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An Overview of the Mechanisms of Abnormal GABAergic Interneuronal Cortical Migration Associated with Prenatal Ethanol Exposure

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Abstract

GABAergic Interneuronal migration constitutes an essential process during corticogenesis. Derived from progenitor cells located in the proliferative zones of the ventral telencephalon, newly generated GABAergic Interneuron migrate to their cortical destinations. Cortical dysfunction associated with defects in neuronal migration results in severe developmental consequences. There is growing evidence linking prenatal ethanol exposure to abnormal GABAergic interneuronal migration and subsequent cortical dysfunction. Investigating the pathophysiological mechanisms behind disrupted GABAergic interneuronal migration encountered with prenatal alcohol exposure is crucial for understanding and managing fetal alcohol spectrum disorders. This review explores the molecular pathways regulating GABAergic interneuronal cortical migration that might be altered by prenatal ethanol exposure thus opening new avenues for further research in this topic.

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Acknowledgements

I would like to express my sincere thanks and appreciation to Dr. Seena Ajit, Drexel University College of Medicine for her continuous support and encouragement. I acknowledge the help of Diana Winters in editing the review. The author is a recipient of the Fulbright Foreign Student Program fellowship funded by the US Department of State, Bureau of Educational and Cultural Affairs and Dean’s Fellowship for Excellence in Collaborative or Themed Research, Graduate School of Biomedical Sciences and Professional Studies, Drexel University.

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  1. Pharmacology and Physiology, Drexel University College of Medicine, 245 North 15th Street, Mail Stop 488, Philadelphia, PA, 19102, USA

    Botros B. Shenoda

  2. Department of Pharmacology, Assiut University College of Medicine, Assiut, Egypt

    Botros B. Shenoda

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Shenoda, B.B. An Overview of the Mechanisms of Abnormal GABAergic Interneuronal Cortical Migration Associated with Prenatal Ethanol Exposure. Neurochem Res 42, 1279–1287 (2017). https://doi.org/10.1007/s11064-016-2169-5

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  • DOI: https://doi.org/10.1007/s11064-016-2169-5

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