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An exploratory survival analysis of anti-angiogenic therapy for recurrent malignant glioma

  • Clinical Study - Patient Study
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Abstract

Recent clinical trial results suggest that anti-angiogenic therapy may be effective against recurrent malignant glioma. Though these treatments prolong progression-free survival, the extent to which they prolong overall survival is unknown. We pooled data from 34 patients treated at a single institution on phase II clinical trials of bevacizumab and cediranib, and we compared these data to 18 patients treated on clinical trials of cytotoxic chemotherapies. In univariate and multivariate analyses, treatment group was a significant predictor of progression-free but not overall survival. Median progression-free survival was 8 vs. 22 weeks in patients treated with cytotoxic as compared to anti-angiogenic therapy (P = 0.01). Median overall survival was nearly identical in the two groups (39 vs. 37 weeks). The results of this exploratory analysis suggest that anti-angiogenic therapy may fail to prolong overall survival in patients with recurrent malignant glioma. If this conclusion proves correct, progression-free survival may be an inappropriate endpoint for phase II trials of anti-angiogenic therapies.

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Authors and Affiliations

  1. Division of Neuro-Oncology, Department of Neurology, Brigham and Women’s Hospital, 75 Francis St, Boston, MA, 02115, USA

    Andrew D. Norden, Jan Drappatz, Santosh Kesari & Patrick Y. Wen

  2. Center for Neuro-Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA, 02115, USA

    Andrew D. Norden, Jan Drappatz, Karly David, Mary Gerard, M. Brenna McNamara, Phuong Phan, Ainsley Ross, Santosh Kesari & Patrick Y. Wen

  3. Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA

    Andrew D. Norden, Jan Drappatz, Santosh Kesari & Patrick Y. Wen

  4. Massachusetts General Hospital Biostatistics Center, 50 Staniford St, Boston, MA, 02114, USA

    Alona Muzikansky

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  1. Andrew D. Norden
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  2. Jan Drappatz
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  3. Alona Muzikansky
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  4. Karly David
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  8. Ainsley Ross
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  9. Santosh Kesari
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  10. Patrick Y. Wen
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Correspondence to Andrew D. Norden.

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Norden, A.D., Drappatz, J., Muzikansky, A. et al. An exploratory survival analysis of anti-angiogenic therapy for recurrent malignant glioma. J Neurooncol 92, 149–155 (2009). https://doi.org/10.1007/s11060-008-9745-8

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  • DOI: https://doi.org/10.1007/s11060-008-9745-8

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