Skip to main content
SpringerLink
Log in

Metal polyacrylates, ferrocene derivatives, and polysuccinimide as potential antitumor drugs

  • Full Articles
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

Compounds belonging to three novel groups of oncological drugs (metal polyacrylates, ferrocene derivatives, and polysuccinimide) showed antitumor activity. The most efficient compounds, viz., gold polyacrylate (auracryl), 2-[(1-ferrocenylethyl)sulfanyl]pyrimidine (LS-17), and polysuccinimide, inhibit the growth of murine solid tumors by 70–95% and are recommended for further thorough preclinical studies of their antitumor properties and mechanisms of action.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. B. Korman, Osnovy protivoopukholevoi khimioterapii [The Foundations of Antitumor Chemotherapy], Prakticheskaya Meditsina, Moscow, 2006, 503 pp. (in Russian).

    Google Scholar 

  2. E. M. Treshchalina, O. S. Zhukova, G. K. Gerasimova, N. V. Andronova, A. M. Garin, in Rukovodstvo po eksperimental’nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv [A Guide to Experimental (Preclinical) Testing of New Pharmaceuticals], Ed. R. U. Khabriev, Meditsina, Moscow, 2005, p. 637 (in Russian).

  3. L. A. Ostrovskaya, M. G. Voronkov, D. B. Korman, M. M. Fomina, N. V. Bluhterova, B. A. Rikova, K. A. Abzaeva, L. V. Zhilitskaya, J. Cancer Ther., 2010, 1, 59.

    Article  CAS  Google Scholar 

  4. K. A. Abzaeva, M. G. Voronkov, L. V. Zhilitskaya, L. A. Ostrovskaya, M. M. Fomina, N. V. Bluchterova, V. A. Rikova, Zh. Fiz. Khim., 2012, 46, 11 [Russ. J. Phys. Chem. (Engl. Transl.), 2012, 46].

    Google Scholar 

  5. A. A. Simenel, G. Dokuchaeva, L. V. Snegur, S. I. Zykova, A. N. Rodionov, M. M. Ilyin, L. A. Ostrovskaya, N. V. Bluchterova, M. M. Fomina, V. A. Rikova, Appl. Organomet. Chem., 2011, 25, 70.

    Article  CAS  Google Scholar 

  6. L. V. Snegur, V. N. Babin, A. A. Simenel, Yu. S. Nekrasov, L. A. Ostrovskaya, N. S. Sergeeva, Russ. Chem. Bull., Int. Ed., 2010, 59, 2167 [Izv. Akad. Nauk, Ser. Khim., 2010, 2113].

    Article  CAS  Google Scholar 

  7. L. V. Snegur, A. A. Simenel, A. N. Rodionov, V. I. Boev, Russ. Chem. Bull., Int. Ed., 2014, 63, 26 [Izv. Akad. Nauk, Ser. Khim., 2014, 26].

    Article  CAS  Google Scholar 

  8. V. M. Goldberg, S. M. Lomakin, A. V. Todinova, A. N. Shchegolikhin, S. D. Varfolomeev, Dokl. Akad. Nauk, 2008, 423, 423 [Dokl. Chem. (Engl. Transl.), 2008, 423].

    Google Scholar 

  9. V. M. Goldberg, S. M. Lomakin, A. V. Todinova, A. N. Shchegolikhin, Dokl. Akad. Nauk, 2009, 429, 627 [Dokl. Chem. (Engl. Transl.), 2009, 429].

    Google Scholar 

  10. V. M. Goldberg, S. M. Lomakin, A. V. Todinova, A. N. Shchegolikhin, S. D. Varfolomeev, Russ. Chem. Bull., Int. Ed., 2010, 59, 806 [Izv. Akad. Nauk, Ser. Khim., 2010, 790].

    Article  CAS  Google Scholar 

  11. V. M. Goldberg, A. V. Todinova, A. N. Shchegolikhin, S. D. Varfolomeev, Vysokomol. Soedin., Ser. A, 2010, 52, No. 10, 1 [Polym. Sci., Ser. A, 2010, 52, No. 10].

    Google Scholar 

  12. RF Pat. No. 2372091, 2009; Byull. Izobret. [Bulletin of Inventions], 2009, 31.

  13. M. G. Voronkov, L. A. Ostrovskaya, D. B. Korman, N. V. Bluchterova, M. M. Fomina, V. A. Rikova, K. A. Abzaeva, L. V. Zhilitskaya, Tezisy dokladov IX Vserossiiskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem “Otechestvennye protivoopukholevye preparaty” [Abstrs, IX All-Russia Scientific and Practical Conf. with international participation “Domestic Antitumor Drugs”] (May 18–19, 2010, Nizhny Novgorod), Nizhny Novgorod, 2010 (in Russian)

    Google Scholar 

  14. M. G. Voronkov, L. A. Ostrovskaya, D. B. Korman, N. V. Bluchterova, M. M. Fomina, V. A. Rikova, K. A. Abzaeva, L. V. Zhilitskaya, Ross. Bioter. Zh. [Russian Biotherapeutical Journal], 2010, 9, No. 2, 67 (in Russian).

