Science China Chemistry

, Volume 56, Issue 3, pp 279–285

Incorporation of azide sugar analogue decreases tumorigenic potential of breast cancer cells by reducing cancer stem cell population

Articles Special Topic The Frontiers of Chemical Biology and Synthesis

DOI: 10.1007/s11426-012-4806-4

Cite this article as:
Duan, X., Cai, L., Lee, L.A. et al. Sci. China Chem. (2013) 56: 279. doi:10.1007/s11426-012-4806-4
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Abstract

The azido sugar, GalNAz, was successfully used for imaging and perturbing protein glycosylation in triple-negative breast cancer cell line, MDA-MB-231. After the incorporation of GalNAz in the triple-negative breast cancer cell line, the tumorigenicity of these cells was decreased. Results from gene analysis and drug treatment suggest that the tumorigenicity decrease may be attributed to the reduction of cancer stem cell population. Possible mechanisms of GalNAz induced cancer stem cells (CSCs) proportion change are discussed.

Keywords

breast cancerglycosylationcell imagingcancer stem cellSPAAC reactionazidoglycan

Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of South CarolinaColumbiaUSA
  2. 2.Division of Mathematics and ScienceUniversity of South Carolina SalkehatchieWalterboroUSA
  3. 3.Department of Biological SciencesUniversity of South CarolinaColumbiaUSA