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Prevalence of chronic kidney disease and its association with cardio-metabolic risk factors in the adult Romanian population: the PREDATORR study

  • Nephrology - Original article
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Abstract

Purpose

PREDATORR is the first national study analyzing the prevalence of chronic kidney disease and its prognosis and association with socio-demographic, cardio-metabolic and lifestyle risk factors in the adult Romanian population.

Methods

Chronic kidney disease was defined according to the KDIGO 2012 criteria as an estimated glomerular filtration rate <60 mL/min/1.73 m2 and/or urinary albumin-to-creatinine ratio ≥30 mg/g. The socio-demographic, lifestyle and anamnestic data were collected through interviewer-administered questionnaires. Physical examination and biochemical assays were also performed.

Results

This cross-sectional study conducted between December 2012 and February 2014 in Romania included 2717 adults. The overall age- and sex-adjusted prevalence of chronic kidney disease was 6.74 % (95 %CI 5.60–7.88 %), of which 3.31 % (2.50–4.13 %) had only reduced kidney function (estimated glomerular filtration rate <60 mL/min/1.73 m2), 2.98 % (2.21–3.76 %) had only albuminuria, and 0.45 % (0.14–0.74 %) had both. The prevalence of chronic kidney disease increased with age and was similar in women and in men. Age, hyperuricemia, impaired glucose regulation (diabetes/prediabetes), hypertriglyceridemia and a family history of renal disease were independent risk factors for the presence of chronic kidney disease.

Conclusions

The PREDATORR study showed a high prevalence of chronic kidney disease in the adult Romanian population providing data on its prognosis and association with several cardio-metabolic risk factors.

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Acknowledgments

The authors would like to thank the 101 general practitioners who enrolled the participants, filled in the study questionnaires and collected blood and urine samples from the participants. They also acknowledge CEBIS International for study documentation development, feasibility, project management, monitoring, data management, statistical analysis and financial reporting. The authors thank Prof. Dr. Cristian Băicuș for review and validation of the statistical analyses and counseling regarding reporting of the study data. The authors also acknowledge Adriana Rusu and Iudit-Hajnal Filip (XPE Pharma & Science) for writing support. This work was supported by the Romanian Society of Diabetes, Nutrition and Metabolic Diseases, IHS Sofmedica, Abbott, Astra Zeneca, Novo Nordisk, MSD, Servier, Novartis and Worwag Pharma.

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    Authors and Affiliations

    1. Department of Nephrology, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania

      Eugen Moţa

    2. Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, 2-4 Petru Rares Street, Craiova, Romania

      Simona Georgiana Popa & Maria Moţa

    3. Emergency Clinical Hospital Craiova, Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy Craiova, Romania, 1 Tabaci Street, Craiova, Romania

      Maria Moţa & Adina Mitrea

    4. Department of Nephrology, University of Medicine and Pharmacy “Carol Davila” Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania

      Mircea Penescu, Liliana Gârneaţă, Constantin Verzan & Cristina Căpuşă

    5. Department of Nephrology, University “Ovidius” Constanta, 1 Aleea Universitatii, Constanta, Romania

      Liliana Tuţă

    6. Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy “Carol Davila” Bucharest, 8 Eroilor Sanitari Boulevard, Bucharest, Romania

      Cristian Serafinceanu, Radu Lichiardopol, Cornelia Zetu, Cristian Guja & Gabriela Radulian

    7. Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 2-4 Clinicilor Street, Cluj-Napoca, Romania

      Nicolae Hâncu, Cornelia Bala & Gabriela Roman

    8. Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 2 Victor Babes Street, Cluj-Napoca, Romania

      Dan Vlăduţiu

    9. Department of Diabetes, Nutrition and Metabolic Diseases, University “Ovidius” Constanta, 1 Aleea Universitatii, Constanta, Romania

      Doina Catrinoiu

    10. Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy “Victor Babes” Timisoara, 2 Piata Eftimie Murgu, Timisoara, Romania

      Romulus Timar

    11. Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, 16 Universitatii Street, Iasi, Romania

      Bogdan Mihai

    Authors
    1. Eugen Moţa
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    Corresponding author

    Correspondence to Maria Moţa.

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    Conflicts of interest

    The authors declare that they have no conflict of interest that could have direct or potential influence or impart bias on the work.

    Informed consent

    Informed consent was obtained from all individual participants included in the study.

    Research involving Human Participants and/or Animals

    All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

    Additional information

    Eugen Moţa, Simona Georgiana Popa, Maria Moţa and Adina Mitrea have contributed equally to this work.

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    Moţa, E., Popa, S.G., Moţa, M. et al. Prevalence of chronic kidney disease and its association with cardio-metabolic risk factors in the adult Romanian population: the PREDATORR study. Int Urol Nephrol 47, 1831–1838 (2015). https://doi.org/10.1007/s11255-015-1109-7

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    • DOI: https://doi.org/10.1007/s11255-015-1109-7

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