Abstract
Aconite root has high toxicity caused by diester alkaloids, thus it was necessary to define the limiting value of diester alkaloids used in medicine formulation. To give the quality of “Processed Aconite Root” and “Powdered Processed Aconite Root” in the Japanese Pharmacopoeia (14th edn, supplement II), we established the official specification and evaluation methods of standard substances. High qualitative grade diester alkaloids, aconitine, hypaconitine, jesaconitine and mesaconitine, which were useful to evaluate the purity of processed aconite root and powdered processed aconite root, were prepared and evaluated for their stability. We studied the physicochemical specification and evaluation methods of these alkaloids. In addition, an “Aconitum diester alkaloids standard solution for purity”, which was used for the purity test, was prepared, and we also studied its physicochemical specification and evaluation methods. In addition, to evaluate the quality of processed aconite root and powdered processed aconite root, a TLC identification test was established. A monoester alkaloid of benzoylmesaconine hydrochloride was used as the reference standard in the latter test, and we also investigated its physicochemical specification and evaluation methods.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Yomura K, Kikuchi Y, Ishimatsu M, Niitsu K, Sakakibara I, Yamamoto T, Higuchi M, Sasaki H, Okada M, Yamamoto K, Kondo S, Sekita S, Satake M (2001) Quality evaluation of natural compounds isolated from crude drugs (part 1) Aristolochic acid I. Iyakuhin Kenkyu 32:717–724
Nakamura Y, Yomura K, Kikuchi Y, Ishimatsu M, Niitsu K, Sakakibara I, Higuchi M, Amagaya S, Aburada M, Okada M, Sekita S, Satake M (2003) Quality evaluation of natural compounds isolated from crude drugs (part 2) Aristolochic acid II. Iyakuhin Kenkyu 34:485–492
Japanese Pharmacopoeia (2005) 14th edn, supplement II. Society of Japanese Pharmacopoeia
Hikino H, Ito T, Yamada C, Sato H, Konno C, Ohizumi Y (1979) Analgesic principles of Aconitum roots. J Pharm Dyn 2:78–83
Hikino H (1981) Physiological actions of Aconitum. Gendai Toyo Igaku 2:44–49
Hikino H (1988) Analysis of aconitinealkaloids in aconite roots(part 1). Pharm Tech Jpn 4:551–555
The Japanese Pharmacopoeia technical information (2001) Society of Japanese Pharmacopoeia. JIHO Inc
Handbook of natural products data, vol 1. Diterpenoid and steroidal alkaloids (1990) Elsevier, Amsterdam
Pelletier SW, Z Djarmati (1976) Carbon-13 nuclear magnetic resonance: aconitine-type diterpenoid alkaloids from Aconitum and Delphinium species. J Am Chem Soc 98:2626–2636
Takayama H, Tokita A, Ito M, Sasaki S, Kurosaki F, Okamoto T (1982) On the alkaloids of Aconitum yesoense NAKAI. Yakugaku Zasshi 102:245–257
Takayama H, Hasegawa S, Sakai S, Haginiwa J, Okamoto T (1982) On the alkaloids of Aconitum japonicum THUNB collected at Mt. Mineoka (Chiba pref.): structure elucidation and partial synthesis of a new alkaloid, 15-α-hydroxyneoline. Yakugaku Zasshi 102:525–532
Mori T, Bando H, Kanaiwa Y, Wada K, Amiya T (1983) Studies on the constituents of aconitum species. II. Structure of deoxyjesaconitine. Chem Pharm Bull 31:2884–2886
Sakai S, Yamamoto I, Hotoda K, Yamagichi K, Aimi N, Yamanaka E, Haginiwa J, Okamoto T (1984) On the alkaloids of Aconitum ibukiense NAKAI collected at Mt. Ryosen (Shiga pref.). Yakugaku Zasshi 104:222–237
Acknowledgements
We are most grateful to the JP members concerned for supporting this work.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nakamura, Y., Yomura, K., Kammoto, T. et al. Physicochemical quality evaluation of natural compounds isolated from crude drugs. J Nat Med 60, 285–294 (2006). https://doi.org/10.1007/s11418-006-0005-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11418-006-0005-y