Abstract
A novel bionanosensor (BNS) with multi-walled carbon nanotubes for the precise detection of DNA-hybridization was developed earlier using intermediate frequency electrical measurements. In the earlier project also a modeling technique for detailed understanding of the DNA-hybridization taking place on the surface of a sensor was also developed. In the current project, the authors have advanced the BNS fabrication using buckypaper for highly efficient detection of DNA-hybridization with controlled device resistance. Buckypaper is a thin sheet of an aggregate of carbon nanotubes (CNTs). Furthermore, the modeling of these sensors using pole-zero plots in the z-plane suggests the orientation of CNTs within the buckypaper in the presence of hybridized-DNA in the high frequency range (12–16 MHz). This modeling technique is not limited only to the BNS under study but significantly increases our knowledge on CNT–DNA interaction. Thus, this research yields successful application of buckypaper as a BNSs and strongly suggests the possible orientation of CNTs within buckypaper using hybridized-DNA at a high frequency range.
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Notes
Gain: “voltage gain” computed by taking a ratio of output voltage to the input voltage
Frequency generator: 20 MHz sine and square wave generation, 1 MHz ramp and triangular wave generation and 14 bit resolution with 400 MS/s sample rate
Scope: 100 MHz bandwidth, 100 MS/s real time and 2.5 GS/s random interleaved sampling
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Acknowledgments
The authors wish to acknowledge University of New Haven for providing support and funding for this project.
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Desai, V., Aliane, B., Tsai, PJ. et al. Frequency analysis and application of a buckypaper-based bionanosensor. J Nanopart Res 15, 1503 (2013). https://doi.org/10.1007/s11051-013-1503-y
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DOI: https://doi.org/10.1007/s11051-013-1503-y