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Epigenetics: major regulators of embryonic neurogenesis

  • Review
  • Life & Medical Sciences
  • Published:
Science Bulletin

Abstract

Mammalian cortical development is a dynamically and strictly regulated process orchestrated by extracellular signals and intracellular mechanisms. Recent studies show that epigenetic regulation serves as, at least in part, interfaces between genes and the environment, and also provides insight into the molecular and cellular bases of early embryonic cortical development. It is becoming increasingly clear that epigenetic regulation of cortical development occurs at multiple levels and that comprehensive knowledge of this complex regulatory landscape is essential to delineating embryonic neurogenesis.

摘要

哺乳动物大脑皮层发育是一个受细胞内、外信号途径严格调控的过程,经历了一系列重要的生物学事件,最终形成复杂而精细的神经系统。在结构与功能水平上,大脑皮层早期发育主要包括神经干细胞的自我更新、分化、迁移及最终形成正确的突触联系。表观遗传调控主要包括DNA、组蛋白、RNA的共价修饰和染色质重塑、非编码RNA的调控作用等方面。目前,越来越多的研究表明表观遗传调控在早期大脑皮层发育过程中发挥重要作用。此外,大脑皮层发育异常将导致各种神经系统疾病。该文简单总结了参与大脑皮层发育的多种表观遗传调控机制,以期促进对大脑皮层发育的认识。

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Acknowledgments

This work was supported by the Chinese Ministry of Science and Technology (2015CB964501 and 2014CB964903), the National Natural Science Foundation of China (31371477), and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020301).

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Authors and Affiliations

  1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China

    Tianjin Shen, Fen Ji & Jianwei Jiao

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Tianjin Shen

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  1. Tianjin Shen
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  2. Fen Ji
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  3. Jianwei Jiao
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Correspondence to Jianwei Jiao.

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SPECIAL TOPIC: Stem Cell, Basis and Application

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Shen, T., Ji, F. & Jiao, J. Epigenetics: major regulators of embryonic neurogenesis. Sci. Bull. 60, 1734–1743 (2015). https://doi.org/10.1007/s11434-015-0871-3

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