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A correlation between decreased parathyroid α-Klotho and fibroblast growth factor receptor 1 expression with pathological category and parathyroid gland volume in dialysis patients

  • Nephrology - Original Paper
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Abstract

Objectives

The objective of this study was to investigate α-Klotho and fibroblast growth factor receptor 1 (FGFR1) expression in hyperplastic parathyroid glands, as well as their role in the development of renal hyperparathyroidism.

Methods

Hyperplastic parathyroid glands (n = 90) were obtained from 24 patients who received parathyroidectomy due to secondary renal hyperparathyroidism. Normal parathyroid tissue was obtained from glands (n = 6) that were inadvertently removed, in conjunction with thyroidectomy, from patients with thyroid carcinoma. The expression of α-Klotho and FGFR1 in the parathyroid tissue was detected using immunohistochemical staining.

Results

The expression of α-Klotho and FGFR1 was significantly reduced in the hyperplastic parathyroid tissue compared to that in the normal parathyroid tissue. The expression of α-Klotho decreased further with increasing parathyroid pathology. A significant positive correlation was observed between α-Klotho and FGFR1 (r = 0.38, P < 0.01). FGFR1 (r = −0.21, P < 0.05) and α-Klotho (r = −0.42, P < 0.01) were negatively correlated with the volume of the hyperplastic parathyroid tissue.

Conclusion

The expression of α-Klotho and FGFR1 decreases in the parathyroid glands of dialysis patients with secondary hyperparathyroidism, and this decrease may play an important role in the pathogenesis of secondary renal hyperparathyroidism.

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Acknowledgments

The authors thank Mr. Dake Huang and Xian Wang for their excellent technical assistance.

Conflict of interest

All authors have no conflict of interest regarding this paper.

Author information

Authors and Affiliations

  1. Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China

    Junfang Yan, Deguang Wang, Liang Yuan & Li Hao

  2. Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 000800, China

    Chen Jingbo

  3. Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China

    Shengxue Xie

  4. Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China

    Xing Zhong

Authors
  1. Junfang Yan
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  2. Chen Jingbo
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  3. Deguang Wang
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  4. Shengxue Xie
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  5. Liang Yuan
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  6. Xing Zhong
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  7. Li Hao
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Correspondence to Li Hao.

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Yan, J., Jingbo, C., Wang, D. et al. A correlation between decreased parathyroid α-Klotho and fibroblast growth factor receptor 1 expression with pathological category and parathyroid gland volume in dialysis patients. Int Urol Nephrol 47, 701–706 (2015). https://doi.org/10.1007/s11255-015-0917-0

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  • DOI: https://doi.org/10.1007/s11255-015-0917-0

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