Abstract
Extinction of an epidemic or a species is a rare event that occurs due to a large, rare stochastic fluctuation. Although the extinction process is dynamically unstable, it follows an optimal path that maximizes the probability of extinction. We show that the optimal path is also directly related to the finite-time Lyapunov exponents of the underlying dynamical system in that the optimal path displays maximum sensitivity to initial conditions. We consider several stochastic epidemic models, and examine the extinction process in a dynamical systems framework. Using the dynamics of the finite-time Lyapunov exponents as a constructive tool, we demonstrate that the dynamical systems viewpoint of extinction evolves naturally toward the optimal path.
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Allen, L. J. S. & Burgin, A. M. (2000). Comparison of deterministic and stochastic SIS and SIR models in discrete time. Math. Biosci., 163, 1–33.
Alonso, D., McKane, A. J., & Pascual, M. (2006). Stochastic amplification in epidemics. J. R. Soc. Interface, 4, 575–582.
Andersson, H. & Britton, T. (2000). Stochastic epidemic models and their statistical analysis. Berlin: Springer.
Anderson, R. M. & May, R. M. (1991). Infectious diseases of humans. Oxford: Oxford University Press.
Assaf, M., Kamenev, A., & Meerson, B. (2008). Population extinction in a time-modulated environment. Phys. Rev. E, 78, 041123.
Aylward, B., Hennessey, K. A., Zagaria, N., Olivé, J.-M., & Cochi, S. (2000). When is a disease eradicable? 100 years of lessons learned. Am. J. Public Heal., 90, 1515–1520.
Azaele, S., Pigolotti, S., Banavar, J. R., & Maritan, A. (2006). Dynamical evolution of ecosystems. Nature, 444, 926–928.
Banavar, J. R. & Maritan, A. (2009). Ecology: towards a theory of biodiversity. Nature, 460, 334–335.
Bartlett, M. S. (1949). Some evolutionary stochastic processes. J. R. Stat. Soc. B Met., 11, 211–229.
Bartlett, M. S. (1957). Measles periodicity and community size. J. R. Stat. Soc. Ser. A–G, 120, 48–70.
Bartlett, M. S. (1960). The critical community size for measles in the United States. J. R. Stat. Soc. Ser. A–G, 123, 37–44.
Bartlett, M. S. (1961). Stochastic population models in ecology and epidemiology. New York: Wiley.
Branicki, M. & Wiggins, S. (2010). Finite-time Lagrangian transport analysis: stable and unstable manifolds of hyperbolic trajectories and finite-time Lyapunov exponents. Nonlinear Process. Geophys., 17(1), 1–36.
Breman, J. G. & Arita, I. (1980). The confirmation and maintenance of smallpox eradication. New Engl. J. Med., 303, 1263–1273.
Choisy, M., Guégan, J.-F., & Rohani, P. (2007). Mathematical modeling of infectious disease dynamics. In M. Tibayrenc (Ed.), Encyclopedia of infectious diseases: modern methodologies (pp. 379–404). New York: Wiley.
Conlan, A. J. K. & Grenfell, B. T. (2007). Seasonality and the persistence and invasion of measles. Proc. R. Soc. B—Biol. Sci., 274, 1133–1141.
de Castro, F. & Bolker, B. (2005). Mechanisms of disease-induced extinction. Ecol. Lett., 8, 117–126.
Doering, C. R., Sargsyan, K. V., & Sander, L. M. (2005). Extinction times for birth-death processes: Exact results, continuum asymptotics, and the failure of the Fokker–Planck approximation. Multiscale Model. Simul., 3(2), 283–299.
Doering, C. R., Sargsyan, K. V., Sander, L. M., & Vanden-Eijnden, E. (2007). Asymptotics of rare events in birth-death processes bypassing the exact solutions. J. Phys.: Condens. Matter, 19, 065145.
Dykman, M. I. (1990). Large fluctuations and fluctuational transitions in systems driven by coloured Gaussian noise: a high-frequency noise. Phys. Rev. A, 42, 2020–2029.
Dykman, M. I., Mori, E., Ross, J., & Hunt, P. M. (1994). Large fluctuations and optimal paths in chemical-kinetics. J. Chem. Phys., 100(8), 5735–5750.
Dykman, M. I., Schwartz, I. B., & Landsman, A. S. (2008). Disease extinction in the presence of random vaccination. Phys. Rev. Lett., 101, 078101.
Elgart, V. & Kamenev, A. (2004). Rare event statistics in reaction-diffusion systems. Phys. Rev. E, 70, 041106.
Gang, H. (1987). Stationary solution of master equations in the large-system-size limit. Phys. Rev. A, 36(12), 5782–5790.
Gardiner, C. W. (2004). Handbook of stochastic methods for physics, chemistry and the natural sciences. Berlin: Springer.
