Abstract
Oscillatory activity of retinal ganglion cell (RGC) has been observed in various species. It was reported such oscillatory activity is raised within large neural network and involved in retinal information coding. In the present research, we found an oscillation-like activity in ON–OFF RGC of bullfrog retina, and studied the mechanisms underlying the ON and OFF activities respectively. Pharmacological experiments revealed that the oscillation-like activity patterns in both ON and OFF pathways were abolished by GABA receptor antagonists, indicating GABAergic inhibition is essential for generating them. At the meantime, such activities in the ON and OFF pathways showed different responses to several other applied drugs. The oscillation-like pattern in the OFF pathway was abolished by glycine receptor antagonist or gap junction blocker, whereas that in the ON pathway was not affected. Furthermore, the blockade of the ON pathway by metabotropic glutamate receptor agonist led to suppression of the oscillation-like pattern in the OFF pathway. These results suggest that the ON pathway has modulatory effect on the oscillation-like activity in the OFF pathway. Therefore, the mechanisms underlying the oscillation-like activities in the ON and OFF pathways are different: the oscillation-like activity in the ON pathway is likely caused by GABAergic amacrine cell network, while that in the OFF pathway needs the contributions of GABAergic and glycinergic amacrine cell network, as well as gap junction connections.
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Acknowledgments
This work was supported by grants from the National Natural Science Foundation of China (No. 31471054, P.J.L; No. 61375114, P.M.Z).
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All experimental procedures were performed according to the humane treatment and use of animals as prescribed by the Association for Research in Vision and Ophthalmology, and were approved by the Ethic Committee, School of Biomedical Engineering, Shanghai Jiao Tong University.
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Qiu, XW., Gong, HQ., Zhang, PM. et al. The oscillation-like activity in bullfrog ON–OFF retinal ganglion cell. Cogn Neurodyn 10, 481–493 (2016). https://doi.org/10.1007/s11571-016-9397-x
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DOI: https://doi.org/10.1007/s11571-016-9397-x