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1H- and 31P-myocardial magnetic resonance spectroscopy in non-obstructive hypertrophic cardiomyopathy patients and competitive athletes

  • Cardiac radiology
  • Published:
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Abstract

Purpose

The clinical differentiation between athlete’s heart and mild forms of non-obstructive hypertrophic cardiomyopathy (HCM) is crucial. We hypothesized that differences do exist between the myocardial metabolism of patients with non-obstructive HCM and competitive athletes (CAs). Our aim was to evaluate myocardial metabolism with 31P-MRS and 1H-MRS in HCM patients and CAs.

Materials and methods

After Ethics Committee approval, 15 CAs and 7 HCM patients were prospectively enrolled. They underwent a 1.5-T cardiac MR including electrocardiographically triggered cine images, single-voxel 1H-MRS and multivoxel 31P-MRS. 1H-MRS was performed after imaging using standard coil with the patient in the supine position; thereafter, 31P-MRS was performed using a dedicated coil, in the prone position. Data were reported as median and interquartile range. Mann–Whitney U test was used.

Results

In CAs, left ventricular mass index was 72 (66–83) g/m2, septal thickness 10 (10–11) mm, end diastolic volume index 95 (85–102) ml/m2, end systolic volume index 30 (28–32) ml/m2 and ejection fraction 68% (65–69%); in HCM patients, 81 (76–111) g/m2 (P = 0.052), 18 (15–21) mm (P = 0.003), 73 (58–76) ml/m2 (P = 0.029), 20 (16–34) ml/m2 (P = 0.274) and 68% (55–73%) (P = 1.000), respectively. At 1H-MRS, total lipids were 35 (0–183) arbitrary units (au) for CA and 763 (155–1994) au for HCM patients (P = 0.046). At 31P-MRS, PCr/γATP was 5 (4–6) au for CA and 4 (2–5) au for HCM patients (P = 0.230). Examination time was 20 min for imaging only, 5 min for 1H-MRS and 15 min for 31P-MRS.

Conclusions

We observed a significant increase of myocardial lipids, but a preserved PCr/γATP ratio in the metabolism of HCM patients compared with competitive CAs.

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Acknowledgements

This research received no specific grants from any funding agency in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese, 20097, Milan, Italy

    Francesco Secchi, Giovanni Di Leo & Francesco Sardanelli

  2. Postgraduation School in Radiodiagnostics, Università degli Studi di Milano, Via Festa del Perdono 7, 20100, Milan, Italy

    Marcello Petrini & Riccardo Spairani

  3. Ph.D. Course in Integrated Biomedical Research, Università degli Studi di Milano, Via Mangiagalli 31, 20133, Milan, Italy

    Marco Alì

  4. Cardiology University Department, IRCCS Policlinico San Donato, Università degli Studi di Milano, Via Morandi 30, San Donato Milanese, 20097, Milan, Italy

    Marco Guazzi

  5. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Morandi 30, 20133, Milan, Italy

    Francesco Sardanelli

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  1. Francesco Secchi
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  2. Giovanni Di Leo
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Correspondence to Marco Alì.

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Conflict of interest

F Secchi and G. Di Leo have been sponsored to congresses by Bracco Imaging SpA (Milan, Italy). F. Sardanelli is on the speaker’s bureau for Bracco Imaging SpA (Milan, Italy) and received research grants from Bayer Healthcare (Berlin, Germany).

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Secchi, F., Di Leo, G., Petrini, M. et al. 1H- and 31P-myocardial magnetic resonance spectroscopy in non-obstructive hypertrophic cardiomyopathy patients and competitive athletes. Radiol med 122, 265–272 (2017). https://doi.org/10.1007/s11547-016-0718-2

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