Gaveau, B., Moreau, M., & Toth, J. (1996). Decay of the metastable state in a chemical system: different predictions between discrete and continuous models. Lett. Math. Phys., 37, 285–292.
Grassly, N. C., Fraser, C., & Garnett, G. P. (2005). Host immunity and synchronized epidemics of syphilis across the United States. Nature, 433, 417–421.
Guckenheimer, J. & Holmes, P. (1986). Nonlinear oscillations, dynamical systems, and bifurcations of vector fields. Berlin: Springer.
Haller, G. (2000). Finding finite-time invariant manifolds in two-dimensional velocity fields. Chaos, 10(1), 99–108.
Haller, G. (2001). Distinguished material surfaces and coherent structures in three-dimensional fluid flows. Physica D, 149, 248–277.
Haller, G. (2002). Lagrangian coherent structures from approximate velocity data. Phys. Fluids, 14(6), 1851–1861.
Kamenev, A. & Meerson, B. (2008). Extinction of an infectious disease: a large fluctuation in a nonequilibrium system. Phys. Rev. E, 77, 061107.
Kamenev, A., Meerson, B., & Shklovskii, B. (2008). How colored environmental noise affects population extinction. Phys. Rev. Lett., 101(26), 268103.
Keeling, M. J. & Grenfell, B. T. (1997). Disease extinction and community size: modeling the persistence of measles. Science, 275, 65–67.
Kubo, R. (1963). Stochastic Liouville equations. J. Math. Phys., 4, 174–183.
Kubo, R., Matsuo, K., & Kitahara, K. (1973). Fluctuation and relaxation of macrovariables. J. Stat. Phys., 9(1), 51–96.
Lekien, F., Shadden, S. C., & Marsden, J. E. (2007). Lagrangian coherent structures in n-dimensional systems. J. Math. Phys., 48, 065404.
Lloyd, A. L., Zhang, J., & Root, A. M. (2007). Stochasticity and heterogeneity in host-vector models. J. R. Soc. Interface, 4, 851–863.
Melbourne, B. A. & Hastings, A. (2008). Extinction risk depends strongly on factors contributing to stochasticity. Nature, 454, 100–103.
Minayev, P. & Ferguson, N. (2009). Incorporating demographic stochasticity into multi-strain epidemic models: application to influenza A. J. R. Soc. Interface, 6, 989–996.
Nåsell, I. (2001). Extinction and quasi-stationarity in the Verhulst logistic model. J. Theor. Biol., 211, 11–27.
Pierrehumbert, R. T. (1991). Large-scale horizontal mixing in planetary atmospheres. Phys. Fluids A, 3, 1250–1260.
Pierrehumbert, R. T. & Yang, H. (1993). Global chaotic mixing on isentropic surfaces. J. Atmos. Sci., 50, 2462–2480.
Schwartz, I. B., Billings, L., Dykman, M., & Landsman, A. (2009). Predicting extinction rates in stochastic epidemic models. J. Stat. Mech.—Theory E, P01005.
Schwartz, I. B., Forgoston, E., Bianco, S., & Shaw, L. B. (2010). Converging towards the optimal path to extinction. Submitted.
Shadden, S. C., Lekien, F., & Marsden, J. E. (2005). Definition and properties of Lagrangian coherent structures from finite-time Lyapunov exponents in two-dimensional aperiodic flows. Physica D, 212, 271–304.
Shaw, L. B. & Schwartz, I. B. (2008). Fluctuating epidemics on adaptive networks. Phys. Rev. E, 77, 066101.
Shaw, L. B. & Schwartz, I. B. (2010). Enhanced vaccine control of epidemics in adaptive networks. Phys. Rev. E. In press.
Shaw, L. B., Billings, L., & Schwartz, I. B. (2007). Using dimension reduction to improve outbreak predictability of multistrain diseases. J. Math. Biol., 55, 1–19.
Stone, L., Olinky, R., & Huppert, A. (2007). Seasonal dynamics of recurrent epidemics. Nature, 446, 533–536.
Tretiakov, O. A., Gramespacher, T., & Matveev, K. A. (2003). Lifetime of metastable states in resonant tunneling structures. Phys. Rev. B, 67(7), 073303.
van Kampen, N. G. (2007). Stochastic processes in physics and chemistry. Amsterdam: Elsevier.
Wentzell, A. (1976). Rough limit theorems on large deviations for Markov stochastic processes, I. Theor. Probab. Appl., 21, 227–242.
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Forgoston, E., Bianco, S., Shaw, L.B. et al. Maximal Sensitive Dependence and the Optimal Path to Epidemic Extinction. Bull Math Biol 73, 495–514 (2011). https://doi.org/10.1007/s11538-010-9537-0
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DOI: https://doi.org/10.1007/s11538-010-9537-0