Skip to main content
SpringerLink
Log in

Interaction of multi-walled carbon nanotubes and zinc ions enhances cytotoxicity of zinc ions

  • Articles
  • Published:
Science China Chemistry Aims and scope Submit manuscript

Abstract

More and more nanomaterials enter the environment along with their production, application and deposal. They may alter the biological effect of pollutants already existing in the real environment by different interactions. Therefore efforts should also be paid to investigate the combined toxicity of nanomaterials and pollutants. Herein, we studied the combined toxicity of oxidized multi-walled carbon nanotubes (O-MWCNTs) and zinc ions on cells. It is found that cytotoxicity of the combined O-MWCNTs and zinc ions elevates significantly, compared with O-MWCNTs or zinc ions alone. This result comes from the assays of cell morphology, cell viability and proliferation, cell membrane integrity, mitochondrial membrane potential and cell apoptosis. Mechanism studies indicate that O-MWCNTs absorb zinc ions and form slight aggregation. These enhance remarkably the cellular uptake of O-MWCNTs, and thus induce the death of cells by bringing in more zinc ions into cells. Our study indicates that the existence of nanomaterials could change the bioconsequence of other pollutants and emphasizes the importance of the combined toxicity research in the presence of nanomaterials.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nowack B, David RM, Fissan H, Morris H, Shatkin JA, Stintz M, Zepp R, Brouwer D. Environ Int, 2013, 59: 1–11

    Article  CAS  Google Scholar 

  2. Wang H, Du LJ, Song ZM, Chen XX. Nanomedicine, 2013, 8: 2007–2025

    Article  CAS  Google Scholar 

  3. Gottschalk F, Sun TY, Nowack B. Environ Pollut, 2013, 181: 287–300

    Article  CAS  Google Scholar 

  4. Holden PA, Klaessig F, Turco RF, Priester JH, Rico CM, Avila-Arias H, Mortimer M, Pacpaco K, Gardea-Torresdey JL. Environ Sci Technol, 2014, 48: 10541–10551

    Article  CAS  Google Scholar 

  5. Viana M, Rivas I, Querol X, Alastuey A, Sunyer J, Alvarez-Pedrerol M, Bouso L, Sioutas C. Atmos Chem Phys, 2014, 14: 4459–4472

    Article  CAS  Google Scholar 

  6. Burkart W, Jung T. Mutat Res-Rev Mutat Res, 1998, 411: 119–128

    Article  Google Scholar 

  7. Silins I, Hogberg J. Int J Environ Res Public Health, 2011, 8: 629–647

    Article  Google Scholar 

  8. Kim KT, Klaine SJ, Lin S, Ke PC, Kim SD. Environ Toxicol Chem, 2010, 29: 122–126

    Article  CAS  Google Scholar 

  9. Caballero-Diaz E, Guzman-Ruiz R, Malagon MM, Simonet BM, Valcarcel M. J Hazard Mater, 2014, 275: 107–115

    Article  CAS  Google Scholar 

  10. Song M, Wang F, Zeng L, Yin J, Wang H, Jiang G. Environ Sci Technol, 2014, 48: 13978–13984

    Article  CAS  Google Scholar 

  11. Yu YL, Zhuang YT, Song XY, Wang JH. Chem Eng J, 2015, 280: 58–65

    Article  CAS  Google Scholar 

  12. Wang YW, Cao A, Jiang Y, Zhang X, Liu JH, Liu Y, Wang H. ACS Appl Mater Interf, 2014, 6: 2791–2798

    Article  CAS  Google Scholar 

  13. Zhang X, Liu M, Zhang X, Deng F, Zhou C, Hui J, Liu W, Wei Y. Toxicol Res, 2015, 4: 160–168

    Article  Google Scholar 

  14. de Volder MFL, Tawfick SH, Baughman RH, Hart AJ. Science, 2013, 339: 535–539

    Article  Google Scholar 

  15. Liu P, Qi W, Du YF, Li Z, Wang J, Bi JJ, Wu WS. Sci China Chem, 2014, 57: 1483–1490

    Article  CAS  Google Scholar 

  16. Li YD. Sci China Chem, 2014, 57: 1184

    Article  CAS  Google Scholar 

  17. Lin G, Liang X, Liu Z, Xie J, Chen B, Zhang H. Sci China Chem, 2015, 58: 47–59

    Article  CAS  Google Scholar 

  18. van Sprang PA, Verdonck FAM, van Assche F, Regoli L, de Schamphelaere KAC. Sci Total Environ, 2009, 407: 5373–5391

