The aim of the present work was to analyze the ultrastructural changes developing in cerebral histaminergic neurons in 24 mongrel white male rats after administration of ethanol in acute experimental conditions (single i.p. doses of 1 and 4 g/kg), in subacute conditions (sole source of drinking fluid, 4 g/kg, for 7 days), or chronic conditions (2–3 g/kg/day for 6 months). Administration of alcohol led to the development of a variety of ultrastructural changes in the nuclei and organelles of histaminergic neurons. These reflect neuron destruction processes and adaptive changes directed at restoring and maintaining cell functions. These changes were nonspecific in nature and depended on dose, time after administration, and duration of treatment; overall, they corresponded to structural and histochemical changes detected at the light microscope level.
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References
S. M. Zimatkin, The Histaminergic System of the Brain: A Monograph, Grodno State Medical University, Grodno (2007).
S. M. Zimatkin and E. I. Bon’, “The histaminergic system of the brain and alcohol,” Zh. Grod. Gos. Med. Univ., No. 1, 27–30 (2009).
S. M. Zimatkin, V. B. Kuznetsov, and O. N. Strik, “Spatial organization and morphometric characterization of histaminergic neurons in the rat brain,” Morfologiya, 127, No. 2, 27–30 (2005).
S. M. Zimatkin and E. M. Fedina, “Histaminergic neurons in the rat brain after chronic alcohol intoxication,” Nov. Med.-Biol. Nauk., 5, No. 2, 137–144 (2012).
S. M. Zimatkin, E. M. Fedina, and V. B. Kuznetsov, “Histaminergic neurons in the rat brain after acute exposure to alcohol,” Morfologiya, 142, No. 5, 17–22 (2012).
P. A. Ivanov and E. S. Nadezhdina, “Stress granules: RNA-containing cytoplasmic bodies arising in response to stress. Composition and mechanism of formation,” Mol. Biol., 40, No. 6, 937–944 (2006).
A. A. Manina, Ultrastructural Changes and Repair Processes in the Central Nervous System in Response to Various Treatments, Meditsina, Leningrad (1971).
E. M. Fedina and S. M. Zimatkin, “Effects of seven days of alcohol intoxication on histaminergic neurons in the rat brain,” Zh. Grod. Gos. Med. Univ., No. 3, 43–45 (2012).
Z. R. Khismatullinia, A. V. Akhmadeev, L. A. Sharafutdinova, and L. B. Kalimullina, “Cytological characteristics of neurons in the anterior amygdalar area and their reactive changes on the background of different levels of sex steroids,” Tsitologiya, 5, No. 5, 381–387 (2008).
H. Haas, O. Sergeeva, and O. Selback, “Histamine in the nervous system,” Physiol. Rev., 88, No. 3, 1183–1241 (2008).
N. Inagaki, K. Toda, and I. Taniuchi, “The five subgroups of the tuberomammillary nucleus of the rat: an analysis of the histaminergic efferent projections to the medial preoptic area and inferior colliculus,” Exp. Brain Res., 80, 374–380 (1990).
I. Kawabata, “Electron microscopy of the rat hypothalamic neurosecretory system. II. Nucleolus-like inclusion bodies in the cytoplasm of neurosecretory cells,” Arch. Histol. Jpn., 26, No. 2, 101–113 (1965).
P. Panula and S. Nuutinen, “Histamine and H3 receptor in alcohol- related behaviors,” J. Pharmacol. Exp., 336, No. 1, 9–16 (2011).
G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, London (2007).
S. M. Zimatkin and K. O. Lindros, “Distribution of catalase in rat brain: aminergic neurons as possible targets for ethanol effects,” Alcohol Alcohol., 31, 167–174 (1996).
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Translated from Morfologiya, Vol. 146, No. 5, pp. 19–23, September–October, 2014.
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Zimatkin, S.M., Fedina, E.M. Ultrastructural Changes in Cerebral Histaminergic Neurons on Exposure to Alcohol. Neurosci Behav Physi 45, 873–877 (2015). https://doi.org/10.1007/s11055-015-0158-9
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DOI: https://doi.org/10.1007/s11055-015-0158-9