Abstract
The purpose of this study is to examine whether benzyl alcohol affects N-methyl-D-aspartate (NMDA) receptor in cortical cells. Benzyl alcohol (0.5–2 mM) inhibited NMDA-induced cytotoxicity. The protective effect of benzyl alcohol on NMDA-induced toxicity disappeared by washing cells with buffer to remove benzyl alcohol. Benzyl alcohol reduced NMDA receptor-mediated calcium accumulation, indicating that benzyl alcohol inhibits NMDA receptor activity.
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Acknowledgment
This study was supported in part by a special in-house research grant from Hokuriku University.
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Takadera, T., Ohyashiki, T. Benzyl alcohol inhibits N-methyl-d-aspartate receptor-mediated neurotoxicity and calcium accumulation in cultured rat cortical neurons. J Biomed Sci 15, 767–770 (2008). https://doi.org/10.1007/s11373-008-9276-5
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DOI: https://doi.org/10.1007/s11373-008-9276-5