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Using national data to describe characteristics and determine acceptance factors of pharmacists’ interventions: a six-year longitudinal study

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Abstract

Background

In France, hospital pharmacists perform medication order reviews during patients’ hospital stays. This activity can be centralized in the pharmacy or carried out directly in the ward, in collaboration with the healthcare team. During this review, pharmacists can make recommendations to optimize therapeutics. Since 2006, they can document their interventions, via the national Act-IP© observatory.

Aim

To determine the characteristics of pharmacists’ interventions and their acceptance by physicians in French hospitals.

Method

A 6-year observational study of pharmacists’ interventions documented on the Act-IP© French observatory between 2009 and 2014 was performed. Multiple logistic regression was undertaken to determine the predictors of physicians’ acceptance of interventions.

Results

A total of 194,684 pharmacists’ interventions were documented and concerned mainly “dosage adjustment” (25.6%). These interventions were mostly related to drugs from the central nervous system (23.7%). Seventy percent of pharmacists’ interventions were accepted by physicians. Acceptance rate was higher when conducted by a pharmacist regularly practicing in the ward (ORa = 1.60, CI 95 [1.57–1.64]). Physicians’ acceptance was significantly associated with (1) ward specialty: emergency (ORa = 1.24, CI 95 [1.14–1.35]); (2) type of intervention: “drug discontinuation”, “drug switch” (ORa = 1.15, CI 95 [1.12–1.19]) and “addition of a new drug” (ORa = 1.15, CI 95 [1.12–1.19]); (3) drug group: antineoplastic and immunomodulators (ORa = 3.67, CI 95 [3.44–3.92]).

Conclusion

This 6-year longitudinal study highlights the role of clinical pharmacists, and particularly the impact of those integrated into wards. This was found to improve intervention acceptance, potentially through collaboration with physicians in pursuit of patient care and drug safety.

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Acknowledgements

The authors would like to thank Dominique Macabiès, professional English-speaking editor (https://dominique.macabies.fr/en/), for the English translation. The authors would like to thank the Lebanese University for their support with a PhD grant (MBZ). The authors would like to thank the team of TIMC and VIP working group for assistance in this project. We thank the SFPC Act-IP© group’s clinical pharmacists who participated in data collection. Members of the working group “Valorization of Pharmaceutical Interventions/ Valorisation des Interventions Pharmaceutiques – Act-IP©” of the French Society for Clinical Pharmacy: Pierrick Bedouch (Grenoble), Magalie Bourdelin (Villefranche-sur-Saone), Bruno Charpiat (Lyon), Ornella Conort (Paris), Julien Gravoulet (Leyr), Audrey Janoly-Dumenil (Lyon), Michel Juste (Epernay), and Céline Mongaret (Reims). The authors also thank Kévin Mastrorillo, Act-IP© observatory technical consultant, for his contribution.

Funding

No specific funding was received.

Author information

Authors and Affiliations

  1. CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Univ. Grenoble Alpes, 38000, Grenoble, France

    Mayssam Bouzeid, Hélène Pluchart, Sébastien Chanoine, Céline Vermorel, Jean-Luc Bosson & Pierrick Bedouch

  2. BIOS EA 4691, Université de Reims Champagne-Ardenne, 51100, Reims, France

    Justine Clarenne & Céline Mongaret

  3. Pharmacy Department, CHU Reims, 51100, Reims, France

    Justine Clarenne & Céline Mongaret

  4. Pharmacy Department, Grenoble-Alpes University Hospital, 38000, Grenoble, France

    Hélène Pluchart, Sébastien Chanoine & Pierrick Bedouch

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  1. Mayssam Bouzeid
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Consortia

SFPC VIP– Act-IP© group

  • Pierrick Bedouch
  • , Magalie Bourdelin
  • , Bruno Charpiat
  • , Ornella Conort
  • , Julien Gravoulet
  • , Audrey Janoly-Dumenil
  • , Michel Juste
  •  & Céline Mongaret

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Correspondence to Pierrick Bedouch.

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SFPC VIP– Act-IP© group: Working group “Valorization of Pharmacists’ Interventions/ Valorisation des Interventions Pharmaceutiques – Act-IP©” of the French Society for Clinical Pharmacy (see composition and members in acknowledgments).

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Bouzeid, M., Clarenne, J., Mongaret, C. et al. Using national data to describe characteristics and determine acceptance factors of pharmacists’ interventions: a six-year longitudinal study. Int J Clin Pharm 45, 430–441 (2023). https://doi.org/10.1007/s11096-022-01526-0

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