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Synthesis of methylene-bis(1-oxy-3,3-dialkyl-1-triazene 2-oxides) and their analogs

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Abstract

Synthetic procedures towards methylene-bis(1-oxy-3,3-dialkyl-1-triazene 2-oxides), the first representatives of a new class of promising exogenous nitric oxide (NO) donors, which can release NO in living organisms, were developed. Synthesis involves the reactions of salts of 1-hydroxy-3,3-dialkyl-1-triazene 2-oxides with either dibromomethane or 1-chloromethoxy-3,3-dialkyl-1-triazene 2-oxides.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    G. A. Smirnov, P. B. Gordeev, S. V. Nikitin, G. V. Pokhvisneva, T. V. Ternikova & O. A. Luk´yanov

Authors
  1. G. A. Smirnov
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  2. P. B. Gordeev
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  3. S. V. Nikitin
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  4. G. V. Pokhvisneva
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  5. T. V. Ternikova
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  6. O. A. Luk´yanov
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Corresponding author

Correspondence to G. A. Smirnov.

Additional information

On the occasion of the 100th anniversary of the birth of Academician N. K. Kochetkov (1915—2005).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1057—1061, May, 2015.

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Smirnov, G.A., Gordeev, P.B., Nikitin, S.V. et al. Synthesis of methylene-bis(1-oxy-3,3-dialkyl-1-triazene 2-oxides) and their analogs. Russ Chem Bull 64, 1057–1061 (2015). https://doi.org/10.1007/s11172-015-0976-5

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  • DOI: https://doi.org/10.1007/s11172-015-0976-5

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