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Radioactive seed immobilization techniques for interstitial brachytherapy

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

In prostate brachytherapy, seeds can detach from their deposited sites and move locally in the pelvis or migrate to distant sites including the pulmonary and cardiac regions. Undesirable consequences of seed migration include inadequate dose coverage of the prostate and tissue irradiation effects at the site of migration. Thus, it is clinically important to develop seed immobilization techniques.

Methods

We first analyze the possible causes for seed movement, and propose three potential techniques for seed immobilization: (1) surgical glue, (2) laser coagulation and (3) diathermy coagulation. The feasibility of each method is explored. Experiments were carried out using fresh bovine livers to investigate the efficacy of seed immobilization using surgical glue.

Results

Results have shown that the surgical glue can effectively immobilize the seeds. Evaluation of the radiation dose distribution revealed that the non-immobilized seed movement would change the planned isodose distribution considerably; while by using surgical glue method to immobilize the seeds, the changes were negligible.

Conclusions

Prostate brachytherapy seed immobilization is necessary and three alternative mechanisms are promising for addressing this issue. Experiments for exploring the efficacy of the other two proposed methods are ongoing. Devices compatible with the brachytherapy procedure will be designed in future.

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Authors and Affiliations

  1. Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA

    K. Yan, T. Podder, I. Buzurovic, Y. Hu, A. Dicker, R. Valicenti & Y. Yu

  2. Departments of Urology and Surgery, University of Rochester, Rochester, NY, USA

    E. Messing

  3. Departments of Imaging Science and Surgery, University of Rochester, Rochester, NY, USA

    D. Rubens

  4. Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, USA

    N. Sarkar

  5. School of Mechanical and Aerospace Engineering, Nangyang Technical University, Singapore, Singapore

    W. Ng

Authors
  1. K. Yan
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  2. T. Podder
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  3. I. Buzurovic
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  4. Y. Hu
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  5. E. Messing
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  6. D. Rubens
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  7. A. Dicker
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  8. R. Valicenti
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  9. N. Sarkar
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  10. W. Ng
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  11. Y. Yu
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Corresponding author

Correspondence to K. Yan.

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Yan, K., Podder, T., Buzurovic, I. et al. Radioactive seed immobilization techniques for interstitial brachytherapy. Int J CARS 3, 165–171 (2008). https://doi.org/10.1007/s11548-008-0156-2

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  • DOI: https://doi.org/10.1007/s11548-008-0156-2

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