Abstract
Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1–3 were elucidated by spectral data to have a cadinane skeleton with an aromatic ring. Of the eight compounds isolated, compound 4, identified as mansonone I, was found to be active against TOP, having an IC50 of 1.2 μM.
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Acknowledgements
We would like to thank Professor Jeremy Nathans (John Hopkins University School of Medicine) for the STF/293 cells and Professor Ronald T. Moon (University of Washington) for the Super FOPFlash plasmid.
Funding
This study was supported by KAKENHI Grant Numbers 18H02582 and 17H03992 from the Japan Society for the Promotion of Science (JSPS).
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Sato, T., Arai, M.A., Yixizhuoma et al. Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity. J Nat Med 74, 476–481 (2020). https://doi.org/10.1007/s11418-019-01380-x
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DOI: https://doi.org/10.1007/s11418-019-01380-x