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Diffuse neoplasms of the pleural serosa

Malattie neoplastiche diffuse della sierosa pleurica

  • Chest Radiology / Radiologia Toracica
  • Published:
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Abstract

This study describes the diffuse neoplastic conditions that may affect pleural membranes. These include mesothelioma, the most important and common malignancy of pleural origin, and metastatic involvement by carcinomas, lymphomas and thymomas. On the basis of diagnostic imaging, we identify the distinctive features of pleural involvement by each of these conditions and provide elements enabling accurate differential diagnosis. Finally, we discuss the best diagnostic approach in the case of suspected primary or secondary neoplastic involvement of pleural membranes.

Riassunto

Questa trattazione illustra le patologie neoplastiche diffuse che coinvolgono a vario titolo i foglietti pleurici. Il mesotelioma è la prima neoplasia di origine pleurica per frequenza ed importanza, di seguito analizzeremo gli aspetti peculiari anche dell’interessamento metastatico della pleura da parte di carcinomi, linfomi e timomi. Attraverso le varie diagnostiche radiologiche cercheremo di cogliere gli aspetti peculiari dell’interessamento pleurico da parte di ciascuna di esse e gli spunti utili ad una corretta diagnosi differenziale. Infine analizzeremo quale può essere il corretto iter diagnostico nel sospetto di interessamento neoplastico, primitivo o secondario, dei foglietti pleurici.

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References/Bibliografia

  1. Jeong YJ, Kim S, Kwak SW et al (2008) Neoplastic and non-neoplastic conditions of serosal membrane origin: CT Findings. Radiographics 28:801–818

    Article  PubMed  Google Scholar 

  2. Antunes G, Neville E, Duffy J et al (2003) BTS guidelines for the management of malignant pleural effusions. Thorax 58:ii29–ii38

    Article  PubMed  Google Scholar 

  3. Pisani RJ, Colby TV, Williams DE (1988) Malignant mesothelioma of the pleura. Mayo Clin Proc 63:1234–1244

    Article  PubMed  CAS  Google Scholar 

  4. Rusch VW (2009) Diffuse malignant mesothelioma. In: Shields TW, LoCicero J III, Reed CE, Feins RH (eds) General thoracic surgery. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, pp 847–859

    Google Scholar 

  5. Bortolotto P, Maffessanti M (2000) I processi espansivi della pleura. Radiol Med 99(Suppl 2):207–213

    Google Scholar 

  6. Maffessanti M, Tommasi M, Pellegrini P (1987) Computed tomography of free pleural effusions. Eur J Radiol 7:87–90

    PubMed  CAS  Google Scholar 

  7. Leung AN, Muller NL, Miller RR (1990) CT in differential diagnosis of diffuse pleural disease. AJR Am J Roentgenol 154:487–492

    Article  PubMed  CAS  Google Scholar 

  8. Feragalli B, Storto ML, Bonomo L (2003) Malignant pleural disease. Radiol Med 105:266–288

    PubMed  Google Scholar 

  9. Wang ZJ, Reddy GP, Gotway MB et al (2004) Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics 24:105–119

    Article  PubMed  Google Scholar 

  10. Heelan RT, Rusch VW, Begg CB et al (1999) Staging of malignant pleural mesothelioma: comparison of CT and MR imaging. AJR Am J Roentgenol 172:1039–1047

    Article  PubMed  CAS  Google Scholar 

  11. Patz EF, Shaffer K, Piwnica-Worms DR et al (1992) Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability. AJR Am J Roentgenol 159:961–966

    Article  PubMed  Google Scholar 

  12. Zucali PA, Giaccone G (2006) Biology and management of malignant pleural mesothelioma. Eur J Cancer 42:2706–2714

    Article  PubMed  CAS  Google Scholar 

  13. Giesel FL, Bischoff H, von Tengg-Kobligk H et al (2006) Dynamic contrast-enhanced MRI of malignant pleural mesothelioma: a feasibility study of noninvasive assessment, therapeutic follow-up, and possible predictor of improved outcome. Chest 129:1570–1576

    Article  PubMed  Google Scholar 

  14. Fiore D, Baggio V, Sotti G et al (2006) Imaging before and after multimodal treatment for malignant pleural mesothelioma. Radiol Med 111:355–364

    Article  PubMed  CAS  Google Scholar 

  15. Flores MR, Akhurst T, Gonen M et al (2003) Positron emission tomography defines metastatic disease but not locoregional disease in patients with malignant pleural mesothelioma. J Thorac Cardiovasc Surg 126:11–16

    Article  PubMed  Google Scholar 

  16. Mathis G, Blank W (2008) The chest wall. In: Mathis Gebhard (ed) Chest Sonography. Springer-Verlag, Berlin, Heidelberg, pp 11–22

