Abstract
Coxsackievirus B4 is a member of the species Enterovirus B in the Enterovirus genus of the Picornaviridae family. So far, there are only seven complete genome sequences of CVB4 published in GenBank database. In the study, the complete genome analysis of a Coxsackievirus B4 strain A155/YN/CHN/2009 isolated from a child with aseptic meningitis in Yunnan Province was performed. It had 85.1 and 83.3 % nucleotide similarity with prototype strain J.V.B Benschoten in the VP1 region and the complete genome, respectively. Phylogenetic analysis of VP1 region showed that A155/YN/CHN/2009 belongs to Genotype V circulating only in mainland of China. The results of Simplot and Bootscanning analysis implicated that A155 has recombined with other HEV-B viruses.
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N.J. Knowles, T. Hovi, T. Hyypiä, A.M.Q. King, A.M. Lindberg, M.A. Pallansch, A.C. Palmenberg, P. Simmonds, T. Skern, G. Stanway, T. Yamashita, R. Zell, in Virus Taxonomy Ninth Report of the International Committee on Taxonomy of Viruses, ed. by A.M.Q. King, M.J. Adams, E.B. Carstens, E.J. Lefkowitz (Elsevier/Academic Press, London, 2011), p. 855
J.L. Bailly, D. Brosson, C. Archimbaud, M. Chambon, C. Henquell, H. Peigue-Lafeuille, J. Med. Virol. 68, 558 (2002)
G.P. Leonardi, A.J. Greenberg, P. Costello, K. Szabo, Intervirology 36, 53 (1993)
H.J. Kim, B. Kang, S. Hwang, J. Hong, K. Kim, D.S. Cheon, J. Virol. 9, 38 (2012)
J. Richter, D. Koptides, C. Tryfonos, C. Christodoulou, J. Med. Microbiol. 55, 1035 (2006)
A. Kumar, D. Shukla, R. Kumar, M.Z. Idris, U.K. Misra, T.N. Dhole, J. Clin. Microbiol. 50, 3509 (2012)
Z. Tao, H. Wang, Y. Li, G. Liu, A. Xu, X. Lin, L. Song, F. Ji, S. Wang, N. Cui, Y. Song, PLoS One 9, e89766 (2014)
O. Jenkins, J.D. Booth, P.D. Minor, J.W. Almond, J. Gen. Virol. 68, 1835 (1987)
X. Tian, Y. Zhang, S. Gu, Y. Fan, Q. Sun, B. Zhang, S. Yan, W. Xu, X. Ma, W. Wang, PLoS One 9, e90379 (2014)
Who, Polio Laboratory Manual, 4th edn. (World Health Organization, Geneva, 2004)
N. Prim, G. Rodriguez, N. Margall, M. Del Cuerpo, G. Trallero, N. Rabella, J. Med. Virol. 85, 116 (2013)
W.A. Nix, M.S. Oberste, M.A. Pallansch, J. Clin. Microbiol. 44, 2698 (2006)
K. Tamura, G. Stecher, D. Peterson, A. Filipski, S. Kumar, Mol. Biol. Evol. 30, 2725 (2013)
K.S. Lole, R.C. Bollinger, R.S. Paranjape, D. Gadkari, S.S. Kulkarni, N.G. Novak, R. Ingersoll, H.W. Sheppard, S.C. Ray, J. Virol. 73, 152 (1999)
M.S. Oberste, K. Maher, D.R. Kilpatrick, M.A. Pallansch, J. Virol. 73, 1941 (1999)
M.S. Oberste, W.A. Nix, K. Maher, M.A. Pallansch, J. Clin. Virol. 26, 375 (2003)
N.L. Yozwiak, P. Skewes-Cox, A. Gordon, S. Saborio, G. Kuan, A. Balmaseda, D. Ganem, E. Harris, J.L. DeRisi, J. Virol. 84, 9047 (2010)
C. Tapparel, T. Junier, D. Gerlach, S. Van-Belle, L. Turin, S. Cordey, K. Muhlemann, N. Regamey, J.D. Aubert, P.M. Soccal, P. Eigenmann, E. Zdobnov, L. Kaiser, Emerg. Infect. Dis. 15, 719 (2009)
T. Smura, S. Blomqvist, T. Hovi, M. Roivainen, Arch. Virol. 154, 1157 (2009)
M. Xu, L. Su, L. Cao, H. Zhong, N. Dong, J. Xu, BMC Infect. Dis. 13, 489 (2013)
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This work was supported by the Basic Research Projects of Yunnan Province (2013FZ136).
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Edited by Keizo Tomonaga.
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Zhu, Y., Pan, Y., Chen, J. et al. A Coxsackie B4 virus isolated in Yunnan in 2009 is a recombinant. Virus Genes 50, 375–380 (2015). https://doi.org/10.1007/s11262-015-1185-x
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DOI: https://doi.org/10.1007/s11262-015-1185-x