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Elevated serum concentrations of lipopolysaccharide binding protein might prolong sleep stage one in middle-aged hypertensive males

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

Sleep architecture can be affected by alteration in circulating lipopolysaccaride and cytokines. However, still unknown are the effects of lipopolysaccaride-binding protein (LBP) on sleep architecture. Therefore, potential relationship between alteration in serum LBP concentrations and sleep architecture was analyzed.

Methods

This is a cross-sectional study. Consecutive 54 hypertensive males, aged 30–65 years. and with no obstructive sleep apnea via polysomnography, were recruited. Subjects were divided into two groups via the LBP median as hypertensives with higher and lower serum LBP (n = 27 and n = 27, respectively). Sleep architecture was assessed by polysomnography. Serum LBP, IL-1β, IL-6, and TNF-α were measured by commercial laboratories using sandwich-type enzyme immunoassay kit.

Results

Hypertensive subjects with higher LBP showed significantly higher inflammatory status as assessed by IL-1β (18.85 ± 3.71 vs 16.15 ± 4.00 ng/L, P = 0.009), IL-6 (67.64 ± 11.22 vs 58.94 ± 11.32 ng/L, P = 0.004), and TNF-α (322.27 ± 59.17 vs 283.89 ± 61.87 pg/ml, P = 0.024) than did those with lower LBP. Hypertensives with higher serum LBP also exhibited prolonged N1 % (7.63 ± 3.55 vs 4.98 ± 2.90 %, P = 0.002), the transition from wakefulness to other sleep stages or follows arousal during sleep, than did those with lower LBP. A significant positive correlation was observed between serum LBP concentrations and N1 % (r = 0.378, P = 0.005) via Spearman’s correlation and remained significant even after adjusting for age, apnea-hypopnea index, and body mass index.

Conclusion

Elevation in serum concentrations of LBP might prolong N1 % in this middle-aged hypertensive males, which needs to be confirmed further.

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Acknowledgments

The authors thank all the participants for agreeing to provide all the clinical data and blood samples, and all the staffs of hypertension center for collaborating to accomplish this study.

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Authors and Affiliations

  1. The Center of Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China

    Mulalibieke Heizhati, Nanfang Li, Liang Shao, Xiaoguang Yao, Yingchun Wang, Jing Hong, Ling Zhou, Delian Zhang, Guijuan Chang & Suofeiya Abulikemu

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  1. Mulalibieke Heizhati
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  2. Nanfang Li
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  3. Liang Shao
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  4. Xiaoguang Yao
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  5. Yingchun Wang
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  6. Jing Hong
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  7. Ling Zhou
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  8. Delian Zhang
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  9. Guijuan Chang
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  10. Suofeiya Abulikemu
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Corresponding author

Correspondence to Nanfang Li.

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Funding

Xinjiang China provided financial support in the form of the Natural Science Foundation of Xinjiang (2015211C197). The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

Ethics Committee of the People’s Hospital of Xinjiang Uygur Autonomous Region approved the study protocol. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Heizhati, M., Li, N., Shao, L. et al. Elevated serum concentrations of lipopolysaccharide binding protein might prolong sleep stage one in middle-aged hypertensive males. Sleep Breath 21, 327–332 (2017). https://doi.org/10.1007/s11325-016-1415-z

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  • DOI: https://doi.org/10.1007/s11325-016-1415-z

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