyses revealed that age, race, marital status, insurance, AJCC stage, pathology grade and surgery were risk factors for survival. In particular, the C-index, the area under the ROC curve (AUC) and the calibration plots showed good performance of the nomogram. Compared to the AJCC system, NRI and IDI showed that the nomogram has improved performance. Finally, the nomogram’s 3-year and 5-year and 10-year DCA curves yield net benefits higher than traditional AJCC, whether training set or a validation set.

Conclusion

We developed and validated the first GSCC prognosis nomogram, which has a better prognostic value than the separate AJCC staging system. Overall, the nomogram of this study is a valuable tool for clinical practice to consult patients and understand their risk for the next 3, 5 and 10 years.

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Author notes

  1. The authors contributed equally to this work.

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, 410008, China

    Si-si Yang, An-jie Min & Wei-ming Wang

  2. Department of Orthodontics, Center of Stomatology, Xiangya Hospital of Central South University, Changsha, 410008, China

    Xiao-huan Zhong & Hui-xin Wang

Authors
  1. Si-si Yang
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  2. Xiao-huan Zhong
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  3. Hui-xin Wang
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  4. An-jie Min
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  5. Wei-ming Wang
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Corresponding author

Correspondence to Wei-ming Wang.

Additional information

This project was supported by grants from National Natural Science Foundation of China (No. 81702708), Natural Science Foundation of Hunan Province (No. 2018JJ3862, No. 2017JJ2392, and No. 2019JJ50979), Scientific Research Project of Hunan Provincial Health Commission (No. B20180054) and Changsha Science and Technology Project (No. kq1706072).

Conflict of Interest Statement

The authors declare that there are no conflicts of interests.

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Yang, Ss., Zhong, Xh., Wang, Hx. et al. Nomograms for Predicting Cancer-Specific Survival of Patients with Gingiva Squamous Cell Carcinoma: A Population-Based Study. CURR MED SCI 41, 953–960 (2021). https://doi.org/10.1007/s11596-021-2435-x

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  • DOI: https://doi.org/10.1007/s11596-021-2435-x

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