Abstract
Bacopa monniera is a well-known medhya-rasayana (memory enhancing and rejuvenating) plant in Indian traditional medical system of Ayurveda. The effect of a standardized extract of Bacopa monniera (BESEB CDRI-08) on serotonergic receptors and its influence on other neurotransmitters during hippocampal-dependent learning was evaluated in the present study. Wistar rat pups received a single dose of BESEB CDRI-08 during postnatal days 15–29 showed higher latency during hippocampal-dependent learning accompanied with enhanced 5HT3A receptor expression, serotonin and acetylcholine levels in hippocampus. Furthermore, 5HT3A receptor agonist 1-(m-chlorophenyl)-biguanide (mCPBG) impaired learning in the passive avoidance task followed by reduction of 5HT3A receptor expression, 5HT and ACh levels. Administration of BESEB CDRI-08 along with mCPBG attenuated mCPBG induced behavioral, molecular and neurochemical alterations. Our results suggest that BESEB CDRI-08 possibly acts on serotonergic system, which in turn influences the cholinergic system through 5-HT3 receptor to improve the hippocampal-dependent task.
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Acknowledgments
KER is thankful to Lumen Marketing Company (Chennai, India) for providing the standardised B. monniera extract (BESEB CDRI-08). This work was partially supported by Department of Atomic Energy through Young Scientists Program to KER (2006/20/37/3/BRNS/2377/2007) and UGC-SAP Program to Department of Animal Science. We thank Ambigapathy Ganesh for assistance with documentation.
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Emmanuvel Rajan, K., Singh, H.K., Parkavi, A. et al. Attenuation of 1-(m-Chlorophenyl)-Biguanide Induced Hippocampus-Dependent Memory Impairment by a Standardised Extract of Bacopa monniera (BESEB CDRI-08). Neurochem Res 36, 2136–2144 (2011). https://doi.org/10.1007/s11064-011-0538-7
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DOI: https://doi.org/10.1007/s11064-011-0538-7