    Google Scholar 

  15. L. A. Ostrovskaya, B. Ya. Kogan, G. N. Vorozhtsov, M. G. Voronkov, M. M. Fomina, N. V. Bluchterova, V. A. Rikova, K. A. Abzaeva, L. V. Zhilitskaya, Tezisy dokladov X Vserossiiskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem “Otechestvennye protivoopukholevye preparaty” [Abstrs, X All-Russia Scientific and Practical Conf. with international participation “Domestic Antitumor Drugs”] (March 22–23, 2011, Moscow), Moscow, 2011 (in Russian)

    Google Scholar 

  16. L. A. Ostrovskaya, B. Ya. Kogan, G. N. Vorozhtsov, M. G. Voronkov, M. M. Fomina, N. V. Bluchterova, V. A. Rikova, K. A. Abzaeva, L. V. Zhilitskaya, Ross. Bioter. Zh. [Russian Biotherapeutical Journal], 2011, 10, No. 1, 45 (in Russian).

    Google Scholar 

  17. L. V. Snegur, A. A. Simenel, Yu. S. Nekrasov, E. A. Morozova, Z. A. Starikova, S. M. Peregudova, Yu. V. Kuzmenko, V. N. Babin, L. A. Ostrovskaya, N. V. Bluchterova, M. M. Fomina, J. Organomet. Chem., 2004, 689, 2473.

    Article  CAS  Google Scholar 

  18. L. V. Snegur, Yu. S. Nekrasov, N. S. Sergeeva, L. A. Ostrovskaya, N. V. Bluchterova, M. M. Fomina, V. A. Rikova, Appl. Organomet. Chem., 2008, 22, 139.

    Article  CAS  Google Scholar 

  19. A. A. Simenel, S. V. Samarina, L. V. Snegur, Z. Starikova, L. A. Ostrovskaya, N. V. Bluchterova, V. A. Rikova, M. M. Fomina, J. Organomet. Chem., 2008, 22, 276.

    Article  CAS  Google Scholar 

  20. A. A. Simenel, E. A. Morozova, L. V. Snegur, S. I. Zykova, V. V. Kachala, L. A. Ostrovskaya, N. V. Bluchterova, M. M. Fomina, V. A. Rikova, Appl. Organomet. Chem., 2009, 23, 219.

    Article  CAS  Google Scholar 

  21. J. Kovacs, I. Könuves, Naturwissenschaften, 1954, 41, 333.

    Article  CAS  Google Scholar 

  22. S. D. Varfolomeev, L. A. Ostrovskaya, D. B. Korman, V. M. Goldberg, N. V. Bluchterova, M. M. Fomina, V. A. Rikova, Tezisy dokladov Pervoi rossiiskoi konferentsii po meditsinskoi khimii s mezhdunarodnym uchastiem “MedChem Russia-2013” [Abstrs, First Russian Conf. on medicinal chemistry with international participation “MedChem Russia-2013”] (September 8–12, 2013, Moscow), Moscow, 2013, 293 (in Russian).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119991, Moscow, Russian Federation

    L. A. Ostrovskaya, S. D. Varfolomeev, D. B. Korman, N. V. Bluchterova, M. M. Fomina, V. A. Rikova & V. M. Goldberg

  2. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 ul. Favorskogo, 664033, Irkutsk, Russian Federation

    M. G. Voronkov, K. A. Abzaeva & L. V. Zhilitskaya

  3. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    L. V. Snegur, A. A. Simenel & S. I. Zykova

Authors
  1. L. A. Ostrovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. D. Varfolomeev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. G. Voronkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. B. Korman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. V. Bluchterova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. M. Fomina
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. V. A. Rikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. V. M. Goldberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. K. A. Abzaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. L. V. Zhilitskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. L. V. Snegur
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. A. A. Simenel
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. S. I. Zykova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. A. Ostrovskaya.

Additional information

Based on the materials of the First Russian Conference on Medicinal Chemistry (“MedChem Russia-2013”) with International Participation (September 8–12, 2013, Moscow).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1211–1218, May, 2014.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ostrovskaya, L.A., Varfolomeev, S.D., Voronkov, M.G. et al. Metal polyacrylates, ferrocene derivatives, and polysuccinimide as potential antitumor drugs. Russ Chem Bull 63, 1211–1217 (2014). https://doi.org/10.1007/s11172-014-0575-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11172-014-0575-x

Key words

Search

Navigation