Articles Special Topic The Frontiers of Chemical Biology and Synthesis

Science China Chemistry

, Volume 56, Issue 3, pp 279-285

Incorporation of azide sugar analogue decreases tumorigenic potential of breast cancer cells by reducing cancer stem cell population

  • XinRui DuanAffiliated withDepartment of Chemistry and Biochemistry, University of South Carolina
  • , Li CaiAffiliated withDivision of Mathematics and Science, University of South Carolina Salkehatchie Email author 
  • , Lim Andrew LeeAffiliated withDepartment of Chemistry and Biochemistry, University of South Carolina
  • , HeXin ChenAffiliated withDepartment of Biological Sciences, University of South Carolina
  • , Qian WangAffiliated withDepartment of Chemistry and Biochemistry, University of South Carolina Email author 

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Abstract

The azido sugar, GalNAz, was successfully used for imaging and perturbing protein glycosylation in triple-negative breast cancer cell line, MDA-MB-231. After the incorporation of GalNAz in the triple-negative breast cancer cell line, the tumorigenicity of these cells was decreased. Results from gene analysis and drug treatment suggest that the tumorigenicity decrease may be attributed to the reduction of cancer stem cell population. Possible mechanisms of GalNAz induced cancer stem cells (CSCs) proportion change are discussed.

Keywords

breast cancer glycosylation cell imaging cancer stem cell SPAAC reaction azidoglycan