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Relationship of obstructive sleep apnea and cardiometabolic risk factors in elderly patients with abdominal aortic aneurysm

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Abstract

Purpose

This study seeks to determine the risks for obstructive sleep apnea (OSA) and cardiometabolic disease (CMR) in elderly patients with mild-moderate abdominal aortic aneurysms (AAA).

Methods

Three hundred two elderly patients with diagnosed small AAA disease were subjects. CMR was assessed by several biomarkers, with special focus on the Lipid Accumulation Product (LAP) and the Triglyceride-Glucose Index (TyG Index), two validated screening indicators of CMR related to central obesity and insulin resistance, respectively. Analysis of OSA risk was assessed with the Berlin Questionnaire.

Results

The patients (60.6 %) had increased risk of OSA; those at high risk also were at increased (p < 0.05) risk for CMR (15/25 biomarkers).

Conclusions

As a group, elderly AAA patients are at risk for both OSA and cardiometabolic disease. Given that OSA and CMR may both amplify risk for AAA expansion, these patients should be screened for OSA, and when indicated, referred for definitive evaluation and treatment.

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Acknowledgments

This study was funded by the National Heart, Lung, and Blood Institute (Clinicaltrials.gov identifier: NCT00349947). The investigators thank all subjects, volunteers and researchers involved in the study for their contributions.

Conflict of interest

No industry consideration or support was provided to conduct this research, either to the authors or the institutions where the work was performed. None of the authors have any conflicts of interest to report.

Author information

Authors and Affiliations

  1. Center for Clinical Nutrition, Metabolism and Physical Performance, V. Bertani, 34-47900, Rimini, Italy

    Vittorio E. Bianchi

  2. Department of Human Nutrition, Foods & Exercise, Virginia Tech, 338 Wallace Hall, Blacksburg, VA, 24061, USA

    William G. Herbert

  3. VA Palo Health Care System and Stanford University, Cardiology 111C, 3801 Miranda Ave, Palo Alto, CA, 94304, USA

    Jonathan Myers

  4. Department of Health & Exercise Sciences, Wake Forest University, 303Reynolds Gymnasium, Winston-Salem, NC, USA

    Paul M. Ribisl

  5. Miller Scientific Consulting, Inc., 1854 Hendersonville Road, #231, Asheville, NC, 28803, USA

    Larry E. Miller

  6. Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA

    Ronald L. Dalman

Authors
  1. Vittorio E. Bianchi
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  2. William G. Herbert
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  3. Jonathan Myers
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  4. Paul M. Ribisl
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  5. Larry E. Miller
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  6. Ronald L. Dalman
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Corresponding author

Correspondence to Jonathan Myers.

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Bianchi, V.E., Herbert, W.G., Myers, J. et al. Relationship of obstructive sleep apnea and cardiometabolic risk factors in elderly patients with abdominal aortic aneurysm. Sleep Breath 19, 593–598 (2015). https://doi.org/10.1007/s11325-014-1053-2

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  • DOI: https://doi.org/10.1007/s11325-014-1053-2

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