    Chapter  Google Scholar 

  17. Gorg C, Bert T, Gorg K, Heinzel-Gutenbrunner M (2005) Colour Doppler ultrasound mapping of chest wall lesions. Br J Radiol 78:303–307

    Article  PubMed  CAS  Google Scholar 

  18. Saito T, Kobayashi H, Kitamura S (1988) Ultrasonographic approach to diagnosing chest wall tumors. Chest 94:1271–1275

    Article  PubMed  CAS  Google Scholar 

  19. Bollinger CT, Herth FJ, Mayo PH et al (2009) Clinical chest ultrasound: from ICU to the bronchoscopy suite. Prog Respir Res Basel Karger 37:22–33

    Article  Google Scholar 

  20. Bandi V, Lunn W, Ernst A et al (2008) Ultrasound versus CT in detecting chest wall invasion by tumor: a prospective study. Chest 133:881–886

    Article  PubMed  Google Scholar 

  21. Popić Ramac J, Hebrang A, Ivanovi-Herceg Z et al (2010) The possibilities and limitations of direct digital radiograph, ultrasound and computed tomography in diagnosing malignant pleural mesothelioma. Coll Antropol 34:1263–1271

    PubMed  Google Scholar 

  22. Qureshi NR, Rahman NM, Gleeson FV (2009) Thoracic ultrasound in the diagnosis of malignant pleural effusion. Thorax 64:139–143

    Article  PubMed  CAS  Google Scholar 

  23. Sahn SA (2009) Malignant pleural effusions. In: Shields TW, LoCicero J III, Reed CE, Feins RH (eds) General thoracic surgery. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, pp 875–833

    Google Scholar 

  24. Naidich DP, Webb WR, Muller NL et al (1998) Pleura, chest wall and diaphragm. In: Srichai MB, Naidich DP, Webb WR (eds) Computed tomography and magnetic resonance of the thorax. Lippincott Williams & Wilkins, Philadelphia, pp 657–754

    Google Scholar 

  25. Falaschi F, Battolla L, Mascalchi M et al (1996) Usefulness of MR signal intensity in distinguishing benign from malignant pleural disease. AJR Am J Roentgenol 166:963–968

    Article  PubMed  CAS  Google Scholar 

  26. Gupta NC, Rogers JS, Graeber GM et al (2002) Clinical role of F-18 fluorodeoxyglucose positron emission tomography imaging in patients with lung cancer and suspected malignant pleural effusion. Chest 122:1918–1924

    Article  PubMed  CAS  Google Scholar 

  27. Bonomo L, Feragalli B, Sacco R et al (2000) Malignant pleural disease. Eur J Radiol 34:98–118

    Article  PubMed  CAS  Google Scholar 

  28. Aquino SL, Chen MYM, Kuo WT, Chilles C (1999) The CT appearance of pleural and extrapleural disease in lymphoma. Clin Radiol 54:647–650

    Article  PubMed  CAS  Google Scholar 

  29. Webb WR (2006) Mediastino: masse mediastiniche. In: Webb WR, Higgins CB (eds) Imaging del torace. Verduci Editore, Roma, pp 214–217

    Google Scholar 

  30. Maher MM, Shepard JO (2005) Imaging of thymoma. Semin Thorac Cardiovasc Surg 17:12–19

    Article  PubMed  Google Scholar 

  31. Rosado-de-Christenson ML, Strollo DC, Marom EM (2008) Imaging of thymic epithelial neoplasms. Hematol Oncol Clin N Am 22:409–431

    Article  Google Scholar 

  32. Maskell NA, Butland RJA (2003) BTS guidelines for the investigation of a unilateral pleural effusion in adults. Thorax 58:ii8–ii17

    PubMed  Google Scholar 

  33. Scatarige JC, Fishman EK, Zerhouni EA, Siegelman SS (1985) Transdiaphragmatic extension on invasive thymoma. AJR 144(1):31–35

    Article  PubMed  CAS  Google Scholar 

  34. Adams RF, Gleeson FV (2001) Percutaneous image-guided cutting-needle biopsy of the pleura in the presence of a suspected malignant effusion. Radiology 219:510–514

    PubMed  CAS  Google Scholar 

  35. Benamore RE, Scott K, Richards CJ et al (2006) Image-guided pleural biopsy: diagnostic yield and complications. Clin Radiol 61:700–705

    Article  PubMed  CAS  Google Scholar 

  36. Rusch VW (1995) The International Mesothelioma Interest Group. A proposed new international TNM staging system for malignant pleural mesothelioma. Chest 108:1122–1128

    Article  PubMed  CAS  Google Scholar 

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Correspondence to L. Cardinale.

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Cardinale, L., Ardissone, F., Asteggiano, F. et al. Diffuse neoplasms of the pleural serosa. Radiol med 118, 366–378 (2013). https://doi.org/10.1007/s11547-012-0877-8

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  • DOI: https://doi.org/10.1007/s11547-012-0877-8

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