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Circulating activated protein C in thrombophilia carriers

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References

  1. Griffin JH, Zlokovic BV, Mosnier LO (2015) Activated protein C: biased for translation. Blood 125:2898–2907

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Weiler H (2014) Inflammation-associated activation of coagulation and immune regulation by the protein C pathway. Thromb. Res. 133(Suppl):S32–S34

    Article  PubMed  PubMed Central  Google Scholar 

  3. van Mens TE, Levi M, Middeldorp S. (2013) Evolution of factor V leiden. Thromb Haemost 110:23–30

    Article  PubMed  Google Scholar 

  4. Petäjä J, Hakala L, Rasi V, Griffin JH (1998) Circulating activated protein C in subjects with heterozygous Gln506-factor V. Haemostasis 28:31–36

    PubMed  Google Scholar 

  5. Faioni E, Franchi F (1998) Activation of the protein C pathway in hereditary thrombophilia. Thromb Haemost 80:557–560

    CAS  PubMed  Google Scholar 

  6. Strandberg K, Svensson PJ, Ohlin A-K (2007) Venous thromboembolism in carriers of the factor V leiden mutation and in patients without known thrombophilic risk factor; prediction of recurrence and APC-PCI complex concentration and/or soluble thrombomodulin antigen and activity. Thromb Res 121:145–151

    Article  CAS  PubMed  Google Scholar 

  7. Meijers JCM, Herwald H (2011) Protein C inhibitor. Semin Thromb Hemost 37:349–354

    Article  CAS  PubMed  Google Scholar 

  8. Müller J et al (2012) Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay. J Thromb Haemost 10:390–398

    Article  PubMed  Google Scholar 

  9. Liaw, P. C. Y., Ferrell G, Esmon CT (2003) A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation. J Thromb Haemost 1:662–670

    Article  CAS  PubMed  Google Scholar 

  10. Gruber A, Griffin JH (1992) Direct detection of activated protein C in blood from human subjects. Blood 79:2340–2348

    CAS  PubMed  Google Scholar 

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Acknowledgements

We thank J.A. Marquart and W. Kopatz for laboratory assistance.

Funding

This study was funded by the Netherlands Organisation for Scientific Research (NWO, VIDI innovative research Grant 016.126.364 awarded to S. Middeldorp).

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Authors and Affiliations

  1. Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, F4-136, 1105 AZ, Amsterdam, The Netherlands

    Thijs E. van Mens & Saskia Middeldorp

  2. Department of Plasma Proteins, Sanquin Research, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands

    Joost C. M. Meijers

  3. Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    Joost C. M. Meijers

Authors
  1. Thijs E. van Mens
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  2. Joost C. M. Meijers
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  3. Saskia Middeldorp
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Correspondence to Thijs E. van Mens.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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van Mens, T.E., Meijers, J.C.M. & Middeldorp, S. Circulating activated protein C in thrombophilia carriers. J Thromb Thrombolysis 43, 361–364 (2017). https://doi.org/10.1007/s11239-016-1472-y

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  • DOI: https://doi.org/10.1007/s11239-016-1472-y

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