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Incorporation of azide sugar analogue decreases tumorigenic potential of breast cancer cells by reducing cancer stem cell population

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  • Special Topic The Frontiers of Chemical Biology and Synthesis
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Abstract

The azido sugar, GalNAz, was successfully used for imaging and perturbing protein glycosylation in triple-negative breast cancer cell line, MDA-MB-231. After the incorporation of GalNAz in the triple-negative breast cancer cell line, the tumorigenicity of these cells was decreased. Results from gene analysis and drug treatment suggest that the tumorigenicity decrease may be attributed to the reduction of cancer stem cell population. Possible mechanisms of GalNAz induced cancer stem cells (CSCs) proportion change are discussed.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of South Carolina, Columbia, 29208, USA

    XinRui Duan, Lim Andrew Lee & Qian Wang

  2. Division of Mathematics and Science, University of South Carolina Salkehatchie, Walterboro, SC, 29488, USA

    Li Cai

  3. Department of Biological Sciences, University of South Carolina, Columbia, 29208, USA

    HeXin Chen

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  1. XinRui Duan
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  2. Li Cai
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  3. Lim Andrew Lee
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  5. Qian Wang
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Correspondence to Li Cai or Qian Wang.

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Duan, X., Cai, L., Lee, L.A. et al. Incorporation of azide sugar analogue decreases tumorigenic potential of breast cancer cells by reducing cancer stem cell population. Sci. China Chem. 56, 279–285 (2013). https://doi.org/10.1007/s11426-012-4806-4

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  • DOI: https://doi.org/10.1007/s11426-012-4806-4

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