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A review from patents inspired by the genus Cannabis

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Abstract

Specialized or secondary metabolism of plants from the genus Cannabis has been widely studied, generating a huge investment in research and development of patents. This review highlights the most recent patents granted so far, with some exceptions, covering different areas of knowledge including biotechnological aspects of plant specialized/secondary metabolism. Several patent databases were consulted in order to collect patent information. There are patents for specialized/secondary metabolite isolation methods, synthesis, production, genes, development of medicaments, drug delivery systems, equipment, machines, industrial processes, plant culture techniques, improved plant varieties, among others. Furthermore, important aspects such as nutrition and fiber production having unlimited applications in several areas are discussed. Endocannabinoid system is a special topic that has been included in this review due to interconnections among cannabinoids, endocannabinoids and its medical effects in human beings. This review of the state-of-the-art about Cannabis patents has the potential to be a valuable source of organized information for those researchers developing projects in many aspects related to this important natural resource.

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Abbreviations

2-AG:

2-Arachidonoylglycerol

Abh4:

α/β-Hydrolase 4

CBCA:

Cannabichromenic acid

CBD:

Cannabidiol

CBDA:

Cannabidiolic acid

CBGA:

Cannabigerolic acid

CBGVA:

Cannabigerovarinic acid

CB receptor:

Cannabinoid receptor

CO2 :

Carbon dioxide

FAAH:

Fatty acid amide hydrolase

FABP:

Fatty acid binding protein

GPP:

Geranyl diphosphate

GPR:

G protein-coupled receptor

MGL:

Monoacylglicerol lipase

NAAA:

N-acylethanolamine-hydrolyzing acid amidase

NAPE-PLD:

N-acyl-phosphatidyl-ethanolamine-hydrolyzing phospholipase D

THC:

Tetrahydrocannabinol

THCA:

Tetrahydrocannabinolic acid

THCVA:

Tetrahydrocannabivarinic acid

TRPV1:

Transient receptor potential cation channel subfamily V member 1

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Acknowledgements

I.J.F.S. received a postdoctoral fellowship from CONACYT (Mexico). We thank to Prof.em.dr. Robert Verpoorte (IBL, Leiden University, The Netherlands) for his helpful discussions.

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  1. Departamento de Biotecnología y Bioingeniería, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Av. IPN 2508, Col. San Pedro Zacatenco, 07360, Mexico City, Mexico

    Isvett Josefina Flores-Sanchez & Ana Carmela Ramos-Valdivia

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Correspondence to Ana Carmela Ramos-Valdivia.

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Flores-Sanchez, I.J., Ramos-Valdivia, A.C. A review from patents inspired by the genus Cannabis . Phytochem Rev 16, 639–675 (2017). https://doi.org/10.1007/s11101-016-9485-x

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