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Clinical characteristics of sleep disorders in patients with vestibular migraine

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

To study and analyze the sleep quality and sleep structure of patients with vestibular migraine (VM).

Methods

In this cross-sectional case-control study, the Pittsburgh Sleep Quality Index (PSQI) questionnaire and polysomnography (PSG) were used to compare the clinical characteristics of sleep disorders in 49 patients with VM, 52 patients with migraine, and 54 controls.

Results

The VM, migraine, and control groups did not significantly differ in terms of age or sex. Compared with the migraine and control groups, the VM group had a higher incidence of poor sleep quality (χ2 = 36.618, p < 0.01) and greater severity of poor sleep quality (p < 0.01). Furthermore, the VM group showed reduced sleep efficiency (p < 0.01) and reduced proportions of REM and slow wave (N3) sleep (p ≤ 0.01). Conversely, sleep latency (p = 0.01) and REM latency (p = 0.04) were prolonged, and proportions of light sleep phases (N1, p < 0.05, and N2, p < 0.01) and the micro-arousal index (p = 0.03) were increased. The migraine group had significantly higher apnea hypopnea (AHI) and periodic leg movement (PLMI) indices than the VM group.

Conclusion

We report an effect of VM on sleep structure and an association with migraine. Similar to migraine, VM affects the sleep regulation centers and causes structural sleep disorders.

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Funding

Key Scientific and Technological Research Projects in Henan Province (grant number 182102310586) and the Funding Scheme for Key Scientific Research Projects of Henan Higher Education Institutions (grant number 19A320039) provided funding for this study. The funding agencies had no role in the study design, collection, analysis, or interpretation of data, writing of the report, or decision to submit the article for publication.

Author information

Authors and Affiliations

  1. The Second Affiliated Hospital of Zhengzhou University, No. 2 Jingba Road, Jinshui District, Zhengzhou City, 450000, Henan Province, China

    Jun Wu, Chunling Liu, Haitao Yu, Hui Li, Yanlu Jia, Lili Chen & Xiaonan Li

  2. The Affiliated Hospital of Binzhou Medical University, Yantai, China

    Defu Zhang

Authors
  1. Jun Wu
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  2. Chunling Liu
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  3. Haitao Yu
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  4. Hui Li
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  5. Yanlu Jia
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  6. Defu Zhang
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  7. Lili Chen
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  8. Xiaonan Li
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Wu Jun, Li Hui, and Yu Haitao. The first draft of the manuscript was written by Wu Jun and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Chunling Liu.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The procedures described here have been approved by the Ethics Committee of the Second Affiliated Hospital of Zhengzhou University and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Wu, J., Liu, C., Yu, H. et al. Clinical characteristics of sleep disorders in patients with vestibular migraine. Sleep Breath 24, 1383–1388 (2020). https://doi.org/10.1007/s11325-019-01994-1

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  • DOI: https://doi.org/10.1007/s11325-019-01994-1

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