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Antioxidant and antimicrobial properties of nickel(II), cobalt(III), and zinc(II) complexes of a Schiff base ligand

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Abstract

A series of mononuclear Ni(II), Co(III), and Zn(II) complexes based on a Schiff base ligand, 4-chloro-6-[2-(pyrazin-2-ylmethylene)hydrazinyl]pyrimidine (HL), have been synthesized and characterized by physicochemical and spectroscopic methods. The complexes were found to have superior radical scavenging potency against DPPH, superoxide anion, hydroxyl, and ABTS radicals than free HL. The antibacterial effects of the complexes against Gram-positive and Gram-negative bacteria were also higher than that of free HL.

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References

  1. Abdel Aziz AA, Elbadawy HA (2014) Spectrochim Acta A 124:404

    Article  CAS  Google Scholar 

  2. Sathiyaraj S, Sampath K, Butcher RJ, Pallepogu R, Jayabalakrishnan C (2013) Eur J Med Chem 64:81

    Article  CAS  Google Scholar 

  3. Suksrichavalit T, Prachayasittikul S, Nantasenamat C, Na-Ayudhya CI, Prachayasittikul V (2009) Eur J Med Chem 44:3259

    Article  CAS  Google Scholar 

  4. Chen WJ, Guo P, Song J, Cao W, Bian J (2006) Bioorg Med Chem Lett 16:3582

    Article  CAS  Google Scholar 

  5. Asayama S, Mizushima K, Nagaoka S, Kawakami H (2004) Bioconjugate Chem 15:1360

    Article  CAS  Google Scholar 

  6. Imlay JA (2002) J Biol Inorg Chem 7:659

    Article  CAS  Google Scholar 

  7. Dreher D, Junod AF (1996) Eur J Cancer 32:30

    Article  Google Scholar 

  8. Dexter DT, Sian J, Rose S (1994) Ann Neurol 53:38

    Article  Google Scholar 

  9. Ray PS, Maulik G, Cordis GA, Bertelli AAE, Bertelli A, Das DK (1999) Free Radical Biol Med 27:160

    Article  CAS  Google Scholar 

  10. Elke F, Hasan S, Hanna GS, Dimitris AS, Reza GA (2011) Biomacromolecules 12:3528–3539

    Article  Google Scholar 

  11. Satheesh CE, Raghavendra Kumar P, Sharma P, Lingaraju K, Palakshamurthy BS, Raja Naika H (2016) Inorg Chim Acta 442:1

    Article  CAS  Google Scholar 

  12. Medici S, Peanaa M, Nurchi VM, Lachowicz JI, Crisponi G, Zoroddua MA (2015) Coord Chem Rev 284:329

    Article  CAS  Google Scholar 

  13. Patel MN, Patel CR, Joshi HN (2013) Inorg Chem Commun 27:51

    Article  CAS  Google Scholar 

  14. Raja DS, Bhuvanesh NSP, Natarajan K (2012) Dalton Trans 41:4365

    Article  CAS  Google Scholar 

  15. Sathyadevi P, Krishnamoorthy P, Butorac RR, Cowley AH, Bhuvanesh NSP, Dharmaraj N (2011) Dalton Trans 40:9690

    Article  CAS  Google Scholar 

  16. Nahid S, Zeinab G, Saba H (2012) Bioinorg Chem Appl 10:126451

    Google Scholar 

  17. Elizabeth K, Rao MNA (1990) Int J Pharm 58:237–240

    Article  Google Scholar 

  18. Winterbourn CC (1981) Biochem J 198:125

    Article  CAS  Google Scholar 

  19. Winterbourn CC (1979) Biochem J 182:625

    Article  CAS  Google Scholar 

  20. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Evans CR (1999) Biol Med 26:1231

    CAS  Google Scholar 

  21. Li Y, Yang ZY, Wu JC (2010) Eur J Med Chem 45:5692–5701

    Article  CAS  Google Scholar 

  22. Liang YT, Yang GP, Liu B (2015) Dalton Trans 44:13325–13330

    Article  CAS  Google Scholar 

  23. Kime NE, Ibers JA (1969) Acta Crystallogr B 25:168–169

    Article  CAS  Google Scholar 

  24. Min KS, DiPasquale AG, Golen JA, Rheingold AL, Miller JS (2007) J Am Chem Soc 129:2360

    Article  CAS  Google Scholar 

  25. Kil SM, Antonio GD, Arnold LR, Henry SW, Joel SM (2009) J Am Chem Soc 131:6229–6236

    Article  Google Scholar 

  26. Grünwald KR, Volpe M, Cias P, Gescheidt G (2011) Inorg Chem 50:7478–7488

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from the Natural Science Foundation of China (Nos. 21461023 and 21361023), Fundamental Research Funds for the Gansu Universities.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People’s Republic of China

    Qi-Meige Hasi, Yan Fan, Xiao-Xia Feng, Xiao-Qiang Yao & Jia-Cheng Liu

  2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, People’s Republic of China

    Qi-Meige Hasi, Yan Fan, Xiao-Xia Feng, Xiao-Qiang Yao & Jia-Cheng Liu

Authors
  1. Qi-Meige Hasi
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  2. Yan Fan
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  3. Xiao-Xia Feng
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Corresponding author

Correspondence to Jia-Cheng Liu.

Electronic supplementary material

Below is the link to the electronic supplementary material.

11243_2016_69_MOESM1_ESM.doc

CCDC 1434915 (1), CCDC 1434912 (2), CCDC 1434917 (3), CCDC 1434916 (4), and CCDC 1434913 (5) include all supplementary crystallographic data of three complexes. These data can be obtained free of charge from The Cambridge Crystallographic Data Center via http://www.ccdc.cam.ac.uk/data_request/cif. (DOC 3309 kb)

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Hasi, QM., Fan, Y., Feng, XX. et al. Antioxidant and antimicrobial properties of nickel(II), cobalt(III), and zinc(II) complexes of a Schiff base ligand. Transit Met Chem 41, 685–692 (2016). https://doi.org/10.1007/s11243-016-0069-9

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  • DOI: https://doi.org/10.1007/s11243-016-0069-9

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