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Effect of a 2 week CPAP treatment on mood states in patients with obstructive sleep apnea: a double-blind trial

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Abstract

Obstructive sleep apnea (OSA) is a common disease with significant medical and psychiatric comorbidities. The literature documenting the effects of continuous positive airway pressure (CPAP) treatment on mood in OSA patients is mixed. We previously observed that 1 week of CPAP treatment did not result in improvements in mood beyond those observed in a group treated with placebo–CPAP. This study examined the effect of a 2 week CPAP treatment on mood in a placebo-controlled design in OSA patients. Fifty patients with untreated sleep apnea were evaluated by polysomnography and completed the Profile of Mood States (POMS) pre-/post-treatment. The patients were randomized for 2 weeks to either therapeutic CPAP or placebo–CPAP (at insufficient pressure). Both the therapeutic CPAP and the placebo–CPAP groups showed significant improvements in POMS total score, tension, fatigue, and confusion. No significant time × treatment effect was observed for either group. We could not show a specific beneficial impact of CPAP treatment on mood in OSA patients.

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Acknowledgments

This research was supported by NIH grants AG08415, HL44915, HL36005, and RR00827.

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Authors and Affiliations

  1. Department of General Internal Medicine, University Hospital Berne, Bern, Switzerland

    Alexander Haensel

  2. Department of Psychiatry, University of California, San Diego, USA

    Alexander Haensel, Wayne A. Bardwell, Sonia Ancoli-Israel & Joel E. Dimsdale

  3. Moores UCSD Cancer Center, La Jolla, USA

    Loki Natarajan, Wayne A. Bardwell, Sonia Ancoli-Israel & Joel E. Dimsdale

  4. Pulmonary and Critical Care Medicine, University of California, San Diego, USA

    Daniel Norman

  5. USCD Psychiatry, 9500 Gilman Drive, La Jolla, CA, USA

    Alexander Haensel

Authors
  1. Alexander Haensel
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  2. Daniel Norman
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  3. Loki Natarajan
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  4. Wayne A. Bardwell
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  5. Sonia Ancoli-Israel
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  6. Joel E. Dimsdale
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Correspondence to Alexander Haensel.

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Haensel, A., Norman, D., Natarajan, L. et al. Effect of a 2 week CPAP treatment on mood states in patients with obstructive sleep apnea: a double-blind trial. Sleep Breath 11, 239–244 (2007). https://doi.org/10.1007/s11325-007-0115-0

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