    Article  Google Scholar 

  19. Yang ST, Wang H, Wang Y, Wang Y, Nie H, Liu Y. Chemosphere, 2011, 82: 621–626

    Article  CAS  Google Scholar 

  20. Ren X, Chen C, Nagatsu M, Wang X. Chem Eng J, 2011, 170: 395–410

    Article  CAS  Google Scholar 

  21. Wong BS, Yoong SL, Jagusiak A, Panczyk T, Ho HK, Ang WH, Pastorin G. Adv Drug Deliver Rev, 2013, 65: 1964–2015

    Article  CAS  Google Scholar 

  22. Kumar R, Khan MA, Haq N. Crit Rev Environ Sci Technol, 2014, 44: 1000–1035

    Article  CAS  Google Scholar 

  23. Coccini T, Roda E, Sarigiannis DA, Mustarelli P, Quartarone E, Profumo A, Manzo L. Toxicology, 2010, 269: 41–53

    Article  CAS  Google Scholar 

  24. Ma X, Zhang LH, Wang LR, Xue X, Sun JH, Wu Y, Zou G, Wu X, Wang PC, Wamer WG, Yin JJ, Zheng K, Liang XJ. ACS Nano, 2012, 6: 10486–10496

    Article  CAS  Google Scholar 

  25. Yuan Y, Chen Y, Liu JH, Wang H, Liu Y. Diam Relat Mater, 2009, 18: 95–100

    Article  CAS  Google Scholar 

  26. Guo F, Ma N, Horibe Y, Kawanishi S, Murata M, Hiraku Y. Toxicol Appl Pharm, 2012, 260: 183–192

    Article  CAS  Google Scholar 

  27. Wang J, Sun R, Zhang N, Nie H, Liu JH, Wang J, Wang H, Liu Y. Carbon, 2009, 47: 1752–1760

    Article  CAS  Google Scholar 

  28. Zhang X, Hu W, Li J, Tao L, Wei Y. Toxicol Res, 2012, 1: 62–68

    Article  CAS  Google Scholar 

  29. Zhao F, Zhang Y, Liu Y, Chang X, Chen C, Zhao Y. Small, 2011, 7: 1322–1337

    Article  CAS  Google Scholar 

  30. He X, Kuang Y, Li Y, Zhang H, Ma Y, Bai W, Zhang Z, Wu Z, Zhao Y, Chai Z. Nanotoxicology, 2012, 6: 233–240

    Article  CAS  Google Scholar 

  31. Pagnout C, Jomini S, Dadhwal M, Caillet C, Thomas F, Bauda P. Colloid Surf B, 2012, 92: 315–321

    Article  CAS  Google Scholar 

  32. Shi Y, Zhang JH, Jiang M, Zhu LH, Tan HQ, Lu B. Environ Mol Mutagen, 2010, 51: 192–204

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, China

    Lin Wang, Zheng-Mei Song, Yi-Xin Yang, Aoneng Cao, Yuanfang Liu & Haifang Wang

  2. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China

    Jia-Hui Liu

  3. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China

    Yuanfang Liu

Authors
  1. Lin Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jia-Hui Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zheng-Mei Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yi-Xin Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Aoneng Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yuanfang Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Haifang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Haifang Wang.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, L., Liu, JH., Song, ZM. et al. Interaction of multi-walled carbon nanotubes and zinc ions enhances cytotoxicity of zinc ions. Sci. China Chem. 59, 910–917 (2016). https://doi.org/10.1007/s11426-016-5591-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11426-016-5591-2

Keywords

Search

Navigation