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The impact of preoperative anemia on oncologic outcome in patients undergoing radical cystectomy for urothelial carcinoma of the bladder

  • Urology - Original Paper
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Abstract

Purpose

To investigate the impact of preoperative anemia (PA) on oncologic outcomes among patients who underwent radical cystectomy (RC) for bladder cancer.

Methods

We reviewed the records of 200 patients undergoing RC between October 2003 and December 2014. Patients were categorized according to PA status. We performed multivariable Cox regression analyses to assess the impact of PA on oncological outcomes.

Results

Among 200 patients, 81 patients (40.5 %) had PA according to definition of the WHO classification. Fifty-two (26 %) of 200, 12 (6 %) of 200 and 61 (30.5 %) of 200 patients experienced the disease recurrence (DR), cancer-specific mortality (CSM) and all-cause mortality (ACM), respectively. In Kaplan–Meier analysis, the non-PA group showed a significantly higher 5-year DR-free survival than PA group (log-rank test: p = 0.018). The non-PA group showed a similar pattern of CSM and ACM (p = 0.004 and p = 0.037, respectively). In multivariable Cox proportional hazards analysis, PA was significantly associated with DR (HR 1.86, 95 % CI, p = 0.04) and ACM (HR 2.13, 95 % CI, p = 0.006) after adjusting other factors.

Conclusions

The preoperative anemic bladder cancer patients who underwent RC had worse oncological outcomes than non-anemic bladder cancer patients.

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Acknowledgments

This work was supported by Research Resettlement Fund for the new faculty of Seoul National University.

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Authors and Affiliations

  1. Department of Urology, Seoul National University Bundang Hospital, 82, Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Korea

    Jung Ki Jo, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee & Jong Jin Oh

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  1. Jung Ki Jo
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  2. Seong Jin Jeong
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  3. Sung Kyu Hong
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  4. Seok-Soo Byun
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Correspondence to Jong Jin Oh.

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All authors have no conflicts of interest with any institution or product.

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Jo, J.K., Jeong, S.J., Hong, S.K. et al. The impact of preoperative anemia on oncologic outcome in patients undergoing radical cystectomy for urothelial carcinoma of the bladder. Int Urol Nephrol 48, 489–494 (2016). https://doi.org/10.1007/s11255-016-1219-x

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  • DOI: https://doi.org/10.1007/s11255-016-1219-x

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