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The cancer genomics and global cancer genome collaboration

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  • Life & Medical Sciences
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Science Bulletin

Abstract

All cancers arise as a result of abnormalities occurring in the DNA sequence of cancer cells, and we are now stepping into an era in which it is feasible to obtain the complete DNA sequence of large cohorts of cancer patients. The International Cancer Genome Consortium (ICGC) launched in 2007 is devoted to coordinate large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes and systematic studies of more than 25,000 cancer genomes. Several participant groups have summarized and published their data for various cancers. As the active members of ICGC, Chinese cancer genome investigators have contributed research for 13 tumor types and released some research articles about esophageal, liver, bladder, and kidney cancers. As genetic alterations in thousands of tumors have now been catalogued, the pan-cancer analysis has become the most significant role of ICGC at present. The ICGC research network will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define molecular subtypes for clinical implication, and enable the development of individual therapeutics for human cancers.

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Acknowledgment

This work was supported by the National Natural Science Foundation of China (81402300). We thank Scott Edmunds for revising this manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, 100021, China

    Xueda Hu & Jie He

  2. BGI-Shenzhen, Shenzhen, 518083, China

    Huanming Yang

  3. James D. Watson Institute of Genome Sciences, Hangzhou, 310029, China

    Huanming Yang

  4. Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, 100142, China

    Youyong Lu

Authors
  1. Xueda Hu
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  2. Huanming Yang
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  3. Jie He
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  4. Youyong Lu
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Corresponding author

Correspondence to Youyong Lu.

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Hu, X., Yang, H., He, J. et al. The cancer genomics and global cancer genome collaboration. Sci. Bull. 60, 65–70 (2015). https://doi.org/10.1007/s11434-014-0692-9

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  • DOI: https://doi.org/10.1007/s11434-014-0692-9

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